Epithelial Cell Biology in ENT Research Group UCL
@epicentr.bsky.social
🔬Stem cell biology and cancer research team at the UCL Institute of Child Health
🥼Led by @robhynds.bsky.social and Colin Butler
📍Great Ormond Street Hospital and University College London
🥼Led by @robhynds.bsky.social and Colin Butler
📍Great Ormond Street Hospital and University College London
Lizzie Maughan @uclchildhealth.bsky.social led this collaboration with Wenhui Song's lab to develop a bespoke airway stent for use in a 5-month-old with near-complete laryngeal stenosis. The novel 3D-printed stent enabled safe airway reconstruction.
📄 doi.org/10.1002/adfm...
📄 doi.org/10.1002/adfm...
A Bespoke Programmable Interpenetrating Elastomer Network Composite Laryngeal Stent for Expedited Paediatric Laryngotracheal Reconstruction
A programmable interpenetrating double-network architecture, created via 3D-TIPS printing and resin infusion, synergistically combines thermoplastic and thermosetting elastomers to balance structural....
doi.org
November 11, 2025 at 11:56 AM
Lizzie Maughan @uclchildhealth.bsky.social led this collaboration with Wenhui Song's lab to develop a bespoke airway stent for use in a 5-month-old with near-complete laryngeal stenosis. The novel 3D-printed stent enabled safe airway reconstruction.
📄 doi.org/10.1002/adfm...
📄 doi.org/10.1002/adfm...
Our latest work is available on BioRxiv!
WS6 allows extended culture of basal epithelial cells and allows clonal expansion of primary airway epithelial cells after CRISPR editing, with clonal populations retaining their differentiation capacity.
www.biorxiv.org/content/10.1...
WS6 allows extended culture of basal epithelial cells and allows clonal expansion of primary airway epithelial cells after CRISPR editing, with clonal populations retaining their differentiation capacity.
www.biorxiv.org/content/10.1...
WS6 enables scalable ex vivo expansion and gene editing of epithelial basal stem cells
Modeling human epithelial diseases and developing cell-based therapies require robust methods to expand and manipulate epithelial stem and progenitor cells in vitro. Basal stem/progenitor cells from s...
www.biorxiv.org
September 16, 2025 at 7:24 PM
Our latest work is available on BioRxiv!
WS6 allows extended culture of basal epithelial cells and allows clonal expansion of primary airway epithelial cells after CRISPR editing, with clonal populations retaining their differentiation capacity.
www.biorxiv.org/content/10.1...
WS6 allows extended culture of basal epithelial cells and allows clonal expansion of primary airway epithelial cells after CRISPR editing, with clonal populations retaining their differentiation capacity.
www.biorxiv.org/content/10.1...
Reposted by Epithelial Cell Biology in ENT Research Group UCL
Had a wonderful time at the @bsgct.bsky.social annual conference!
I was delighted to be able to share our work on human airway epithelial cell culture for transplantation and how this contributes to the @epicentr.bsky.social efforts towards a cell and gene therapy for airway epidermolysis bullosa.
I was delighted to be able to share our work on human airway epithelial cell culture for transplantation and how this contributes to the @epicentr.bsky.social efforts towards a cell and gene therapy for airway epidermolysis bullosa.
June 24, 2025 at 9:02 AM
Had a wonderful time at the @bsgct.bsky.social annual conference!
I was delighted to be able to share our work on human airway epithelial cell culture for transplantation and how this contributes to the @epicentr.bsky.social efforts towards a cell and gene therapy for airway epidermolysis bullosa.
I was delighted to be able to share our work on human airway epithelial cell culture for transplantation and how this contributes to the @epicentr.bsky.social efforts towards a cell and gene therapy for airway epidermolysis bullosa.
Reposted by Epithelial Cell Biology in ENT Research Group UCL
Yuki Ishii, @jess0rr.bsky.social Sam Janes, @robhynds.bsky.social @epicentr.bsky.social & team identify Wnt pathway activators as potential pro-regenerative therapies in their compound screen in human airway basal cells.
journals.biologists.com/jcs/article/...
journals.biologists.com/jcs/article/...
journals.biologists.com/jcs/article/...
journals.biologists.com/jcs/article/...
April 17, 2025 at 12:52 PM
Yuki Ishii, @jess0rr.bsky.social Sam Janes, @robhynds.bsky.social @epicentr.bsky.social & team identify Wnt pathway activators as potential pro-regenerative therapies in their compound screen in human airway basal cells.
journals.biologists.com/jcs/article/...
journals.biologists.com/jcs/article/...
journals.biologists.com/jcs/article/...
journals.biologists.com/jcs/article/...
🚨Today our phenotypic screening work with primary human airway basal cells is published @jcellsci.bsky.social!
We found that multiple Wnt activating compounds promote basal cell proliferation and validated 1-azakenpaullone in vivo.
doi.org/10.1242/jcs....
We found that multiple Wnt activating compounds promote basal cell proliferation and validated 1-azakenpaullone in vivo.
doi.org/10.1242/jcs....
Compound screening in human airway basal cells identifies Wnt pathway activators as potential pro-regenerative therapies
Summary: A high-throughput screen of 1429 compounds in primary human airway epithelial cells was used to identify that Wnt pathway-activating compounds increase cell proliferation.
doi.org
April 14, 2025 at 10:28 AM
🚨Today our phenotypic screening work with primary human airway basal cells is published @jcellsci.bsky.social!
We found that multiple Wnt activating compounds promote basal cell proliferation and validated 1-azakenpaullone in vivo.
doi.org/10.1242/jcs....
We found that multiple Wnt activating compounds promote basal cell proliferation and validated 1-azakenpaullone in vivo.
doi.org/10.1242/jcs....
Happy holidays from everyone in the EpiCENTR group!
Follow @jess0rr.bsky.social and @drewfarr.bsky.social for our latest throughout 2025 🎁
(h/t scholargoggler.com)
Follow @jess0rr.bsky.social and @drewfarr.bsky.social for our latest throughout 2025 🎁
(h/t scholargoggler.com)
December 23, 2024 at 7:10 PM
Happy holidays from everyone in the EpiCENTR group!
Follow @jess0rr.bsky.social and @drewfarr.bsky.social for our latest throughout 2025 🎁
(h/t scholargoggler.com)
Follow @jess0rr.bsky.social and @drewfarr.bsky.social for our latest throughout 2025 🎁
(h/t scholargoggler.com)
Reposted by Epithelial Cell Biology in ENT Research Group UCL
Here's a starter pack that focusses on lung biology, regeneration and cancer.
Let me know who I'm missing!
go.bsky.app/VC83FZm
Let me know who I'm missing!
go.bsky.app/VC83FZm
November 17, 2024 at 4:40 PM
Here's a starter pack that focusses on lung biology, regeneration and cancer.
Let me know who I'm missing!
go.bsky.app/VC83FZm
Let me know who I'm missing!
go.bsky.app/VC83FZm