Prion spongiosis: the sponge-like appearance of #prion affected brain tissue when viewed under a microscope. Resulting from the formation of tiny, round vacuoles (holes) in the neuropil (the dense network of neurons and glial cells) and within neuronal cell bodies.

Amyloid meaning starch or cellulose like described by Virchow (1851). Ordered protein aggregates that bind certain compounds such as Thioflavin. Shown here fluorescent #microscopy image of Chronic Wasting Disease #prions florid (flower-like) #amyloid plaque in the brain [bright green]