Six validation gaps analyzed: medium.com/@enginyapici...
#AntibodyDesign #DrugDiscovery #ProteinEngineering #AI
Six validation gaps analyzed: medium.com/@enginyapici...
#AntibodyDesign #DrugDiscovery #ProteinEngineering #AI
*reads 31-page Chai Discovery paper*
Okay, 88 functional mAbs with atomic accuracy is legit. But success is template-dependent and varies 4-100% by target.
Full analysis: medium.com/@enginyapici...
#AntibodyDesign #DrugDiscovery #ProteinEngineering
*reads 31-page Chai Discovery paper*
Okay, 88 functional mAbs with atomic accuracy is legit. But success is template-dependent and varies 4-100% by target.
Full analysis: medium.com/@enginyapici...
#AntibodyDesign #DrugDiscovery #ProteinEngineering
medium.com/@enginyapici...
medium.com/@enginyapici...
medium.com/@enginyapici...
Recursion and Valence outline a big vision for modeling biology. This post adds what I think are still-missing layers: metabolite-driven regulation, protein-level function, and failure-based learning.
#Biotech #AIHealthcare
medium.com/@enginyapici...
Recursion and Valence outline a big vision for modeling biology. This post adds what I think are still-missing layers: metabolite-driven regulation, protein-level function, and failure-based learning.
#Biotech #AIHealthcare
Naturally paired, functionally diverse, and validated early (blockers, agonists, bins).
medium.com/@enginyapici...
#AntibodyDiscovery #DrugDiscovery #Microfluidics #Biotech
Naturally paired, functionally diverse, and validated early (blockers, agonists, bins).
medium.com/@enginyapici...
#AntibodyDiscovery #DrugDiscovery #Microfluidics #Biotech
No iterative wet-lab cycles. No massive screens.
They solve three big problems in one shot: escape recovery, developability, diversity.
I broke it down here:
medium.com/@enginyapici...
#AntibodyEngieering #Biotech #AntibodyDiscovery #AI
No iterative wet-lab cycles. No massive screens.
They solve three big problems in one shot: escape recovery, developability, diversity.
I broke it down here:
medium.com/@enginyapici...
#AntibodyEngieering #Biotech #AntibodyDiscovery #AI
Entabolons = proteins functionally linked by the same metabolite. No interaction, no pathway step: just a shared dependency missing from most models.
medium.com/@enginyapici...
#drugdiscovery #systemsbiology
Entabolons = proteins functionally linked by the same metabolite. No interaction, no pathway step: just a shared dependency missing from most models.
medium.com/@enginyapici...
#drugdiscovery #systemsbiology
Here’s my take on how this could backfire for biotech teams or become an edge for first-time filers: medium.com/@enginyapici...
#biotech #fda #ai
Here’s my take on how this could backfire for biotech teams or become an edge for first-time filers: medium.com/@enginyapici...
#biotech #fda #ai
Ginkgo’s PROPHET-Ab platform runs real assays, at scale, upstream, and cleanly. But can it handle messy, early-stage variants?
medium.com/@enginyapici...
#DrugDevelopment #AIinBiotech #Antibodies #DrugDiscovery #Biologics #AI
Ginkgo’s PROPHET-Ab platform runs real assays, at scale, upstream, and cleanly. But can it handle messy, early-stage variants?
medium.com/@enginyapici...
#DrugDevelopment #AIinBiotech #Antibodies #DrugDiscovery #Biologics #AI
It measures how long a single molecule stays trapped, and turns that into size, shape, and binding data. No freezing, no tethering, no guessing.
medium.com/@enginyapici...
#Biotech #DrugDiscovery #ProteinStructure #StructuralBiology
It measures how long a single molecule stays trapped, and turns that into size, shape, and binding data. No freezing, no tethering, no guessing.
medium.com/@enginyapici...
#Biotech #DrugDiscovery #ProteinStructure #StructuralBiology
I walk through what’s often missing: scaffold diversity, expression, off-target data, developability. And why these matter if we want the models to translate.
medium.com/@enginyapici...
