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Epilepsia Open

@epilepsia-open.bsky.social

This post hoc analysis evaluates perampanel as first adjunctive therapy for epilepsy across different clinical and regional settings.
doi.org/10.1002/epi4...

#epilepsy #ILAE #epilepsiaopen #antiseizuremedication #firstaddontherapy #focalepilepsy #focalonsetseizures #tonicclonicseizures #perampanel

November 20, 2025 at 5:18 PM

Epilepsia Open

@epilepsia-open.bsky.social

Epilepsy is associated with significantly increased long-term risk of cardiovascular disease.
doi.org/10.1002/epi4...

#epilepsy #ILAE #epilepsiaopen #cardiovasculardiseases #riskfactors #SouthKorea

November 19, 2025 at 7:04 PM

Epilepsia Open

@epilepsia-open.bsky.social

This is a pediatric case series of patients suffering from multifocal or generalized drug-resistant epilepsy treated with centromedian RNS.
doi.org/10.1002/epi4...

#epilepsy #ilae #epilepsiaopen #centromediannucleus #thalamus #drugresistantepilepsy #pediatric #responsiveneurostimulation

November 17, 2025 at 4:27 PM

Epilepsia Open

@epilepsia-open.bsky.social

We compared the early adjuvant treatment outcomes of IV lacosamide and levetiracetam for status epilepticus after benzodiazepine use.
doi.org/10.1002/epi4...

#epilepsy #ILAE #epilepsiaopen #antiseizuremedication #diagnosisprocedurecombination #overlapweighting #propensityscore #seizure

November 17, 2025 at 4:26 PM

Epilepsia Open

@epilepsia-open.bsky.social

Combined multimodal imaging (82–100% sensitivity) outperforms single modalities for localizing epileptogenic foci in surgical candidates.
doi.org/10.1002/epi4...

#epilepsy #ILAE #epilepsiaopen #multimodalimaging #neuroimaging #radiosurgery #stereotactic

November 13, 2025 at 6:51 PM

Epilepsia Open

@epilepsia-open.bsky.social

The study compared the effectiveness of 5 mg melatonin versus partial sleep deprivation in inducing sleep during nap-time EEG in children with epilepsy.
doi.org/10.1002/epi4...

#epilepsy #ILAE #epilepsiaopen #melatonin #napEEG #sleepinduction #sleeplatency

November 12, 2025 at 4:08 PM

Epilepsia Open

@epilepsia-open.bsky.social

This review provides a practical approach to assessing and selecting PROMs, and discusses how they may be incorporated into clinic workflows.
doi.org/10.1002/epi4...

#epilepsy #ILAE #epilepsiaopen #mooddisorders #patientreportedoutcome #qualityoflife #seizure

November 11, 2025 at 3:46 PM

Epilepsia Open

@epilepsia-open.bsky.social

New in Epilepsia Open – November 9, 2025
mailchi.mp/ilae/epileps...

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#epilepsy #epilepsiaopen #ILAE #EpilepsyResearch #NewInEpilepsy #JustPublished #LatestResearch

November 10, 2025 at 3:51 PM

Epilepsia Open

@epilepsia-open.bsky.social

Global adolescent epilepsy burden increased 1990–2021, with marked regional and SDI disparities.
doi.org/10.1002/epi4...

#epilepsy #ILAE #epilepsiaopen #adolescenthealth #globalburdenofdisease #healthpolicy #publichealth

November 7, 2025 at 3:33 PM

Epilepsia Open

@epilepsia-open.bsky.social

Approximately, 26% patients with unexplained seizures or epilepsy deterioration tested positive for autoimmune or paraneoplastic antibodies.
doi.org/10.1002/epi4...

#epilepsy #ILAE #epilepsiaopen #antibodytesting #APEscore #autoimmuneencephalitis #EEG #paraneoplasticencephalitis

November 7, 2025 at 3:32 PM

Epilepsia Open

@epilepsia-open.bsky.social

After a median follow-up of 20 months, CBD was globally effective and safe in 107 patients with LGS, DS, TSC, and other DEEs.
doi.org/10.1002/epi4...

