Ashley Dalrymple
@dr-shlee.bsky.social
Neural engineer: Spinal cord stimulation⚡️, sensorimotor systems, control, rehabilitation🦿👩🦽🚶♀️ Thoughts=mine
It rarely happens these days, but I managed to clear my inbox! I keep all unanswered emails in my inbox, and immediately file them away into folders once I have responded. It pains me to have an inbox that fills 1 page on my screen.
It will probably last for 5 minutes, but I will take the win!
It will probably last for 5 minutes, but I will take the win!
July 11, 2025 at 5:26 PM
It rarely happens these days, but I managed to clear my inbox! I keep all unanswered emails in my inbox, and immediately file them away into folders once I have responded. It pains me to have an inbox that fills 1 page on my screen.
It will probably last for 5 minutes, but I will take the win!
It will probably last for 5 minutes, but I will take the win!
Spotted: Uber and Lyft drivers hanging out together in a parking lot, but not accepting ride requests. They're likely working together to time-out requests so that demand looks higher than it is, driving up prices.
May 25, 2025 at 10:50 PM
Spotted: Uber and Lyft drivers hanging out together in a parking lot, but not accepting ride requests. They're likely working together to time-out requests so that demand looks higher than it is, driving up prices.
if you weren't touched by Scott's talk about his experience using motor and sensory BCI, did you even attend IFESS at #RehabWeek2025?
See what I did there?
See what I did there?
May 14, 2025 at 10:25 PM
if you weren't touched by Scott's talk about his experience using motor and sensory BCI, did you even attend IFESS at #RehabWeek2025?
See what I did there?
See what I did there?
This past week has been quite eventful for the NERVES Lab!⚡️🔥
Our BME undergraduate student, Chimdi, graduated!! 👩🎓
PhD student, Abby, proposed her thesis and became a PhD Candidate!! 🦾
I am a #proudPI 🫶
Our BME undergraduate student, Chimdi, graduated!! 👩🎓
PhD student, Abby, proposed her thesis and became a PhD Candidate!! 🦾
I am a #proudPI 🫶
May 10, 2025 at 1:27 AM
This past week has been quite eventful for the NERVES Lab!⚡️🔥
Our BME undergraduate student, Chimdi, graduated!! 👩🎓
PhD student, Abby, proposed her thesis and became a PhD Candidate!! 🦾
I am a #proudPI 🫶
Our BME undergraduate student, Chimdi, graduated!! 👩🎓
PhD student, Abby, proposed her thesis and became a PhD Candidate!! 🦾
I am a #proudPI 🫶
At the iBCI workshop at #ASNR2025! We are enjoying a stimulating discussion of the development of clinical practice guidelines for implantable BCIs over some tender steak, hummingbird cake, and Georgia peach sweet tea 🍑🍹
Bonus: I got to catch up with colleague and speaker Adam Fry from Synchron!
Bonus: I got to catch up with colleague and speaker Adam Fry from Synchron!
April 22, 2025 at 10:52 PM
At the iBCI workshop at #ASNR2025! We are enjoying a stimulating discussion of the development of clinical practice guidelines for implantable BCIs over some tender steak, hummingbird cake, and Georgia peach sweet tea 🍑🍹
Bonus: I got to catch up with colleague and speaker Adam Fry from Synchron!
Bonus: I got to catch up with colleague and speaker Adam Fry from Synchron!
Last weekend, the NERVES Lab went to Colorado for the Rocky Mountain American Society of Biomechanics!
Our students presented 6 posters! Huge congrants to PhD student @sonny-jones.bsky.social for winning a prize for best PhD poster in his session.
Also, check out the NERVES Mobile!
Our students presented 6 posters! Huge congrants to PhD student @sonny-jones.bsky.social for winning a prize for best PhD poster in his session.
Also, check out the NERVES Mobile!
April 19, 2025 at 4:34 AM
Last weekend, the NERVES Lab went to Colorado for the Rocky Mountain American Society of Biomechanics!
Our students presented 6 posters! Huge congrants to PhD student @sonny-jones.bsky.social for winning a prize for best PhD poster in his session.
Also, check out the NERVES Mobile!
Our students presented 6 posters! Huge congrants to PhD student @sonny-jones.bsky.social for winning a prize for best PhD poster in his session.
Also, check out the NERVES Mobile!