I walk through what’s often missing: scaffold diversity, expression, off-target data, developability. And why these matter if we want the models to translate.
medium.com/@enginyapici...
I wrote about a new benchmark that puts autonomous systems to the test: no handholding, no domain hints.
Where they shine, where they fail, and what it means for drug discovery.
medium.com/@enginyapici...
#DrugDiscovery #AIDrugDiscovery
I wrote about a new benchmark that puts autonomous systems to the test: no handholding, no domain hints.
Where they shine, where they fail, and what it means for drug discovery.
medium.com/@enginyapici...
#DrugDiscovery #AIDrugDiscovery
Building Better Antibodies: Lessons from SynAbLib and IgHuAb
How large language models are helping design human-like antibody libraries that are actually usable for discovery.
medium.com/@enginyapici...
#AntibodyDiscovery #Biotechnology #MachineLearning #DrugDiscovery
Building Better Antibodies: Lessons from SynAbLib and IgHuAb
How large language models are helping design human-like antibody libraries that are actually usable for discovery.
medium.com/@enginyapici...
#AntibodyDiscovery #Biotechnology #MachineLearning #DrugDiscovery
www.linkedin.com/pulse/ai-dru...
#GenerativeAI #DrugDiscovery #AIDrugDiscovery #AI #ML
www.linkedin.com/pulse/ai-dru...
#GenerativeAI #DrugDiscovery #AIDrugDiscovery #AI #ML
DeepViscosity uses antibody sequence alone to flag formulation risks, before any wet-lab work. I break down what the model does well, where it fits in real workflows, and how it compares to other tools.
medium.com/@enginyapici...
#biologics
DeepViscosity uses antibody sequence alone to flag formulation risks, before any wet-lab work. I break down what the model does well, where it fits in real workflows, and how it compares to other tools.
medium.com/@enginyapici...
#biologics
I wrote about PG-AbD, a solid framework with no wet-lab validation, and why that's not a dead end, just a missed opportunity.
medium.com/@enginyapici...
#AI #DrugDiscovery #AntibodyDiscovery #AIinBiotech #Biotech #GenerativeAI
I wrote about PG-AbD, a solid framework with no wet-lab validation, and why that's not a dead end, just a missed opportunity.
medium.com/@enginyapici...
#AI #DrugDiscovery #AntibodyDiscovery #AIinBiotech #Biotech #GenerativeAI
Most models are trained on actives, but real signal might lie in the compounds that quietly fail. I wrote about InertDB, a dataset of verified negatives, and what it means for model reliability.
tinyurl.com/InertDB-Medium
#DrugDiscovery #AI
Most models are trained on actives, but real signal might lie in the compounds that quietly fail. I wrote about InertDB, a dataset of verified negatives, and what it means for model reliability.
tinyurl.com/InertDB-Medium
#DrugDiscovery #AI
Valentina Matos-Romero, Ashley Kiemen and team have put together an ultra detailed protocol to use CODA for 3D single-cell mapping of tissues, organs, and organisms.
Use CODA by downloading this protocol here: www.biorxiv.org/content/10.1...
Valentina Matos-Romero, Ashley Kiemen and team have put together an ultra detailed protocol to use CODA for 3D single-cell mapping of tissues, organs, and organisms.
Use CODA by downloading this protocol here: www.biorxiv.org/content/10.1...
We attempt to integrate the data on CD8 T cell dysfunction into a new framework of hypofunctionality in cancer and chronic infections!
www.nature.com/articles/s41...
We attempt to integrate the data on CD8 T cell dysfunction into a new framework of hypofunctionality in cancer and chronic infections!
www.nature.com/articles/s41...
medium.com/@enginyapici...
#SingleCell #AntibodyDiscovery #ScreeningTech #FunctionalAssays #Biotech
medium.com/@enginyapici...
#SingleCell #AntibodyDiscovery #ScreeningTech #FunctionalAssays #Biotech
Intro: medium.com/@enginyapici...
#DrugDiscovery #AntibodyEngineering #Bioassays #MoA #Biotech
Intro: medium.com/@enginyapici...
#DrugDiscovery #AntibodyEngineering #Bioassays #MoA #Biotech