Sean Mullen, Ph.D.
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drseanmullen.bsky.social
Sean Mullen, Ph.D.
@drseanmullen.bsky.social
Research Director of the #Exercise #Technology & #Cognition Lab | #Movement #Neuroscience | Husband | Dad | #MartialArtist | #FlowArtist | #Tennis Teaching Pro | Advocate for Persons with Long Covid
Hey 👋

Cleaning the Pre-filters? Replacing filters?
November 7, 2025 at 2:52 AM
All three apply. You could add “immune damaging.”

Biohazard covers whether it was from a lab, bat or another origin. I’m sick of that argument.

Immune-mediated vasculopathy covers most of the damage. I add neuroinvasive because people forget that the 🧠 is an organ & the virus crosses the BBB.
November 6, 2025 at 2:28 AM
Which term is that?
November 6, 2025 at 2:20 AM
Nice!
November 6, 2025 at 1:32 AM
5. Absolute excess at 6 months: myocarditis/pericarditis 2.24 per 100k after infection vs 0.85 per 100k after vaccination.

Bottom line: infection carries rare-but-real, longer-lasting risks; vaccine risk is rarer, shorter, and smaller.
November 5, 2025 at 10:09 PM
4. After vaccination: only myocarditis/pericarditis rises short-term (wk-1 6.17×; wks 2–4 1.84×), no sustained signal beyond 4 wks.
November 5, 2025 at 10:09 PM
3. Some risks persist up to ≥12 months: VTE 1.39×, thrombocytopenia 1.42×, myocarditis/pericarditis 1.42× (vs no/before infection).
November 5, 2025 at 10:09 PM
2. After infection (week 1): ATE 2.33×, VTE 4.90×, thrombocytopenia 3.64×, myocarditis/pericarditis 3.46×, inflammatory syndromes 14.84×.
November 5, 2025 at 10:09 PM
And the former lodge at the North Rim that burned weeks after this photo.
November 1, 2025 at 6:28 PM
Cheers 🍻 to Tilley
November 1, 2025 at 6:27 PM
Me too.
November 1, 2025 at 6:26 PM
Sorry to hear. Has anything helped?
October 27, 2025 at 6:53 PM
Have you seen the other trends in other viral, bacterial and fungal infections?
October 27, 2025 at 2:11 AM
Good grief.
October 27, 2025 at 1:41 AM
Tissues from severe autopsied Covid cases showed reduced p53 expression and increased MDM2 or p21 dysregulation in lung and vascular endothelium. In ACE2-humanized mice and hamsters, infection reduced p53-responsive gene expression (e.g., CDKN1A, GADD45A) in lung tissue during peak viral replication
October 27, 2025 at 12:50 AM