@drrgjoneslab.bsky.social
In the current paper we report that LKB1 mutations promote "pathogenic" Th17 responses in the GI tract. Polyps from PJS mice are also enriched with IL-17-producing CD4+, CD8+, and gamma-delta T cells. Treatment of PJS mice with IL-17 blocking antibodies reduces GI polyp growth!
June 27, 2025 at 11:45 AM
In the current paper we report that LKB1 mutations promote "pathogenic" Th17 responses in the GI tract. Polyps from PJS mice are also enriched with IL-17-producing CD4+, CD8+, and gamma-delta T cells. Treatment of PJS mice with IL-17 blocking antibodies reduces GI polyp growth!