chris cunningham
@doctor-cunningham.bsky.social
medicinal chemist, dachshund lover, better at playing fantasy sports than sports in real life
TLR4 is an important target in inflammation, and blocking it seems to have lots of valuable activities. From that paper, they showed a drop in neuropathic pain and drug reward, i.e., "feeling really good" from opioids and cocaine.
June 13, 2025 at 1:09 PM
TLR4 is an important target in inflammation, and blocking it seems to have lots of valuable activities. From that paper, they showed a drop in neuropathic pain and drug reward, i.e., "feeling really good" from opioids and cocaine.
Since I'm not seeing it show up - I hate Disqus, it has never worked well for me - here is a link to (+)-naloxone and (+)-naltrexone as TLR4 antagonists: pmc.ncbi.nlm.nih.gov/articles/PMC...
Pharmacological characterization of the opioid inactive isomers (+)‐naltrexone and (+)‐naloxone as antagonists of toll‐like receptor 4
The toll‐like receptor TLR4 is involved in neuropathic pain and in drug reward and reinforcement. The opioid inactive isomers (+)‐naltrexone and (+)‐naloxone act as TLR4 antagonists, reversing neuropa...
pmc.ncbi.nlm.nih.gov
June 13, 2025 at 1:09 PM
Since I'm not seeing it show up - I hate Disqus, it has never worked well for me - here is a link to (+)-naloxone and (+)-naltrexone as TLR4 antagonists: pmc.ncbi.nlm.nih.gov/articles/PMC...
I sat through some pretty dire games as a grad student at UMB between 2003-2008, and it was sweet that the tickets cost less than a Maryland craft beer...
May 18, 2025 at 2:44 PM
I sat through some pretty dire games as a grad student at UMB between 2003-2008, and it was sweet that the tickets cost less than a Maryland craft beer...
how does one "AI-proof an assignment"?
May 15, 2025 at 11:59 AM
how does one "AI-proof an assignment"?
That's what Allison says, and she travels to Glorioso's all the time. It's harrowing!
April 30, 2025 at 10:38 AM
That's what Allison says, and she travels to Glorioso's all the time. It's harrowing!
Man, I thought this was supposed to be the party of freedom of speech...how do I prove that I'm not part of some boycott?!
April 22, 2025 at 12:44 PM
Man, I thought this was supposed to be the party of freedom of speech...how do I prove that I'm not part of some boycott?!
Cyanobacteria targeting sigma...super cool! Those cyclic friends might cross the BBB!
February 12, 2025 at 11:55 PM
Cyanobacteria targeting sigma...super cool! Those cyclic friends might cross the BBB!
I thought so, so I included a comment about start-ups at the thread
February 8, 2025 at 3:24 PM
I thought so, so I included a comment about start-ups at the thread
My "like" isn't that I "like" this idea, just that I agree that what you say is the point!
February 8, 2025 at 3:23 PM
My "like" isn't that I "like" this idea, just that I agree that what you say is the point!
Oh yeah, one other thing: NIH, NSF, et al., also support start-up companies, small businesses with big ideas that rely on federal grants. Cuts like these may lead to cuts to their bottom lines, too.
February 8, 2025 at 2:03 PM
Oh yeah, one other thing: NIH, NSF, et al., also support start-up companies, small businesses with big ideas that rely on federal grants. Cuts like these may lead to cuts to their bottom lines, too.
This thread is not just a rant: contact your congresspeople. A resource is below. Tell them to support academic research and prevent HHS from unilaterally imposing strict overhead rates. www.congress.gov/members/find...
www.congress.gov
February 8, 2025 at 2:03 PM
This thread is not just a rant: contact your congresspeople. A resource is below. Tell them to support academic research and prevent HHS from unilaterally imposing strict overhead rates. www.congress.gov/members/find...
Do some institutes like Scripps and the Salk have high IDC rates? Sure. You kinda need that to attract Nobel laureates and build in expensive areas. You want to negotiate that down? Come to the table. Don't let a guy cosplaying as America's CEO screw us small fries.
February 8, 2025 at 2:03 PM
Do some institutes like Scripps and the Salk have high IDC rates? Sure. You kinda need that to attract Nobel laureates and build in expensive areas. You want to negotiate that down? Come to the table. Don't let a guy cosplaying as America's CEO screw us small fries.
That IDC rate also goes toward upkeep and maintenance on our physical lab space. The fume hoods in my lab are double the age of my students and could fail at any minute. Will I be able to upgrade them now? :SHRUG:
February 8, 2025 at 2:03 PM
That IDC rate also goes toward upkeep and maintenance on our physical lab space. The fume hoods in my lab are double the age of my students and could fail at any minute. Will I be able to upgrade them now? :SHRUG: