Ezequiel Galpern
@eag91.bsky.social
MSCA fellow at @crg.eu w/M. Dias and @jonnyfrazer.bsky.social
> Biological Physics | Proteins | Comp Bio | ML
https://scholar.google.com/citations?user=n55NtEsAAAAJ&hl=en
> Biological Physics | Proteins | Comp Bio | ML
https://scholar.google.com/citations?user=n55NtEsAAAAJ&hl=en
Our method for predicting folding dynamics/mechanisms from sequence info is now a book chapter! link.springer.com/book/9781071...
@diegulise.bsky.social
@diegulise.bsky.social
November 6, 2025 at 12:12 PM
Our method for predicting folding dynamics/mechanisms from sequence info is now a book chapter! link.springer.com/book/9781071...
@diegulise.bsky.social
@diegulise.bsky.social
Reposted by Ezequiel Galpern
Applications are open for the @crg_eu PhD Programme! 20 fully funded positions — including one in our group through the Evolutionary Medical Genomics ITN.
Join us to develop deep generative models of cross-species data to tackle open questions in disease genetics.
www.crg.eu/en/content/t...
Join us to develop deep generative models of cross-species data to tackle open questions in disease genetics.
www.crg.eu/en/content/t...
October 23, 2025 at 11:01 AM
Applications are open for the @crg_eu PhD Programme! 20 fully funded positions — including one in our group through the Evolutionary Medical Genomics ITN.
Join us to develop deep generative models of cross-species data to tackle open questions in disease genetics.
www.crg.eu/en/content/t...
Join us to develop deep generative models of cross-species data to tackle open questions in disease genetics.
www.crg.eu/en/content/t...
❗New Preprint w/ C Bueno (@cabb99.bsky.social), IE Sánchez (@nachoquique.bsky.social), PG Wolynes & DU Ferreiro (@diegulise.bsky.social)
We define the Protein Dark Energy and use it to localize and quantify the functional evolutionary constraints on natural proteins
arxiv.org/abs/2508.08109
We define the Protein Dark Energy and use it to localize and quantify the functional evolutionary constraints on natural proteins
arxiv.org/abs/2508.08109
Probing the Dark Energy in the Functional Protein Universe
We show how to localize and quantify the functional evolutionary constraints on natural proteins. The method compares the perturbations caused by local sequence variants to the energetics of the prote...
arxiv.org
August 12, 2025 at 2:49 PM
❗New Preprint w/ C Bueno (@cabb99.bsky.social), IE Sánchez (@nachoquique.bsky.social), PG Wolynes & DU Ferreiro (@diegulise.bsky.social)
We define the Protein Dark Energy and use it to localize and quantify the functional evolutionary constraints on natural proteins
arxiv.org/abs/2508.08109
We define the Protein Dark Energy and use it to localize and quantify the functional evolutionary constraints on natural proteins
arxiv.org/abs/2508.08109
Finally published!
“Inferring protein folding mechanisms from natural sequence diversity”
Open acces link: authors.elsevier.com/a/1lQvh1SPTB...
@biophysj.bsky.social
A new chapter of an amazing project w/ @diegulise.bsky.social and Ernesto Roman
1/n
“Inferring protein folding mechanisms from natural sequence diversity”
Open acces link: authors.elsevier.com/a/1lQvh1SPTB...
@biophysj.bsky.social
A new chapter of an amazing project w/ @diegulise.bsky.social and Ernesto Roman
1/n
authors.elsevier.com
July 15, 2025 at 8:57 PM
Finally published!
“Inferring protein folding mechanisms from natural sequence diversity”
Open acces link: authors.elsevier.com/a/1lQvh1SPTB...
@biophysj.bsky.social
A new chapter of an amazing project w/ @diegulise.bsky.social and Ernesto Roman
1/n
“Inferring protein folding mechanisms from natural sequence diversity”
Open acces link: authors.elsevier.com/a/1lQvh1SPTB...
@biophysj.bsky.social
A new chapter of an amazing project w/ @diegulise.bsky.social and Ernesto Roman
1/n
Reposted by Ezequiel Galpern
Investigadores que estudian el universo desde Argentina. Mi colaboración de hoy para Viva www.clarin.com/viva/detecti...
Los detectives espaciales que desde Argentina buscan entender el Universo
Se destacan en radioastronomía, astrobiología, física y geología planetaria. Quiénes son los científicos locales que buscan descifrar el Cosmos.
www.clarin.com
March 9, 2025 at 4:46 PM
Investigadores que estudian el universo desde Argentina. Mi colaboración de hoy para Viva www.clarin.com/viva/detecti...
Reposted by Ezequiel Galpern
En ciencia no hay preguntas pequeñas, pero igualmente divierte investigar con @diegulise.bsky.social y Ezequiel Galpern por qué hay 20 aminoácidos en las proteínas y 4 nucleótidos en el ARN doi.org/10.1590/SciE...
Why are there 20 amino acids and 4 nucleotides?
Evolution of folded biopolymers requires effective and fast search of both the conformational space for folding and the sequence space for evolution. Molecular information theory and energy landscape theory show that the alphabet size of extant proteins and RNA is just enough to fulfill these requirements, given the constraints posed by the chemical physics of these polymers. Empirical estimations of the size of the effective sequence and conformational spaces of natural biopolymers support the theoretical predictions.
doi.org
January 13, 2025 at 6:47 PM
En ciencia no hay preguntas pequeñas, pero igualmente divierte investigar con @diegulise.bsky.social y Ezequiel Galpern por qué hay 20 aminoácidos en las proteínas y 4 nucleótidos en el ARN doi.org/10.1590/SciE...