Glenn Carrington
@drgcarrington.bsky.social
Postdoc in the Peckham Lab (University of Leeds) using Structural Biology & Molecular Dynamics to study all things myosin, kinesin, microtubules, and coiled coils. Views my own.
Reposted by Glenn Carrington
Cryo-EM structure of shutdown human non-muscle myosin 2A www.biorxiv.org/content/10.1101/2025.10.15.682586v1 #cryoem
October 16, 2025 at 7:12 AM
Cryo-EM structure of shutdown human non-muscle myosin 2A www.biorxiv.org/content/10.1101/2025.10.15.682586v1 #cryoem
Reposted by Glenn Carrington
Structure of the autoinhibited state of non-muscle myosin IIA - shows a different mechanism than seen for beta-cardiac myosin.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Cryo-EM structure of shutdown human non-muscle myosin 2A
Determining the high-resolution structure of the widely expressed non-muscle myosin 2A (NM2A), in its dephosphorylated shutdown state, is important in understanding its regulation and disease roles. I...
www.biorxiv.org
October 16, 2025 at 10:25 AM
Structure of the autoinhibited state of non-muscle myosin IIA - shows a different mechanism than seen for beta-cardiac myosin.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
🚨 New paper alert! 🧬
Excited to share our latest preprint from the @michellepeckham.bsky.social lab 🎉
We reveal the structure of human non-muscle myosin 2A — showing how ionic interactions control auto-inhibition ⚡ and how disease mutations disrupt it 💪
👉 tinyurl.com/4fkxfv4e
#cryoEM #myosin
Excited to share our latest preprint from the @michellepeckham.bsky.social lab 🎉
We reveal the structure of human non-muscle myosin 2A — showing how ionic interactions control auto-inhibition ⚡ and how disease mutations disrupt it 💪
👉 tinyurl.com/4fkxfv4e
#cryoEM #myosin
October 16, 2025 at 8:51 AM
🚨 New paper alert! 🧬
Excited to share our latest preprint from the @michellepeckham.bsky.social lab 🎉
We reveal the structure of human non-muscle myosin 2A — showing how ionic interactions control auto-inhibition ⚡ and how disease mutations disrupt it 💪
👉 tinyurl.com/4fkxfv4e
#cryoEM #myosin
Excited to share our latest preprint from the @michellepeckham.bsky.social lab 🎉
We reveal the structure of human non-muscle myosin 2A — showing how ionic interactions control auto-inhibition ⚡ and how disease mutations disrupt it 💪
👉 tinyurl.com/4fkxfv4e
#cryoEM #myosin
Reposted by Glenn Carrington
Happy to share the inaugural paper from the lab. We describe a molecular mechanism for the activation of outer dynein arm motors that power the vital motion of cilia.
Open access link below:
www.nature.com/articles/s41...
Here's a cool animated summary
Open access link below:
www.nature.com/articles/s41...
Here's a cool animated summary
September 29, 2025 at 7:09 PM
Happy to share the inaugural paper from the lab. We describe a molecular mechanism for the activation of outer dynein arm motors that power the vital motion of cilia.
Open access link below:
www.nature.com/articles/s41...
Here's a cool animated summary
Open access link below:
www.nature.com/articles/s41...
Here's a cool animated summary
Reposted by Glenn Carrington
Delighted to see Jon Machin's lovely OMP folding and assembly work on the front cover of JMB (doi: 10.1016/j.jmb.2025.169346) and in this Faraday Discussion article (doi: 10.1039/d4fd00180). Congratulations on your great work Jonathan!
August 30, 2025 at 12:15 PM
Delighted to see Jon Machin's lovely OMP folding and assembly work on the front cover of JMB (doi: 10.1016/j.jmb.2025.169346) and in this Faraday Discussion article (doi: 10.1039/d4fd00180). Congratulations on your great work Jonathan!
Reposted by Glenn Carrington
Thrilled to see our study on how kinesin-2 motors are switched on and off published in @natsmb.nature.com ⚛️
➡️ www.nature.com/articles/s41...
Congrats to all authors from me and Anthony 🎉 @dunnschool.bsky.social Check out this animation made by talented PhD student @matthew-batisio.bsky.social 😆
➡️ www.nature.com/articles/s41...
Congrats to all authors from me and Anthony 🎉 @dunnschool.bsky.social Check out this animation made by talented PhD student @matthew-batisio.bsky.social 😆
July 29, 2025 at 9:04 AM
Thrilled to see our study on how kinesin-2 motors are switched on and off published in @natsmb.nature.com ⚛️
➡️ www.nature.com/articles/s41...
Congrats to all authors from me and Anthony 🎉 @dunnschool.bsky.social Check out this animation made by talented PhD student @matthew-batisio.bsky.social 😆
➡️ www.nature.com/articles/s41...
Congrats to all authors from me and Anthony 🎉 @dunnschool.bsky.social Check out this animation made by talented PhD student @matthew-batisio.bsky.social 😆
Reposted by Glenn Carrington
Swinging lever mechanism of myosin shown by time-resolved cryoEM www.nature.com/articles/s41... so glad to finally be able to share this with the community! @astburycentre.bsky.social @astbury-bsl.bsky.social @stemuench.bsky.social @snmcmillan.bsky.social @davidklebl.bsky.social
Swinging lever mechanism of myosin directly shown by time-resolved cryo-EM - Nature
A study using time-resolved cryogenic electron microscopy reveals the swinging lever mechanism of myosin, providing information on the molecular basis behind the production of force and movement by my...
www.nature.com
April 9, 2025 at 5:19 PM
Swinging lever mechanism of myosin shown by time-resolved cryoEM www.nature.com/articles/s41... so glad to finally be able to share this with the community! @astburycentre.bsky.social @astbury-bsl.bsky.social @stemuench.bsky.social @snmcmillan.bsky.social @davidklebl.bsky.social
Reposted by Glenn Carrington
👋👋 Hi everyone! The Astbury Centre is now on Bluesky. Follow along for updates about exciting Astbury Centre science. For now, we have put together a starter pack of members of the Astbury Centre community.
January 23, 2025 at 2:37 PM
👋👋 Hi everyone! The Astbury Centre is now on Bluesky. Follow along for updates about exciting Astbury Centre science. For now, we have put together a starter pack of members of the Astbury Centre community.
Reposted by Glenn Carrington
We have a new 4-year postdoctoral position available working between our lab at the Woolfson lab at Schools of Biochemistry and Chemistry at Bristol. Applying protein design approaches to control intracellular transport. More info on link and flyer. Get in touch! www.bristol.ac.uk/jobs/find/de...
January 9, 2025 at 3:59 PM
We have a new 4-year postdoctoral position available working between our lab at the Woolfson lab at Schools of Biochemistry and Chemistry at Bristol. Applying protein design approaches to control intracellular transport. More info on link and flyer. Get in touch! www.bristol.ac.uk/jobs/find/de...
Reposted by Glenn Carrington
PhD studentship available! #AstburyCentre CryoEM & MD simulation to understand cardiac muscle function in health and disease Apply by 5th Jan www.findaphd.com/phds/project...
Unravelling the mechanisms of cardiac myosin function in health and disease through molecular dynamic simulation and electron microscopy at University of Leeds on FindAPhD.com
PhD Project - Unravelling the mechanisms of cardiac myosin function in health and disease through molecular dynamic simulation and electron microscopy at University of Leeds, listed on FindAPhD.com
www.findaphd.com
November 19, 2024 at 12:03 PM
PhD studentship available! #AstburyCentre CryoEM & MD simulation to understand cardiac muscle function in health and disease Apply by 5th Jan www.findaphd.com/phds/project...