There seems to be another full #AI paper, this time published by #MDPI:
www.mdpi.com/1422-0067/26...

Have you not heard of the famous "Amybid Plakes" in #Alzheimers? Also, why does this paper list everything they write unter Methods? And why are there EM dahes in the abstract?

Nice start to the 3. #Channelopathies meeting in #Tübingen yesterday. #epilepsy #DEE #autism Join online at ec.europa.eu/eusurvey/run...

Nice paper by Keith et al. on the importance of the perirhinal area for spatial learning in mouse models of autism.
doi.org/10.1126/scia...

I wonder though why they did the viral knockdown of Scn2a so late (P20). Here, Scn2a is getting replaced by Scn8a in most AIS already:
doi.org/10.1093/brai...

Lovely conference is coming to an end. Our Tübingen delegation had a blast communicating about science and (re-)connecting with other scientists.
Thank you @neurowissg.bsky.social !

And third, some analyses are just strange. Why would you calculate #pseudotime for a population of cells that are from clearly different lineages, like neurons and microglia? Why would you calculate the change of Rack1 expression over pseudotime, but not split it by the conditions you looked at?

Second, some graphs in the figures themselves are mislabelled. Fig 1C has “epithelial cells” two times and “oligodendrocytes” are missing. Fig. 10A and Fig. 10B are clearly at odds with each other, depicting different magnitudes of current injections.
(2 of 4)

This amazing study reconstructed the exact composition of GABA-A receptors from #epilepsy patients using cryo EM:
doi.org/10.1038/s415...

There are some things in #epilepsy that are ever so counterintuitive. Here, blocking GABA rezeptors with gabazine decreases firing rates of pyramidal and inhibitory neurons only in mice with epilepsy due to a loss-of-function in #Scn1a.
Taken from this very nice paper: doi.org/10.1093/brai...