@drandrewloblaw.bsky.social
GU Radiation Oncologist and Disease Site Group Lead @Sunnybrook.
This is something I don’t really get.
Huge and sustained difference in bDFS with FLAME when average D98 was 85/37 to DIL (curves start separating at 1y!). Bravo 👏🏻
But with PACE B where whole prostate (including DIL) had D98 of over 100Gy EQD2 but only small improvement (nss)
Can anyone explain?
Huge and sustained difference in bDFS with FLAME when average D98 was 85/37 to DIL (curves start separating at 1y!). Bravo 👏🏻
But with PACE B where whole prostate (including DIL) had D98 of over 100Gy EQD2 but only small improvement (nss)
Can anyone explain?
Significant benefit to focal boost in prostate cancer out to 10 years in FLAME trial #ESTRO2025 Fifteen percent of men avoid further treatment just due to the boost 🏆
May 5, 2025 at 11:49 AM
This is something I don’t really get.
Huge and sustained difference in bDFS with FLAME when average D98 was 85/37 to DIL (curves start separating at 1y!). Bravo 👏🏻
But with PACE B where whole prostate (including DIL) had D98 of over 100Gy EQD2 but only small improvement (nss)
Can anyone explain?
Huge and sustained difference in bDFS with FLAME when average D98 was 85/37 to DIL (curves start separating at 1y!). Bravo 👏🏻
But with PACE B where whole prostate (including DIL) had D98 of over 100Gy EQD2 but only small improvement (nss)
Can anyone explain?
We saw the same trend in #PACE B (HR around 0.75 if I recall favouring #SBRT). Only time will tell if difference holds and becomes statistically significant.
HYPO-RT-PC 10 year data presented at #ESTRO2025. Seven fractions def non-inferior to 39 fractions, suggestion that 7 fractions might even be more likely to cure?
May 5, 2025 at 11:43 AM
Wee Ong leads pub in @EurUrolOncol for #PATRIOT (#SBRT weekly vs every other day treatment for favourable risk #prostatecancer )
No stat diff in bioc fail (mFU of 91mo)
Planning to combine with @ZilliThomas #NOVALIS study (same design)
free link👉tinyurl.com/yyhd69c2
No stat diff in bioc fail (mFU of 91mo)
Planning to combine with @ZilliThomas #NOVALIS study (same design)
free link👉tinyurl.com/yyhd69c2
April 27, 2025 at 8:48 PM
Wee Ong leads pub in @EurUrolOncol for #PATRIOT (#SBRT weekly vs every other day treatment for favourable risk #prostatecancer )
No stat diff in bioc fail (mFU of 91mo)
Planning to combine with @ZilliThomas #NOVALIS study (same design)
free link👉tinyurl.com/yyhd69c2
No stat diff in bioc fail (mFU of 91mo)
Planning to combine with @ZilliThomas #NOVALIS study (same design)
free link👉tinyurl.com/yyhd69c2
Reposted
What’s stunning is that nothing is being done about it! Hegseth should be fired - at least he won’t need to feel guilty about his #DayDrinking
On @CNN.com this afternoon with Brianna Keilar and Boris Sanchez discussing stunning story about administration Signal security breach. youtu.be/BZdIIboc1GQ
ADM STAV ON CNN NEWS CENTRAL 3 24 25
YouTube video by ADM STAV VIDEOS
youtu.be
March 27, 2025 at 4:05 PM
What’s stunning is that nothing is being done about it! Hegseth should be fired - at least he won’t need to feel guilty about his #DayDrinking
This will be a game changer!
Much (10x) cheaper than MRI, no room shielding / purge requirements, no special safety training.
In Canada no US restrictions (unlike MRI).
PS I have no COI with this company.
Much (10x) cheaper than MRI, no room shielding / purge requirements, no special safety training.
In Canada no US restrictions (unlike MRI).
PS I have no COI with this company.
Microultrasonography-Guided vs MRI-Guided Biopsy for Prostate Cancer Diagnosis: The OPTIMUM Randomized Clinical Trial
jamanetwork.com/journals/jam...
These findings suggest that microultrasonography could serve as an alternative to MRI for prostate cancer diagnosis.
#ProstateCancer
jamanetwork.com/journals/jam...
These findings suggest that microultrasonography could serve as an alternative to MRI for prostate cancer diagnosis.