We are just a couple of weeks away from #ASNR2025! We have an excellent panel (among many) discussing our current understanding & remaining questions around transcutaneous SCS for rehab
This will be my first time in Atlanta. I hope to see you there! I'll be drinking sweet tea🍹
@asnrehab.bsky.social
This will be my first time in Atlanta. I hope to see you there! I'll be drinking sweet tea🍹
@asnrehab.bsky.social
April 7, 2025 at 6:47 PM
We are just a couple of weeks away from #ASNR2025! We have an excellent panel (among many) discussing our current understanding & remaining questions around transcutaneous SCS for rehab
This will be my first time in Atlanta. I hope to see you there! I'll be drinking sweet tea🍹
@asnrehab.bsky.social
This will be my first time in Atlanta. I hope to see you there! I'll be drinking sweet tea🍹
@asnrehab.bsky.social
12 years ago I received my iron ring. Here are my 2 favourite people who joined me for the ceremony.
Also, I'm so glad eyebrows are back in style.
Also, I'm so glad eyebrows are back in style.
April 6, 2025 at 6:30 PM
12 years ago I received my iron ring. Here are my 2 favourite people who joined me for the ceremony.
Also, I'm so glad eyebrows are back in style.
Also, I'm so glad eyebrows are back in style.
Another win for the NERVES Lab!
Chimdi won a prize for her beautiful graphics on her poster at the Undergraduate Research Symposium 😍
Chimdi won a prize for her beautiful graphics on her poster at the Undergraduate Research Symposium 😍
April 2, 2025 at 5:20 PM
Another win for the NERVES Lab!
Chimdi won a prize for her beautiful graphics on her poster at the Undergraduate Research Symposium 😍
Chimdi won a prize for her beautiful graphics on her poster at the Undergraduate Research Symposium 😍
Pro tip: hire a team as silly as you are.
The purpose of this magnet will be disclosed soon 👀
The purpose of this magnet will be disclosed soon 👀
March 29, 2025 at 2:20 AM
Pro tip: hire a team as silly as you are.
The purpose of this magnet will be disclosed soon 👀
The purpose of this magnet will be disclosed soon 👀
We had Dr. @helenhuang.bsky.social visit us for the BME Seminar on Friday at UUtah. She literally filled the room, the fullest it's been. Her talk about how to achieve a symbiotic relationship between a person and a lower-limb prosthesis using automatically adapting control strategies was inspiring.
March 23, 2025 at 2:57 PM
We had Dr. @helenhuang.bsky.social visit us for the BME Seminar on Friday at UUtah. She literally filled the room, the fullest it's been. Her talk about how to achieve a symbiotic relationship between a person and a lower-limb prosthesis using automatically adapting control strategies was inspiring.
If you're racing to beat the early bird deadline for RehabWeek, don't forget to register for our workshop! It's going to be very stimulating⚡ (that pun never gets old!)
Kilohertz Carrier Frequencies for Transcutaneous Spinal Cord Stimulation: What’s All The Buzz About?
Kilohertz Carrier Frequencies for Transcutaneous Spinal Cord Stimulation: What’s All The Buzz About?
March 18, 2025 at 10:00 PM
If you're racing to beat the early bird deadline for RehabWeek, don't forget to register for our workshop! It's going to be very stimulating⚡ (that pun never gets old!)
Kilohertz Carrier Frequencies for Transcutaneous Spinal Cord Stimulation: What’s All The Buzz About?
Kilohertz Carrier Frequencies for Transcutaneous Spinal Cord Stimulation: What’s All The Buzz About?
The Other Side of the Door includes other logistics such as data storage and programming. With increased complexity and channel count, data security and storage need to be addressed. Further, control strategies for programming devices need to be developed to avoid a Glitch.
March 17, 2025 at 3:15 PM
The Other Side of the Door includes other logistics such as data storage and programming. With increased complexity and channel count, data security and storage need to be addressed. Further, control strategies for programming devices need to be developed to avoid a Glitch.
Novel materials, bioactive agents, surgical approaches, and testing modalities are being developed to address failure modes. These goals are Bigger than the Whole Sky, but not Untouchable to ensure neural interfaces last Forever and Always and appear Invisible to the tissue.
March 17, 2025 at 3:15 PM
Novel materials, bioactive agents, surgical approaches, and testing modalities are being developed to address failure modes. These goals are Bigger than the Whole Sky, but not Untouchable to ensure neural interfaces last Forever and Always and appear Invisible to the tissue.
Thorough testing is critical to ensure that novel implanted neural interfaces Long Live. We describe methods for benchtop, in vivo, and post-explant testing. From this testing, it may be necessary to Change the implant design, and Begin Again, before you’re Out of the Woods.
March 17, 2025 at 3:15 PM
Thorough testing is critical to ensure that novel implanted neural interfaces Long Live. We describe methods for benchtop, in vivo, and post-explant testing. From this testing, it may be necessary to Change the implant design, and Begin Again, before you’re Out of the Woods.
When a complication arises from failure of an implanted neural interface, understanding the severity is critical to guide clinical decision-making. We created a system to grade the severity of these complications, including examples. Upon treatment, Soon You’ll Get Better.
