Johnathon Emlaw
emlawjohnathon.bsky.social
Johnathon Emlaw
@emlawjohnathon.bsky.social
Postdoc @ The Rockefeller University | formerly University of Ottawa | Structure and function of ion channels.
Reposted by Johnathon Emlaw
Petition to Reverse the NIH Indirect Cost Cap initiated by Tom Maniatis. Please amplify
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Petition to Reverse the NIH Indirect Cost Cap (NOT-OD-25-068)
chng.it
February 10, 2025 at 5:49 PM
Reposted by Johnathon Emlaw
So happy to finally share my final paper from my PhD! By collecting cryo-EM datasets at sub-saturating concentrations of ACh, we were able to determine a mono-liganded state of the muscle-type nAChR. This state has a fully activated alpha subunit where ACh binds…

www.biorxiv.org/content/10.1...
Asynchronous subunit transitions precede acetylcholine receptor activation
Rapid communication at synapses is facilitated by postsynaptic receptors, which convert a chemical signal into an electrical response. In the case of ligand-gated ion channels, agonist binding trigger...
www.biorxiv.org
December 3, 2024 at 4:39 PM