#ProstateCancer
Microultrasonography-Guided vs MRI-Guided Biopsy for Prostate Cancer Diagnosis
This randomized, noninferiority trial of biopsy-naive men compares the detection of Gleason Grade Group ≥2 prostate cancer using microultrasonography-guided and MRI fusion-guided biopsy.
jamanetwork.com
March 27, 2025 at 4:01 PM
This will be a game changer!
Much (10x) cheaper than MRI, no room shielding / purge requirements, no special safety training.
In Canada no US restrictions (unlike MRI).
PS I have no COI with this company.
Much (10x) cheaper than MRI, no room shielding / purge requirements, no special safety training.
In Canada no US restrictions (unlike MRI).
PS I have no COI with this company.
Reposted
March 23, 2025 at 6:00 PM
This is a dozen eggs in Canada
In Canadian $!
That $2.79 US
In Canadian $!
That $2.79 US
March 24, 2025 at 6:20 PM
This is a dozen eggs in Canada
In Canadian $!
That $2.79 US
In Canadian $!
That $2.79 US
Assistant to Associate (Rad Onc and Epidemiology at University of Toronto): 7y
Associate to Full Prof (for both): 7y
Associate to Full Prof (for both): 7y
Academics of Bluesky, I have a question for you:
How long did it take you to apply for a promotion from Lecturer (Assistant Prof) to Senior Lecturer (Associate Prof)? And what is your gender?
Were you encouraged or discouraged?
Comment below 👇
#AcademicSky #AcademicChatter
How long did it take you to apply for a promotion from Lecturer (Assistant Prof) to Senior Lecturer (Associate Prof)? And what is your gender?
Were you encouraged or discouraged?
Comment below 👇
#AcademicSky #AcademicChatter
March 16, 2025 at 12:46 PM
Assistant to Associate (Rad Onc and Epidemiology at University of Toronto): 7y
Associate to Full Prof (for both): 7y
Associate to Full Prof (for both): 7y
Behind in many ways but maybe ahead in a few
It’s a no-brainer @drandrewloblaw.bsky.social , any treatment that increases cure rates should be approved, no questions asked. Canada ahead of us again!
March 15, 2025 at 8:05 PM
Behind in many ways but maybe ahead in a few
Reposted
It’s a no-brainer @drandrewloblaw.bsky.social , any treatment that increases cure rates should be approved, no questions asked. Canada ahead of us again!
March 15, 2025 at 11:09 AM
It’s a no-brainer @drandrewloblaw.bsky.social , any treatment that increases cure rates should be approved, no questions asked. Canada ahead of us again!
Fortunately in Ontario Canada abi is available through general formulary (no forms or special application - same as an antibiotic!)
Only Cdn$30 per day!
Great for patients and the healthcare system
Only Cdn$30 per day!
Great for patients and the healthcare system
Really shameful that more than 2 years after we learned that Abiraterone, an inexpensive medicine, saves lives, it is STILL not available in the English NHS. Thanks @prostatecanceruk.bsky.social for highlighting the struggle many men, and their doctors, are facing.
www.bbc.com/news/article...
www.bbc.com/news/article...
www.bbc.com
March 14, 2025 at 9:18 PM
Fortunately in Ontario Canada abi is available through general formulary (no forms or special application - same as an antibiotic!)
Only Cdn$30 per day!
Great for patients and the healthcare system
Only Cdn$30 per day!
Great for patients and the healthcare system
Elon Musk has lost US$700 billion market cap in 3 months. Trump has been bankrupt like 10 times?
Why would anyone believe they could run one of the world’s largest economies?
Why would anyone believe they could run one of the world’s largest economies?
March 11, 2025 at 10:14 PM
Elon Musk has lost US$700 billion market cap in 3 months. Trump has been bankrupt like 10 times?
Why would anyone believe they could run one of the world’s largest economies?
Why would anyone believe they could run one of the world’s largest economies?
There is a second screen for prostate cancer (MRI): I call it a “manogram”
they should make vitamins for men. vitamen
they should make robitussin for men. brobitussin
February 27, 2025 at 12:17 PM
There is a second screen for prostate cancer (MRI): I call it a “manogram”
Reposted
they should make vitamins for men. vitamen
they should make robitussin for men. brobitussin
February 27, 2025 at 4:55 AM
they should make vitamins for men. vitamen
So powerful! We need more voices to find the “ocean of truth”
Here it is. We are in our documentary moment. Watch it. I stand for #science.
