https://orcid.org/0000-0002-1754-5336
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Myeloma / Plasma Cell Dyscrasia ~ #ASH24Top10 (or so) #mmsm #mmMRD #ASH24 - @mtmdphd *DRAFT* Table Update: Dec 1, 2024 - cc @grpetersen1 - @bdermanmd @bhemato @End_myeloma @HadidiSamer @jmikhaelmd @ManniMD1 @MeeraMohanMD @MyelomaTeacher @RahulBanerjeeMD @rajshekharucms @szusmani @VincentRK
Myeloma / Plasma Cell Dyscrasia ~ #ASH24Top10 (or so) #mmsm #mmMRD #ASH24 - @mtmdphd *DRAFT* Table Update: Dec 1, 2024 - cc @grpetersen1 - @bdermanmd @bhemato @End_myeloma @HadidiSamer @jmikhaelmd @ManniMD1 @MeeraMohanMD @MyelomaTeacher @RahulBanerjeeMD @rajshekharucms @szusmani @VincentRK
Talquetamab Bridging before CAR-T
-Talq bridging: 62% ORR (14% CR)
-Post-CAR-T: 97.5% ORR (35% CR)
-Safety: Mild toxicities during talq (no grade ≥3 CRS, 2.5% ICANS)
-Post-CAR-T: less CRS (65%), ICANS (2% grade 3)
Should be standard of care #mmsm @ash-hematology.bsky.social
Talquetamab Bridging before CAR-T
-Talq bridging: 62% ORR (14% CR)
-Post-CAR-T: 97.5% ORR (35% CR)
-Safety: Mild toxicities during talq (no grade ≥3 CRS, 2.5% ICANS)
-Post-CAR-T: less CRS (65%), ICANS (2% grade 3)
Should be standard of care #mmsm @ash-hematology.bsky.social
medicinraadet.dk/anbefalinger...
medicinraadet.dk/anbefalinger...
1. Never just order immunofix. Plz get SPEP (neuro, I’m looking at you)
2. If radiologist calls MRI: weird-looking marrow “might be myeloma”, plz ✔️CBC/SPEP/immunofix-or-immunotyping.
3. CKD w/ ⬆️ light chains, nl ratio? Don’t call me plz.
Chapter 1
1. Order a peripheral smear before they ask
2. Never get a CBC without a diff
3. Stop the heparin before you call for a HIT consult
4. NEVER order MTHFR
5. Order a reticulocyte count before you consult for anemia
1. Never just order immunofix. Plz get SPEP (neuro, I’m looking at you)
2. If radiologist calls MRI: weird-looking marrow “might be myeloma”, plz ✔️CBC/SPEP/immunofix-or-immunotyping.
3. CKD w/ ⬆️ light chains, nl ratio? Don’t call me plz.
pca.st/episode/beee...
pca.st/episode/beee...
For simplicity, I excluded investigational drugs and focused on:
1️⃣ #MMsm response assessments
2️⃣ Optimizing bsAbs
3️⃣ (Soon) practice-changing
I’ve found it incredibly useful helpful to give the 10,000ft view at initial diagnosis.
#HemeSky #OncSky #mmsm
Source: www.mayoclinic.org/medical-prof...
I’ve found it incredibly useful helpful to give the 10,000ft view at initial diagnosis.
#HemeSky #OncSky #mmsm
Source: www.mayoclinic.org/medical-prof...