Miki Ebisuya
@ebisuyamiki.bsky.social
Synthetic developmental biologist at PoL TU Dresden. Cross-species comparison and manipulation of the ORGANOID ZOO.
https://physics-of-life.tu-dresden.de/team/pol-groups/ebisuya
https://physics-of-life.tu-dresden.de/team/pol-groups/ebisuya
Overall, our findings identify basal fluidity a novel mechanical hallmark of early human forebrain development, which may contribute to the tangential surface expansion unique to humans.
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October 8, 2025 at 1:05 PM
Overall, our findings identify basal fluidity a novel mechanical hallmark of early human forebrain development, which may contribute to the tangential surface expansion unique to humans.
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Consistent with droplet motility, cell rearrangements occur more frequently in the basal region of human neuroepithelia, confirming basal fluidity. Such active rearrangements likely help accommodate newly divided nuclei migrating from the apical side.
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October 8, 2025 at 1:05 PM
Consistent with droplet motility, cell rearrangements occur more frequently in the basal region of human neuroepithelia, confirming basal fluidity. Such active rearrangements likely help accommodate newly divided nuclei migrating from the apical side.
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Inhibiting nuclear movement fluctuations through cell cycle inhibitors or N-cadherin overexpression suppresses basal fluidity in human neuroepithelia.
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October 8, 2025 at 1:05 PM
Inhibiting nuclear movement fluctuations through cell cycle inhibitors or N-cadherin overexpression suppresses basal fluidity in human neuroepithelia.
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We also found that human neuroepithelia have a lot of intercellular spaces in the basal region, constituting a permissive environment for basal fluidity.
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October 8, 2025 at 1:05 PM
We also found that human neuroepithelia have a lot of intercellular spaces in the basal region, constituting a permissive environment for basal fluidity.
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We found that basal fluidity is driven by greater fluctuations in nuclear movement within the basal region of human neuroepithelia.
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October 8, 2025 at 1:05 PM
We found that basal fluidity is driven by greater fluctuations in nuclear movement within the basal region of human neuroepithelia.
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Although human, gorilla, and mouse neuroepithelia appear similar, oil microdroplets move dynamically only in the basal region of human neuroepithelia. This droplet motility ceases as neurogenesis began.
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October 8, 2025 at 1:05 PM
Although human, gorilla, and mouse neuroepithelia appear similar, oil microdroplets move dynamically only in the basal region of human neuroepithelia. This droplet motility ceases as neurogenesis began.
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This work showcases Shuting @shutingxu.bsky.social’s creativity and dedication & a wonderful collaboration w/ Otger @campaslab.bsky.social who kept pushing interdiscipline boundaries!
Grateful for supportive environemnts at PoL@poldresden.bsky.social, EMBLBarcelona@embl.org, MPI-CBG@mpi-cbg.de 2/
Grateful for supportive environemnts at PoL@poldresden.bsky.social, EMBLBarcelona@embl.org, MPI-CBG@mpi-cbg.de 2/
October 8, 2025 at 1:05 PM
This work showcases Shuting @shutingxu.bsky.social’s creativity and dedication & a wonderful collaboration w/ Otger @campaslab.bsky.social who kept pushing interdiscipline boundaries!
Grateful for supportive environemnts at PoL@poldresden.bsky.social, EMBLBarcelona@embl.org, MPI-CBG@mpi-cbg.de 2/
Grateful for supportive environemnts at PoL@poldresden.bsky.social, EMBLBarcelona@embl.org, MPI-CBG@mpi-cbg.de 2/
New preprint from the lab! We discovered a transient fluidization in the basal region of human forebrains by tracking microdroplets in cerebral organoids.This “basal fluidization”, absent in gorilla and mouse, may contribute to greater surface expansion in human forebrains
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doi.org/10.1101/2025...
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doi.org/10.1101/2025...
October 8, 2025 at 1:05 PM
New preprint from the lab! We discovered a transient fluidization in the basal region of human forebrains by tracking microdroplets in cerebral organoids.This “basal fluidization”, absent in gorilla and mouse, may contribute to greater surface expansion in human forebrains
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doi.org/10.1101/2025...
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doi.org/10.1101/2025...
Today marks the end of my summer project! It was exciting to head to the lab each morning, thinking about my experiments and data. I hope to share some interesting results in the future. This annual ritual also reminds me as a PI: most experiments don’t go as planned👩🔬
August 30, 2025 at 12:59 PM
Today marks the end of my summer project! It was exciting to head to the lab each morning, thinking about my experiments and data. I hope to share some interesting results in the future. This annual ritual also reminds me as a PI: most experiments don’t go as planned👩🔬
Wonderful joint retreat with Yang lab @poldresden.bsky.social!
Renewed my enthusiasm for clarifying the energy budgets of diverse cells and organisms.
Grateful to the organizers for putting together such a fun and creative event!