February 25, 2025 at 5:31 PM
So powerful! We need more voices to find the “ocean of truth”
Reposted
Oncological Safety of MRI-Informed Biopsy Decision-Making in Men W/ Suspected #ProstateCancer
jamanetwork.com/journals/jam...
Study finds men w/ negative MRI who avoided biopsy were not at increased risk of csPCa, supporting safety of an MRI-1st diagnostic approach when combined with systematic FU
jamanetwork.com/journals/jam...
Study finds men w/ negative MRI who avoided biopsy were not at increased risk of csPCa, supporting safety of an MRI-1st diagnostic approach when combined with systematic FU
Oncological Safety of MRI-Informed Biopsy Decision-Making in Men With Suspected Prostate Cancer
This cohort study assesses the feasibility and safety of a community-based magnetic resonance imaging (MRI) diagnostic strategy in men with suspected prostate cancer using 3-year active monitoring.
jamanetwork.com
February 25, 2025 at 11:48 AM
Oncological Safety of MRI-Informed Biopsy Decision-Making in Men W/ Suspected #ProstateCancer
jamanetwork.com/journals/jam...
Study finds men w/ negative MRI who avoided biopsy were not at increased risk of csPCa, supporting safety of an MRI-1st diagnostic approach when combined with systematic FU
jamanetwork.com/journals/jam...
Study finds men w/ negative MRI who avoided biopsy were not at increased risk of csPCa, supporting safety of an MRI-1st diagnostic approach when combined with systematic FU
Reposted
Trends in #ProstateCancer Incidence and Mortality Rates Out on JAMA Network
jamanetwork.com/journals/jam...
Findings underscore need for improved prostate cancer screening strategies to address the rising incidence of distant-stage disease
Ping
@yukselurun.bsky.social
@barbaramelao.bsky.social
jamanetwork.com/journals/jam...
Findings underscore need for improved prostate cancer screening strategies to address the rising incidence of distant-stage disease
Ping
@yukselurun.bsky.social
@barbaramelao.bsky.social
Trends in Prostate Cancer Incidence and Mortality Rates
This cohort study examines the trends in prostate cancer incidence and mortality rates in California by stage, age, race and ethnicity, and region of California.
jamanetwork.com
February 20, 2025 at 11:38 AM
Trends in #ProstateCancer Incidence and Mortality Rates Out on JAMA Network
jamanetwork.com/journals/jam...
Findings underscore need for improved prostate cancer screening strategies to address the rising incidence of distant-stage disease
Ping
@yukselurun.bsky.social
@barbaramelao.bsky.social
jamanetwork.com/journals/jam...
Findings underscore need for improved prostate cancer screening strategies to address the rising incidence of distant-stage disease
Ping
@yukselurun.bsky.social
@barbaramelao.bsky.social
Sorry forgot to add - those with GG2 and APP4 < 1% are safe to follow!
DOI: 10.1016/j.radonc.2023.109859
DOI: 10.1016/j.radonc.2023.109859
Almost all guidelines recommend active surveillance for low and selected int risk #ProstateCancer
But no one tells you the IR pts that are safe… until now
Over 1500 pts, >10y mFU: absolute % pattern 4/5 has same MFS as GG1 ds
Ruben del Castillo presented at #GU25 & awarded @asco Award of Merit
But no one tells you the IR pts that are safe… until now
Over 1500 pts, >10y mFU: absolute % pattern 4/5 has same MFS as GG1 ds
Ruben del Castillo presented at #GU25 & awarded @asco Award of Merit
February 15, 2025 at 9:17 PM
Sorry forgot to add - those with GG2 and APP4 < 1% are safe to follow!
