Denis Jabaudon
@djabaudon.bsky.social
Developmental neurobiologist, neurologist, & evo-devo aficionado. University of Geneva, Switzerland.
Interested in the mechanisms of neurogenesis, and how they might converge/differ across species, regions, and life epochs? Check this out, wonderful location and great science! Please RT
neuro-unige.ch/news/csf-mee...
neuro-unige.ch/news/csf-mee...
October 5, 2025 at 12:16 PM
Interested in the mechanisms of neurogenesis, and how they might converge/differ across species, regions, and life epochs? Check this out, wonderful location and great science! Please RT
neuro-unige.ch/news/csf-mee...
neuro-unige.ch/news/csf-mee...
"You cannot not communicate". Paul Watzlawick.
Highlights that all human interactions, even silence, are forms of communication and convey a message. Everything we do —or don't do — can be interpreted as communication by others. E.g. ghosting. There's no way out of being social.
Highlights that all human interactions, even silence, are forms of communication and convey a message. Everything we do —or don't do — can be interpreted as communication by others. E.g. ghosting. There's no way out of being social.
June 7, 2025 at 6:34 AM
"You cannot not communicate". Paul Watzlawick.
Highlights that all human interactions, even silence, are forms of communication and convey a message. Everything we do —or don't do — can be interpreted as communication by others. E.g. ghosting. There's no way out of being social.
Highlights that all human interactions, even silence, are forms of communication and convey a message. Everything we do —or don't do — can be interpreted as communication by others. E.g. ghosting. There's no way out of being social.
Hence, cellular clocks tick at different paces across brain regions due to distinct metabolic properties of progenitors. This work thus adds to research on metabolism setting cellular timing across species, by showing these differences regulate brain shape within species too!
May 5, 2025 at 4:52 PM
Hence, cellular clocks tick at different paces across brain regions due to distinct metabolic properties of progenitors. This work thus adds to research on metabolism setting cellular timing across species, by showing these differences regulate brain shape within species too!
Using in vivo gain- and loss- of function of FAM210B in the hindbrain and neocortex, respectively, we find that FAM210B elongates mitochondria and increases
lactate production, which promotes progenitor self-replicative divisions and, ultimately, a larger clonal size of their progeny.
lactate production, which promotes progenitor self-replicative divisions and, ultimately, a larger clonal size of their progeny.
May 5, 2025 at 4:52 PM
Using in vivo gain- and loss- of function of FAM210B in the hindbrain and neocortex, respectively, we find that FAM210B elongates mitochondria and increases
lactate production, which promotes progenitor self-replicative divisions and, ultimately, a larger clonal size of their progeny.
lactate production, which promotes progenitor self-replicative divisions and, ultimately, a larger clonal size of their progeny.
Using scRNA sequencing of all ventricular progenitors, we found genes with spatially and temporally restricted expression (baumannn.shinyapps.io/Ventriculome). Amongst these, the mitochondrial protein Fam210b was expressed where and when cell-cycle is the longest.
May 5, 2025 at 4:52 PM
Using scRNA sequencing of all ventricular progenitors, we found genes with spatially and temporally restricted expression (baumannn.shinyapps.io/Ventriculome). Amongst these, the mitochondrial protein Fam210b was expressed where and when cell-cycle is the longest.
When we examined regional cell-cycling behavior of progenitors, we found less consumptive divisions in cortical progenitors compared to hindbrain ones, resulting in a sustained availability of the progenitor pool in the cortex. Mitochondrial morphology was different across regions too!
May 5, 2025 at 4:52 PM
When we examined regional cell-cycling behavior of progenitors, we found less consumptive divisions in cortical progenitors compared to hindbrain ones, resulting in a sustained availability of the progenitor pool in the cortex. Mitochondrial morphology was different across regions too!
Using this atlas, we find that while both forebrain and hindbrain regions are born early, only in the forebrain – and particularly in the cortex – is there a prolonged time window of neurogenesis. Some regions thus show transient neurogenesis, while in others it is sustained.
May 5, 2025 at 4:52 PM
Using this atlas, we find that while both forebrain and hindbrain regions are born early, only in the forebrain – and particularly in the cortex – is there a prolonged time window of neurogenesis. Some regions thus show transient neurogenesis, while in others it is sustained.
As a first step to address this question, we built a spatio-temporal atlas of neuronal birth across brain structures, available at neurobirth.org (use your PC to navigate), building on Altman and Bayer’s seminal work on brain development (www.neurondevelopment.org).
