Dominique Langin
@dominiquelangin.bsky.social
Adipocyte Metabolism Obesity Diabetes. Professor Faculty of Medicine @ UT3 & CHU Toulouse. Director Institute of Metabolic and Cardiovascular Diseases I2MC @ Inserm & UT3. PI ERC Synergy SPHERES
Reposted by Dominique Langin
#NatMetabPicks | In @cp-cellmetabolism.bsky.social led by @dominiquelangin.bsky.social ( @inserm.fr )
Hormone-sensitive lipase localizes to the nucleus in adipocytes and regulates adipose tissue homeostasis independently of its cytosolic function.
🧪
www.cell.com/cell-metabol...
Hormone-sensitive lipase localizes to the nucleus in adipocytes and regulates adipose tissue homeostasis independently of its cytosolic function.
🧪
www.cell.com/cell-metabol...
Nuclear hormone-sensitive lipase regulates adipose tissue mass and adipocyte metabolism
Dufau, Recazens, et al. identified the neutral lipase HSL in the nucleus of adipocytes,
where it modulates gene expression. The trafficking of HSL between the nucleus and
the cytosol is under the cont...
www.cell.com
November 3, 2025 at 3:40 PM
#NatMetabPicks | In @cp-cellmetabolism.bsky.social led by @dominiquelangin.bsky.social ( @inserm.fr )
Hormone-sensitive lipase localizes to the nucleus in adipocytes and regulates adipose tissue homeostasis independently of its cytosolic function.
🧪
www.cell.com/cell-metabol...
Hormone-sensitive lipase localizes to the nucleus in adipocytes and regulates adipose tissue homeostasis independently of its cytosolic function.
🧪
www.cell.com/cell-metabol...
Reposted by Dominique Langin
Online now: Nuclear hormone-sensitive lipase regulates adipose tissue mass and adipocyte metabolism
Nuclear hormone-sensitive lipase regulates adipose tissue mass and adipocyte metabolism
Dufau, Recazens, et al. identified the neutral lipase HSL in the nucleus of adipocytes, where it modulates gene expression. The trafficking of HSL between the nucleus and the cytosol is under the control of TGF-β and catecholamine signaling. In vivo, the presence of nuclear HSL is crucial for adipose tissue development.
dlvr.it
October 23, 2025 at 6:50 PM
Online now: Nuclear hormone-sensitive lipase regulates adipose tissue mass and adipocyte metabolism
Reposted by Dominique Langin
Persistance dans le tissu adipeux d’une mémoire épigénétique de l’obésité après perte de poids
A lire sur 'Le diabète dans tous ses états'
www.le-diabete-dans-tous-ses-etats.precidiab.org/obesite/pers...
A lire sur 'Le diabète dans tous ses états'
www.le-diabete-dans-tous-ses-etats.precidiab.org/obesite/pers...
Persistance dans le tissu adipeux d’une mémoire épigénétique de l’obésité après perte de poids - Le Diabète dans tous ses états
Toutes les personnes ayant perdu du poids, via des mesures hygiéno-diététiques, un traitement médical ou une chirurgie bariatrique, le savent que trop bien : elles risquent rapidement de reprendre du ...
www.le-diabete-dans-tous-ses-etats.precidiab.org
December 4, 2024 at 12:34 PM
Persistance dans le tissu adipeux d’une mémoire épigénétique de l’obésité après perte de poids
A lire sur 'Le diabète dans tous ses états'
www.le-diabete-dans-tous-ses-etats.precidiab.org/obesite/pers...
A lire sur 'Le diabète dans tous ses états'
www.le-diabete-dans-tous-ses-etats.precidiab.org/obesite/pers...
Reposted by Dominique Langin
First post! Didn't see this study on @bsky.app.
From @zgerharthines.bsky.social group identifying neuronal NK2R as a regulator of feeding/hunger & energy expenditure, and demonstrating the efficacy of a small molecule agonist in non-human primates for weight loss.
www.nature.com/articles/s41...
From @zgerharthines.bsky.social group identifying neuronal NK2R as a regulator of feeding/hunger & energy expenditure, and demonstrating the efficacy of a small molecule agonist in non-human primates for weight loss.
www.nature.com/articles/s41...
NK2R control of energy expenditure and feeding to treat metabolic diseases - Nature
In mouse and nonhuman primate models, treatment with selective, long-acting neurokinin 2 receptor agonists aids weight loss by suppressing appetite and increasing energy expenditure, as well as b...
www.nature.com
November 25, 2024 at 10:41 AM
First post! Didn't see this study on @bsky.app.
From @zgerharthines.bsky.social group identifying neuronal NK2R as a regulator of feeding/hunger & energy expenditure, and demonstrating the efficacy of a small molecule agonist in non-human primates for weight loss.
www.nature.com/articles/s41...
From @zgerharthines.bsky.social group identifying neuronal NK2R as a regulator of feeding/hunger & energy expenditure, and demonstrating the efficacy of a small molecule agonist in non-human primates for weight loss.
www.nature.com/articles/s41...
Reposted by Dominique Langin
🧬 New in @Nature: Our team found that fat cells keep a “memory” of their previous obese state even after weight loss, helping explain why maintaining weight loss is so challenging. Excited to share this work!!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Adipose tissue retains an epigenetic memory of obesity after weight loss - Nature
Stable epigenetic changes indicate the existence of an obesogenic memory in mouse adipocytes that primes cells for pathological responses in an obesogenic environment and potentially contributes to th...
www.nature.com
November 19, 2024 at 5:12 AM
🧬 New in @Nature: Our team found that fat cells keep a “memory” of their previous obese state even after weight loss, helping explain why maintaining weight loss is so challenging. Excited to share this work!!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A study from our lab @ I2MC Toulouse shows the importance of fat degradation in brown fat to generate heat. Fruitful collaboration with Prof. Carpentier at CHU Sherbrooke. Published in Cell Metab dlvr.it/TGGbFJ 🧪
https://dlvr.it/TGGbFJ🧪
November 22, 2024 at 9:37 PM
A study from our lab @ I2MC Toulouse shows the importance of fat degradation in brown fat to generate heat. Fruitful collaboration with Prof. Carpentier at CHU Sherbrooke. Published in Cell Metab dlvr.it/TGGbFJ 🧪
A new study led by Prof. Dominique Langin at I2MC Toulouse sheds light on the importance of fat degradation in brown fat to generate heat. Fruitful collaboration with Prof. Carpentier team at CHU Sherbrooke. Insight on how to burn calories published in Cell Metabolism.
dlvr.it/TGGbFJ
dlvr.it/TGGbFJ
Cold-induced thermogenesis requires neutral-lipase-mediated intracellular lipolysis in brown adipocytes
This study shows that intracellular lipolysis in brown adipose tissue (BAT) is essential
for cold-induced thermogenesis. By using a mouse model with ATGL/HSL deletion in BAT,
researchers revealed impa...
dlvr.it
November 20, 2024 at 6:04 AM
A new study led by Prof. Dominique Langin at I2MC Toulouse sheds light on the importance of fat degradation in brown fat to generate heat. Fruitful collaboration with Prof. Carpentier team at CHU Sherbrooke. Insight on how to burn calories published in Cell Metabolism.
dlvr.it/TGGbFJ
dlvr.it/TGGbFJ