March 17, 2025 at 3:15 PM
When a complication arises from failure of an implanted neural interface, understanding the severity is critical to guide clinical decision-making. We created a system to grade the severity of these complications, including examples. Upon treatment, Soon You’ll Get Better.
The End Game is clinical translation of implanted neural interfaces. Importantly, failure modes have clinical implications and risks. Adverse events due to the surgical procedure, as well as those related to failure modes, are reported below for various neural interfaces.
March 17, 2025 at 3:15 PM
The End Game is clinical translation of implanted neural interfaces. Importantly, failure modes have clinical implications and risks. Adverse events due to the surgical procedure, as well as those related to failure modes, are reported below for various neural interfaces.
The tissue response & micromotion contribute to neuronal degeneration and loss near the implant site. Decreased neuronal density reduces therapeutic effects because neural interfaces rely on communication between the electrodes and neurons. We are Haunted by this High Infidelity.
March 17, 2025 at 3:15 PM
The tissue response & micromotion contribute to neuronal degeneration and loss near the implant site. Decreased neuronal density reduces therapeutic effects because neural interfaces rely on communication between the electrodes and neurons. We are Haunted by this High Infidelity.
Micromotion is subtle movement of the implant from respiration, heartbeat, or changes in blood or cerebrospinal fluid pressure. Tissue damage is worsened by implant-tissue stiffness mismatch. Sharp electrode tips evoke a strong tissue response, inducing Death by a Thousand Cuts.
March 17, 2025 at 3:15 PM
Micromotion is subtle movement of the implant from respiration, heartbeat, or changes in blood or cerebrospinal fluid pressure. Tissue damage is worsened by implant-tissue stiffness mismatch. Sharp electrode tips evoke a strong tissue response, inducing Death by a Thousand Cuts.
Macro-motion of the device relative to neural tissue can result from limb movement or even spinal cord movement relative to the spine. It’s frustrating, because All They Had to Do Was Stay. Stay Stay Stay. If devices are completely removed, We Are Never Getting Back Together.
March 17, 2025 at 3:15 PM
Macro-motion of the device relative to neural tissue can result from limb movement or even spinal cord movement relative to the spine. It’s frustrating, because All They Had to Do Was Stay. Stay Stay Stay. If devices are completely removed, We Are Never Getting Back Together.
Migration of lead wires and implanted electrodes can occur if there is any tension on the lead wires, or in response to gravity. This can lead to reduce or lost efficacy, or off-target stimulation.
March 17, 2025 at 3:15 PM
Migration of lead wires and implanted electrodes can occur if there is any tension on the lead wires, or in response to gravity. This can lead to reduce or lost efficacy, or off-target stimulation.
For biocompatible materials, the scar formation will stabilize, resulting in device encapsulation or Closure, keeping it Safe & Sound. Unable to digest the materials, That’s When a protective barrier isolates the device from the neural tissue, and you can’t just Shake It Off.
March 17, 2025 at 3:15 PM
For biocompatible materials, the scar formation will stabilize, resulting in device encapsulation or Closure, keeping it Safe & Sound. Unable to digest the materials, That’s When a protective barrier isolates the device from the neural tissue, and you can’t just Shake It Off.
Macrophage and lymphocyte infiltration marks the chronic phase in the PNS (~1-2 Fortnights). These cells attempt to degrade the implant. Fibroblasts form granulation (scar) tissue around the implant. This scar increases impedance at the electrode-tissue interface.
March 17, 2025 at 3:15 PM
Macrophage and lymphocyte infiltration marks the chronic phase in the PNS (~1-2 Fortnights). These cells attempt to degrade the implant. Fibroblasts form granulation (scar) tissue around the implant. This scar increases impedance at the electrode-tissue interface.
Sub-acutely, Fearless mast cells enter the implant site and degranulate, releasing histamine and inflammatory cytokines that recruit phagocytes such as neutrophils and macrophages to the implant site.
March 17, 2025 at 3:15 PM
Sub-acutely, Fearless mast cells enter the implant site and degranulate, releasing histamine and inflammatory cytokines that recruit phagocytes such as neutrophils and macrophages to the implant site.
PNS implants cause neural and vascular trauma, which can lead to hematomas or infection. Acutely, blood plasma proteins adsorb, forming a provisional matrix around the implant that develops into a fibrin clot. Neutrophils phagocytose debris, making the site Clean.
March 17, 2025 at 3:15 PM
PNS implants cause neural and vascular trauma, which can lead to hematomas or infection. Acutely, blood plasma proteins adsorb, forming a provisional matrix around the implant that develops into a fibrin clot. Neutrophils phagocytose debris, making the site Clean.