May 5, 2025 at 4:52 PM
As a first step to address this question, we built a spatio-temporal atlas of neuronal birth across brain structures, available at neurobirth.org (use your PC to navigate), building on Altman and Bayer’s seminal work on brain development (www.neurondevelopment.org).
Why does the forebrain expand dramatically while other neural regions grow less? Our new publication reveals progenitor metabolism critically shapes region-specific brain growth. Thread below. authors.elsevier.com/a/1k-udL7PXu...
May 5, 2025 at 4:52 PM
Why does the forebrain expand dramatically while other neural regions grow less? Our new publication reveals progenitor metabolism critically shapes region-specific brain growth. Thread below. authors.elsevier.com/a/1k-udL7PXu...
#Standupforscience event today at Campus Biotech in Geneva. In solidarity for our colleagues in the US and in support of universal values of science: transparency, evidence, cooperation, and intellectual honesty.
March 7, 2025 at 3:57 PM
#Standupforscience event today at Campus Biotech in Geneva. In solidarity for our colleagues in the US and in support of universal values of science: transparency, evidence, cooperation, and intellectual honesty.
Open positions in neuroimmunology in Paris, check it out!
March 5, 2025 at 4:34 PM
Open positions in neuroimmunology in Paris, check it out!
Interesting study on cell-type-specific aging using single-nuclei transcriptomics in the human neocortex. Not clear to me based on this graph that pace of aging is striking different across cell types.
doi.org/10.1101/2025...
see also
https://doi.org:10.1038/s41593-024-01742-z
doi.org/10.1101/2025...
see also
https://doi.org:10.1038/s41593-024-01742-z
March 3, 2025 at 6:24 AM
Interesting study on cell-type-specific aging using single-nuclei transcriptomics in the human neocortex. Not clear to me based on this graph that pace of aging is striking different across cell types.
doi.org/10.1101/2025...
see also
https://doi.org:10.1038/s41593-024-01742-z
doi.org/10.1101/2025...
see also
https://doi.org:10.1038/s41593-024-01742-z
A bit of a spooky title, but nice ressource for longitudinal imaging of brain connectivity throughout life.
Functional Hierarchy of the Human Neocortex from Cradle to Grave doi.org/10.1101/2024...
Functional Hierarchy of the Human Neocortex from Cradle to Grave doi.org/10.1101/2024...
March 3, 2025 at 6:09 AM
A bit of a spooky title, but nice ressource for longitudinal imaging of brain connectivity throughout life.
Functional Hierarchy of the Human Neocortex from Cradle to Grave doi.org/10.1101/2024...
Functional Hierarchy of the Human Neocortex from Cradle to Grave doi.org/10.1101/2024...
Long-term in vivo imaging of single neurons in the developing mouse brain from early postnatal days on. A game-changer in figuring out developmental trajectories. From the Cossart lab.
doi.org/10.1101/2025...
doi.org/10.1101/2025...
March 3, 2025 at 5:51 AM
Long-term in vivo imaging of single neurons in the developing mouse brain from early postnatal days on. A game-changer in figuring out developmental trajectories. From the Cossart lab.
doi.org/10.1101/2025...
doi.org/10.1101/2025...
There are no ASD or ALS genes. Just like there are no ASD or ALS patients.
There are genes associated with these diseases, and people with them.
It's beyond semantics; it's about pleiotropy (genes) & individuality (patients). Denying complexity doesn't make a problem simpler to solve (tell POTUS).
There are genes associated with these diseases, and people with them.
It's beyond semantics; it's about pleiotropy (genes) & individuality (patients). Denying complexity doesn't make a problem simpler to solve (tell POTUS).
February 26, 2025 at 4:33 AM
There are no ASD or ALS genes. Just like there are no ASD or ALS patients.
There are genes associated with these diseases, and people with them.
It's beyond semantics; it's about pleiotropy (genes) & individuality (patients). Denying complexity doesn't make a problem simpler to solve (tell POTUS).
There are genes associated with these diseases, and people with them.
It's beyond semantics; it's about pleiotropy (genes) & individuality (patients). Denying complexity doesn't make a problem simpler to solve (tell POTUS).
The Zona Incerta is really what its name suggests it is. Contains two distinct GBAergic subtypes of neurons involved in seemingly unrelated behaviors: self-grooming for one, and sleep-to-wake transition for the other.
www.biorxiv.org/content/10.1...
PS: named by swiss anatomist August Forel 🫕🇨🇭
www.biorxiv.org/content/10.1...
PS: named by swiss anatomist August Forel 🫕🇨🇭
February 14, 2025 at 6:11 AM
The Zona Incerta is really what its name suggests it is. Contains two distinct GBAergic subtypes of neurons involved in seemingly unrelated behaviors: self-grooming for one, and sleep-to-wake transition for the other.
www.biorxiv.org/content/10.1...
