Emily Goetzler
@emily-goetzler.bsky.social
PhD Candidate at Weill Cornell Medicine studying epigenetic regulation in early development.
Reposted by Emily Goetzler
Excited to share our new study in @cp-devcell.bsky.social dissecting how the brain-associated transcription factor OTX2 drives anteriorization of the mammalian gut by enhancer remodeling using stem cell-based models. #development #enhancers #patterning #stemcells
www.cell.com/developmenta...
www.cell.com/developmenta...
Enhancer remodeling by OTX2 directs specification and patterning of mammalian definitive endoderm
Correct patterning of emerging tissues in the developing embryo is essential for the
formation of functional organ systems. Using genetic tools for controlled protein
depletion, Ee et al. identify the...
www.cell.com
August 19, 2025 at 6:14 PM
Excited to share our new study in @cp-devcell.bsky.social dissecting how the brain-associated transcription factor OTX2 drives anteriorization of the mammalian gut by enhancer remodeling using stem cell-based models. #development #enhancers #patterning #stemcells
www.cell.com/developmenta...
www.cell.com/developmenta...
Reposted by Emily Goetzler
Led by Ly-sha Ee and @danielmedinacano.bsky.social, with thanks to our collaborators @tvierbuchen.bsky.social, Alex Polyzos, @efapostolou29.bsky.social and Kat Hanjantonakis.
August 19, 2025 at 6:14 PM
Led by Ly-sha Ee and @danielmedinacano.bsky.social, with thanks to our collaborators @tvierbuchen.bsky.social, Alex Polyzos, @efapostolou29.bsky.social and Kat Hanjantonakis.
Reposted by Emily Goetzler
Our work on the regulation is out www.cell.com/stem-cell-re...! Congrats to our collaborators in the Vierbuchen and Mezey labs. It turns out that genetic variation has to be very much considered if you want to harness stem cells safely in biomedicine. #pluripotency #epigenetics #stemcells
Genetic variation modulates susceptibility to aberrant DNA hypomethylation and imprint deregulation in naive pluripotent stem cells
Pluripotent stem cells are susceptible to acquiring detrimental epigenetic abnormalities,
posing a hurdle to their safe use in biomedical applications. Using pluripotent cells
with defined genetic bac...
www.cell.com
March 13, 2025 at 8:41 PM
Our work on the regulation is out www.cell.com/stem-cell-re...! Congrats to our collaborators in the Vierbuchen and Mezey labs. It turns out that genetic variation has to be very much considered if you want to harness stem cells safely in biomedicine. #pluripotency #epigenetics #stemcells