Michela Leocadi
@drmichelaleocadi.bsky.social
Reposted by Michela Leocadi
Amid this week’s huge milestone in #HD treatment, I’m excited to share part of my PhD thesis + our paper published today in @movedisorder.bsky.social on CSF #PENK predicting striatal atrophy decades before clinical motor diagnosis 🔗 movementdisorders.onlinelibrary.wiley.com/doi/10.1002/...
Cerebrospinal Fluid Proenkephalin Predicts Striatal Atrophy Decades before Clinical Motor Diagnosis in Huntington's Disease
Background Huntington's disease (HD) is characterized by early, selective, progressive vulnerability of striatal medium spiny neurons (MSNs). Proenkephalin (PENK), a precursor of opioid peptides abu...
movementdisorders.onlinelibrary.wiley.com
September 26, 2025 at 10:44 AM
Amid this week’s huge milestone in #HD treatment, I’m excited to share part of my PhD thesis + our paper published today in @movedisorder.bsky.social on CSF #PENK predicting striatal atrophy decades before clinical motor diagnosis 🔗 movementdisorders.onlinelibrary.wiley.com/doi/10.1002/...
Reposted by Michela Leocadi
For the first time, we show that baseline CSF PENK predicts longitudinal striatal atrophy and also outperforms NfL in distinguishing HD-ISS 0 vs 1, supporting CSF PENK as a striatum-specific biomarker to enrich early HD trials and inform future preventive trial design.
September 26, 2025 at 10:50 AM
For the first time, we show that baseline CSF PENK predicts longitudinal striatal atrophy and also outperforms NfL in distinguishing HD-ISS 0 vs 1, supporting CSF PENK as a striatum-specific biomarker to enrich early HD trials and inform future preventive trial design.
Reposted by Michela Leocadi
Huge thanks to @drmichelaleocadi.bsky.social and #HDYO for organising this fantastic event! Donate now and please support young people impacted by Huntington's disease: hdyo.enthuse.com/pf/huntingto...
🏃♀️ Run 4 HDYO Olivia (Liv) Martinez Scholarship Fund– 5K Charity Run/Walk at Battersea Park
📅 Saturday, June 28th, 2025 | 🕘 8:30 AM | 📍 Battersea Park, London (Carriage Drive West) Come join us for a 5K run or walk to raise awareness of Huntington’s Disease and support the amazing work of
hdyo.enthuse.com
June 28, 2025 at 5:08 PM
Huge thanks to @drmichelaleocadi.bsky.social and #HDYO for organising this fantastic event! Donate now and please support young people impacted by Huntington's disease: hdyo.enthuse.com/pf/huntingto...
Reposted by Michela Leocadi
Hot off the press! Check out the second edition of the @ehdn-news.bsky.social Imaging Working Group (#iWG) newsletter! #HD #neuroimaging @drmichelaleocadi.bsky.social @rachiscahill.bsky.social @nicolahobbs.bsky.social ehdn.org/wp-content/u...
ehdn.org
April 1, 2025 at 1:56 PM
Hot off the press! Check out the second edition of the @ehdn-news.bsky.social Imaging Working Group (#iWG) newsletter! #HD #neuroimaging @drmichelaleocadi.bsky.social @rachiscahill.bsky.social @nicolahobbs.bsky.social ehdn.org/wp-content/u...
Reposted by Michela Leocadi
UCL HD Centre @ucl-hd.bsky.social celebrating #HDGratitudeDay. Thanks to all the families and researchers around the world who together are trying to improve lives for people with Huntington’s disease.
March 24, 2025 at 4:42 PM
UCL HD Centre @ucl-hd.bsky.social celebrating #HDGratitudeDay. Thanks to all the families and researchers around the world who together are trying to improve lives for people with Huntington’s disease.
Reposted by Michela Leocadi
Our paper in Nature Medicine is out today! Great working with @drmfarag.bsky.social & the YAS team (researchers and participants) to identify biomarkers that pave the way for preventative trials in Huntington's Disease. Thanks to @wellcometrust.bsky.social and CHDI for funding. tinyurl.com/3fde9mth
January 17, 2025 at 3:31 PM
Our paper in Nature Medicine is out today! Great working with @drmfarag.bsky.social & the YAS team (researchers and participants) to identify biomarkers that pave the way for preventative trials in Huntington's Disease. Thanks to @wellcometrust.bsky.social and CHDI for funding. tinyurl.com/3fde9mth
Reposted by Michela Leocadi
Excited to share my joint first-author paper (with @rachiscahill.bsky.social) published today in Nature Medicine (@natmedicine.bsky.social, @nature.com). Our findings are timely as the #HD therapeutic landscape expands toward preventive clinical trials. 🔓 Open access: www.nature.com/articles/s41...
Somatic CAG repeat expansion in blood associates with biomarkers of neurodegeneration in Huntington’s disease decades before clinical motor diagnosis - Nature Medicine
A comprehensive longitudinal analysis of individuals with preclinical Huntington’s disease identifies biomarkers of neurodegeneration and somatic expansion in blood DNA, detectable years before sympto...
www.nature.com
January 17, 2025 at 11:00 AM
Excited to share my joint first-author paper (with @rachiscahill.bsky.social) published today in Nature Medicine (@natmedicine.bsky.social, @nature.com). Our findings are timely as the #HD therapeutic landscape expands toward preventive clinical trials. 🔓 Open access: www.nature.com/articles/s41...