Renewed my enthusiasm for clarifying the energy budgets of diverse cells and organisms.
Grateful to the organizers for putting together such a fun and creative event!
August 23, 2025 at 8:20 AM
Wonderful joint retreat with Yang lab @poldresden.bsky.social!
Renewed my enthusiasm for clarifying the energy budgets of diverse cells and organisms.
Grateful to the organizers for putting together such a fun and creative event!
Renewed my enthusiasm for clarifying the energy budgets of diverse cells and organisms.
Grateful to the organizers for putting together such a fun and creative event!
And here’s a Ghibli-style sneak peek of Shuting’s exciting project. We'll post a preprint soon! 2/2
June 17, 2025 at 5:38 PM
And here’s a Ghibli-style sneak peek of Shuting’s exciting project. We'll post a preprint soon! 2/2
Congratulations to newly minted Dr. Shuting Xu 🎉㊗️
As Shuting is the first PhD graduate from our Dresden lab, I was probably more nervous than she was. But Shuting delivered an outstanding, stimulating presentation and handled the Q&A with confidence. Very well done! 1/2
As Shuting is the first PhD graduate from our Dresden lab, I was probably more nervous than she was. But Shuting delivered an outstanding, stimulating presentation and handled the Q&A with confidence. Very well done! 1/2
June 17, 2025 at 5:38 PM
Congratulations to newly minted Dr. Shuting Xu 🎉㊗️
As Shuting is the first PhD graduate from our Dresden lab, I was probably more nervous than she was. But Shuting delivered an outstanding, stimulating presentation and handled the Q&A with confidence. Very well done! 1/2
As Shuting is the first PhD graduate from our Dresden lab, I was probably more nervous than she was. But Shuting delivered an outstanding, stimulating presentation and handled the Q&A with confidence. Very well done! 1/2
Our Physics of Life exhibition @poldresden.bsky.social is now open at the COSMO science forum.
Explore interactive materials in the beautiful glass building in the city center.
📍Schloßstraße 2, 01067 Dresden
Explore interactive materials in the beautiful glass building in the city center.
📍Schloßstraße 2, 01067 Dresden
April 8, 2025 at 7:38 PM
Our Physics of Life exhibition @poldresden.bsky.social is now open at the COSMO science forum.
Explore interactive materials in the beautiful glass building in the city center.
📍Schloßstraße 2, 01067 Dresden
Explore interactive materials in the beautiful glass building in the city center.
📍Schloßstraße 2, 01067 Dresden
While my lab made progress on the Stem Cell Zoo and Synthetic Dev Bio tools during the past 7 years, La Sagrada Família continued its own advancements
March 29, 2025 at 12:33 PM
While my lab made progress on the Stem Cell Zoo and Synthetic Dev Bio tools during the past 7 years, La Sagrada Família continued its own advancements
Closing our Barcelona lab is bittersweet. These seven years were amazing—thanks to EMBL Barcelona and the fantastic lab members/collaborators, I launched my dream projects of Synthetic Dev Bio and Stem Cell Zoo. Now, we’re taking them to PoL Dresden!
March 29, 2025 at 12:24 PM
Closing our Barcelona lab is bittersweet. These seven years were amazing—thanks to EMBL Barcelona and the fantastic lab members/collaborators, I launched my dream projects of Synthetic Dev Bio and Stem Cell Zoo. Now, we’re taking them to PoL Dresden!
For example, 2DG (a glycolysis inhibitor) slowed down protein production and degradation. Sodium azide (electron transport chain inhibitor) slowed down intron processing without affecting protein production or degradation. Oligomycin (ATP synthesis inhibitor) slowed down protein degradation only. 3/
January 24, 2025 at 6:41 PM
For example, 2DG (a glycolysis inhibitor) slowed down protein production and degradation. Sodium azide (electron transport chain inhibitor) slowed down intron processing without affecting protein production or degradation. Oligomycin (ATP synthesis inhibitor) slowed down protein degradation only. 3/
After an inspiring visit to MPI-EVA (thanks Genevieve Housman!), I’ve been re-reading one of my favorites, Neanderthal Man.
If you’re a young student considering PhD, read Chapter 2.
If you’re a PhD student feeling a bit lost in your project, read Chapter 2.
If you're...., read Chapter 2 anyway
If you’re a young student considering PhD, read Chapter 2.
If you’re a PhD student feeling a bit lost in your project, read Chapter 2.
If you're...., read Chapter 2 anyway
December 23, 2024 at 11:09 PM
After an inspiring visit to MPI-EVA (thanks Genevieve Housman!), I’ve been re-reading one of my favorites, Neanderthal Man.
If you’re a young student considering PhD, read Chapter 2.
If you’re a PhD student feeling a bit lost in your project, read Chapter 2.
If you're...., read Chapter 2 anyway
If you’re a young student considering PhD, read Chapter 2.
If you’re a PhD student feeling a bit lost in your project, read Chapter 2.
If you're...., read Chapter 2 anyway
We will have "Towards Redesigning Lifecycles" at RIKEN BDR, Kobe Japan, March 3-5!
Gorgeous Speakers🤓, Free Registration🤑, Japan in Spring🌸.
What else do you want?
The oral abstract deadline is Dec 15.
www2.bdr.riken.jp/sympo/2025/i...
Gorgeous Speakers🤓, Free Registration🤑, Japan in Spring🌸.
What else do you want?
The oral abstract deadline is Dec 15.
www2.bdr.riken.jp/sympo/2025/i...
November 26, 2024 at 6:05 PM
We will have "Towards Redesigning Lifecycles" at RIKEN BDR, Kobe Japan, March 3-5!
Gorgeous Speakers🤓, Free Registration🤑, Japan in Spring🌸.
What else do you want?
The oral abstract deadline is Dec 15.
www2.bdr.riken.jp/sympo/2025/i...
Gorgeous Speakers🤓, Free Registration🤑, Japan in Spring🌸.
What else do you want?
The oral abstract deadline is Dec 15.
www2.bdr.riken.jp/sympo/2025/i...
Although I often spotted woodpeckers in Dresden, I never actually caught them in action. Today I woke up to this sound!🐦
This little overachiever managed 20 pecks in just 4 sec and continued for at least 15 min. Inspired, I tried 5 clicks/sec with my finger and got completely exhausted after 1 min
This little overachiever managed 20 pecks in just 4 sec and continued for at least 15 min. Inspired, I tried 5 clicks/sec with my finger and got completely exhausted after 1 min
November 23, 2024 at 10:48 AM
Although I often spotted woodpeckers in Dresden, I never actually caught them in action. Today I woke up to this sound!🐦
This little overachiever managed 20 pecks in just 4 sec and continued for at least 15 min. Inspired, I tried 5 clicks/sec with my finger and got completely exhausted after 1 min
This little overachiever managed 20 pecks in just 4 sec and continued for at least 15 min. Inspired, I tried 5 clicks/sec with my finger and got completely exhausted after 1 min
Real Bluesky icon here🦋!
Seeing the structural coloring of blue morphos had been on my bucket list for a long time. Now ticked.
I want Apple to make a new shiny blue iPhone using the same principle
Seeing the structural coloring of blue morphos had been on my bucket list for a long time. Now ticked.
I want Apple to make a new shiny blue iPhone using the same principle
November 21, 2024 at 12:05 PM
Real Bluesky icon here🦋!
Seeing the structural coloring of blue morphos had been on my bucket list for a long time. Now ticked.
I want Apple to make a new shiny blue iPhone using the same principle
Seeing the structural coloring of blue morphos had been on my bucket list for a long time. Now ticked.
I want Apple to make a new shiny blue iPhone using the same principle
📢Register for the RIKEN BDR Symposium 2025 "Towards Redesigning Lifecycles," which will be held March 3-5, 2025 at
@BDR_RIKEN
Kobe Campus, Japan.
Participation fee: FREE (separate fees required for lunch/banquet- optional)
For details & deadlines👇
🔗https://www2.bdr.riken.jp/sympo/2025/
@BDR_RIKEN
Kobe Campus, Japan.
Participation fee: FREE (separate fees required for lunch/banquet- optional)
For details & deadlines👇
🔗https://www2.bdr.riken.jp/sympo/2025/
November 21, 2024 at 8:07 AM
📢Register for the RIKEN BDR Symposium 2025 "Towards Redesigning Lifecycles," which will be held March 3-5, 2025 at
@BDR_RIKEN
Kobe Campus, Japan.
Participation fee: FREE (separate fees required for lunch/banquet- optional)
For details & deadlines👇
🔗https://www2.bdr.riken.jp/sympo/2025/
@BDR_RIKEN
Kobe Campus, Japan.
Participation fee: FREE (separate fees required for lunch/banquet- optional)
For details & deadlines👇
🔗https://www2.bdr.riken.jp/sympo/2025/
Finally joined this platform! Looking forward to exploring fascinating science and research here again.
I'm interested in differences among animal species and how we can study them using stem cell-based models.
From tiny shrews (2 grams) to massive blue whales (150 tons), the diversity is astounding
I'm interested in differences among animal species and how we can study them using stem cell-based models.
From tiny shrews (2 grams) to massive blue whales (150 tons), the diversity is astounding
November 16, 2024 at 12:24 PM
Finally joined this platform! Looking forward to exploring fascinating science and research here again.
I'm interested in differences among animal species and how we can study them using stem cell-based models.
From tiny shrews (2 grams) to massive blue whales (150 tons), the diversity is astounding
I'm interested in differences among animal species and how we can study them using stem cell-based models.
From tiny shrews (2 grams) to massive blue whales (150 tons), the diversity is astounding