#epilepsy #ILAE #epilepsiaopen #CBD #DEE #Dravetsyndrome #LennoxGastautsyndrome #realworld #cannabidiol

November 6, 2025 at 5:05 PM

Epilepsia Open

@epilepsia-open.bsky.social

This MR study assessed causal links between thousands of plasma proteins and epilepsy risk.
doi.org/10.1002/epi4...

#epilepsy #ILAE #epilepsiaopen #causalinference #GWAS #MR #plasmaproteins

November 5, 2025 at 2:56 PM

Epilepsia Open

@epilepsia-open.bsky.social

The preponderance of evidence indicates that the KD is effective in targeting IESS.
doi.org/10.1002/epi4...

#epilepsy #ILAE #epilepsiaopen #acidosis #infantileepilepticspasms #ketogenicdiet #microbiome #tryptophan

November 4, 2025 at 5:50 PM

Epilepsia Open

@epilepsia-open.bsky.social

Serum phosphate measurements are rarely included in the acute evaluation of Transient Loss of Consciousness (TLoC).
doi.org/10.1002/epi4...

#epilepsy #ILAE #epilepsiaopen #biomarker #electrolyte #hypophosphatemia #seizure #telemedicine

November 3, 2025 at 7:32 PM

Epilepsia Open

@epilepsia-open.bsky.social

Letter and Response - Addressing "SCN1A gain of function effects in Dravet syndrome: Insights into clinical phenotypes and therapeutic implications"

Letter: doi.org/10.1002/epi4...
Authors’ Response: doi.org/10.1002/epi4...
Original Article: doi.org/10.1002/epi4...

#Epilepsiaopen #Epilepsy #ILAE

To the editors: SCN1A gain‐of‐function effects in Dravet syndrome: Insights into clinical phenotypes and therapeutic implications

Click on the article title to read more.

doi.org

October 28, 2025 at 5:45 PM

Epilepsia Open

@epilepsia-open.bsky.social

New in Epilepsia Open – October 26, 2025
mailchi.mp/ilae/epileps...

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#epilepsy #epilepsiaopen #ILAE #EpilepsyResearch #NewInEpilepsy #JustPublished #LatestResearch

October 27, 2025 at 7:37 PM

Epilepsia Open

@epilepsia-open.bsky.social

The degree and frequency of language decline reported in research literature are influenced by the protocols used to assess language functions.
doi.org/10.1002/epi4...

#epilepsy #ILAE #epilepsiaopen #confrontationnaming #languageoutcomes #reliablechange #temporallobeepilepsy #verbalfluency

October 27, 2025 at 7:36 PM

Epilepsia Open

@epilepsia-open.bsky.social

69.8% of epilepsy patients preferred in-person care despite high digital literacy and environmental concern.
doi.org/10.1002/epi4...

#epilepsy #ilae #epilepsiaopen #climatechange #telemedicine #digitalliteracy #enviromentalawareness

October 23, 2025 at 2:28 PM

Epilepsia Open

@epilepsia-open.bsky.social

Progressive clonic slowing is associated with marked oxygen desaturation during bilateral tonic–clonic seizures.
doi.org/10.1002/epi4...

#epilepsy #ilae #epilepsiaopen #SUDEP #Progressiveclonicslowing #PostictalImmobility #Tonicclonicseizure #Respiratorydysfunction

October 22, 2025 at 7:22 PM

Epilepsia Open

@epilepsia-open.bsky.social

The multiple-hit rat model is a model of structural etiology drug-resistant infantile epileptic spasms syndrome (IESS).
doi.org/10.1002/epi4...

#epilepsy #ilae #epilepsiaopen #Sivelestat #fingolimod #methylprednisolone #topiramate #insulingrowthfactor

October 21, 2025 at 4:32 PM

Epilepsia Open

@epilepsia-open.bsky.social

To target seizure freedom, physicians should aim to optimize treatment, minimize delays, and improve medication adherence.
doi.org/10.1002/epi4...

#epilepsy #epilepsiaopen #ILAE #antiseizuremedications #inflammation #qualityoflife #seizure

October 20, 2025 at 6:20 PM

Epilepsia Open

@epilepsia-open.bsky.social

Although most became eligible to drive after VNS implantation without significant medication changes, some required additional medication changes to achieve seizure control.
doi.org/10.1002/epi4...

#epilepsy #epilepsiaopen #ILAE #driving #drugresistantepilepsy #vagusnervestimulation #VNS