DOI: 10.1016/j.radonc.2023.109859
DOI: 10.1016/j.radonc.2023.109859
Reposted
Almost all guidelines recommend active surveillance for low and selected int risk #ProstateCancer
But no one tells you the IR pts that are safe… until now
Over 1500 pts, >10y mFU: absolute % pattern 4/5 has same MFS as GG1 ds
Ruben del Castillo presented at #GU25 & awarded @asco Award of Merit
But no one tells you the IR pts that are safe… until now
Over 1500 pts, >10y mFU: absolute % pattern 4/5 has same MFS as GG1 ds
Ruben del Castillo presented at #GU25 & awarded @asco Award of Merit
February 15, 2025 at 4:19 PM
Almost all guidelines recommend active surveillance for low and selected int risk #ProstateCancer
But no one tells you the IR pts that are safe… until now
Over 1500 pts, >10y mFU: absolute % pattern 4/5 has same MFS as GG1 ds
Ruben del Castillo presented at #GU25 & awarded @asco Award of Merit
But no one tells you the IR pts that are safe… until now
Over 1500 pts, >10y mFU: absolute % pattern 4/5 has same MFS as GG1 ds
Ruben del Castillo presented at #GU25 & awarded @asco Award of Merit
@sunnybrook we made a few videos to help people learn #Transperineal biopsies (and gold fiducial insertion).
👇🏻 check them out‼️
1. Local anesthesia: youtu.be/dQLRnAIuSVI?si…
2. Gold seed insertion: youtu.be/uOb4CEBAdmY?si���
3. TP biopsy: youtu.be/TtjRebJxvvQ?si…
👇🏻 check them out‼️
1. Local anesthesia: youtu.be/dQLRnAIuSVI?si…
2. Gold seed insertion: youtu.be/uOb4CEBAdmY?si���
3. TP biopsy: youtu.be/TtjRebJxvvQ?si…
Transperineal Procedure - Gold seed Insertion or TP Biopsy. #1
YouTube video by Sunnybrook Hospital
https://youtu.be/dQLRnAIuSVI?si…
February 15, 2025 at 7:25 PM
@sunnybrook we made a few videos to help people learn #Transperineal biopsies (and gold fiducial insertion).
👇🏻 check them out‼️
1. Local anesthesia: youtu.be/dQLRnAIuSVI?si…
2. Gold seed insertion: youtu.be/uOb4CEBAdmY?si���
3. TP biopsy: youtu.be/TtjRebJxvvQ?si…
👇🏻 check them out‼️
1. Local anesthesia: youtu.be/dQLRnAIuSVI?si…
2. Gold seed insertion: youtu.be/uOb4CEBAdmY?si���
3. TP biopsy: youtu.be/TtjRebJxvvQ?si…
Reposted
Our review on the promise of #radiotherapy in #NMIBC #Openaccess #WhereisHoskin @mcrcnews.bsky.social @oncoalert.bsky.social @southamptonctu.bsky.social #TRAINTrial
www.mdpi.com/2072-6694/17...
www.mdpi.com/2072-6694/17...
The Promise of Radiotherapy in High-Risk Non-Muscle Invasive Bladder Cancer
Global shortages, toxicities, and high levels of incomplete treatment with Bacillus Calmette Guerin (BCG) for non-muscle invasive bladder cancer has resulted in increasing interest in alternative trea...
www.mdpi.com
February 13, 2025 at 9:33 AM
Our review on the promise of #radiotherapy in #NMIBC #Openaccess #WhereisHoskin @mcrcnews.bsky.social @oncoalert.bsky.social @southamptonctu.bsky.social #TRAINTrial
www.mdpi.com/2072-6694/17...
www.mdpi.com/2072-6694/17...
Almost all guidelines recommend active surveillance for low and selected int risk #ProstateCancer
But no one tells you the IR pts that are safe… until now
Over 1500 pts, >10y mFU: absolute % pattern 4/5 has same MFS as GG1 ds
Ruben del Castillo presented at #GU25 & awarded @asco Award of Merit
But no one tells you the IR pts that are safe… until now
Over 1500 pts, >10y mFU: absolute % pattern 4/5 has same MFS as GG1 ds
Ruben del Castillo presented at #GU25 & awarded @asco Award of Merit
February 15, 2025 at 4:19 PM
Almost all guidelines recommend active surveillance for low and selected int risk #ProstateCancer
But no one tells you the IR pts that are safe… until now
Over 1500 pts, >10y mFU: absolute % pattern 4/5 has same MFS as GG1 ds
Ruben del Castillo presented at #GU25 & awarded @asco Award of Merit
But no one tells you the IR pts that are safe… until now
Over 1500 pts, >10y mFU: absolute % pattern 4/5 has same MFS as GG1 ds
Ruben del Castillo presented at #GU25 & awarded @asco Award of Merit