PS: named by swiss anatomist August Forel 🫕🇨🇭
www.biorxiv.org/content/10.1...
PS: named by swiss anatomist August Forel 🫕🇨🇭
Interesting: following hemispherotomy – this is typically performed for severe intractable epilepsies, where one hemisphere is fully disconnected but left in place – there remains "islands of awareness" although most activity is sleep-like.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
February 13, 2025 at 7:41 AM
Interesting: following hemispherotomy – this is typically performed for severe intractable epilepsies, where one hemisphere is fully disconnected but left in place – there remains "islands of awareness" although most activity is sleep-like.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
This is cool: three blind raters were asked to guess, based solely on anonymized dream reports, which audiobook someone had listened to before experiencing a dream.
Turns out they were quite good at it. Beyond the researchers' own wildest dreams I guess...
www.biorxiv.org/content/10.1...
Turns out they were quite good at it. Beyond the researchers' own wildest dreams I guess...
www.biorxiv.org/content/10.1...
February 13, 2025 at 7:35 AM
This is cool: three blind raters were asked to guess, based solely on anonymized dream reports, which audiobook someone had listened to before experiencing a dream.
Turns out they were quite good at it. Beyond the researchers' own wildest dreams I guess...
www.biorxiv.org/content/10.1...
Turns out they were quite good at it. Beyond the researchers' own wildest dreams I guess...
www.biorxiv.org/content/10.1...
"Eye blinks synchronize with musical beats during music listening"
www.biorxiv.org/content/10.1...
Damn, can't help but think about what the DOGE would think of this...
Interesting effect though; could be useful for group pics.
www.biorxiv.org/content/10.1...
Damn, can't help but think about what the DOGE would think of this...
Interesting effect though; could be useful for group pics.
February 13, 2025 at 7:23 AM
"Eye blinks synchronize with musical beats during music listening"
www.biorxiv.org/content/10.1...
Damn, can't help but think about what the DOGE would think of this...
Interesting effect though; could be useful for group pics.
www.biorxiv.org/content/10.1...
Damn, can't help but think about what the DOGE would think of this...
Interesting effect though; could be useful for group pics.
Surmounting the ceiling effect: exposing expert pianists to fast and complex finger movements that cannot be performed voluntarily allows them to then improve. Transferable from one hand to the other.
I think that's what ChatGPT does to us too.
www.science.org/doi/10.1126/...
I think that's what ChatGPT does to us too.
www.science.org/doi/10.1126/...
February 11, 2025 at 4:33 PM
Surmounting the ceiling effect: exposing expert pianists to fast and complex finger movements that cannot be performed voluntarily allows them to then improve. Transferable from one hand to the other.
I think that's what ChatGPT does to us too.
www.science.org/doi/10.1126/...
I think that's what ChatGPT does to us too.
www.science.org/doi/10.1126/...
Why do people still use the term "Malformations of Cortical Development" (MCD)?
A malformation is a developmental process, there is no need for redundancy; development cannot be malformed.
"Cortical Malformations" (CM) alone does the job.
Just like the gulf of Mexico is the gulf of Mexico.
A malformation is a developmental process, there is no need for redundancy; development cannot be malformed.
"Cortical Malformations" (CM) alone does the job.
Just like the gulf of Mexico is the gulf of Mexico.
February 11, 2025 at 7:49 AM
Why do people still use the term "Malformations of Cortical Development" (MCD)?
A malformation is a developmental process, there is no need for redundancy; development cannot be malformed.
"Cortical Malformations" (CM) alone does the job.
Just like the gulf of Mexico is the gulf of Mexico.
A malformation is a developmental process, there is no need for redundancy; development cannot be malformed.
"Cortical Malformations" (CM) alone does the job.
Just like the gulf of Mexico is the gulf of Mexico.
🧠Job Opening!🧠
We are opening 2️⃣! positions
– bioinformatics / molecular biology –
in a project studying how temporal patterns set up connectivity in human brain tissue.
@institutimagine.bsky.social.
Full details below, contact me for details if interested.
And please retweet (re-bluesky?)!
We are opening 2️⃣! positions
– bioinformatics / molecular biology –
in a project studying how temporal patterns set up connectivity in human brain tissue.
@institutimagine.bsky.social.
Full details below, contact me for details if interested.
And please retweet (re-bluesky?)!
February 2, 2025 at 9:27 AM
🧠Job Opening!🧠
We are opening 2️⃣! positions
– bioinformatics / molecular biology –
in a project studying how temporal patterns set up connectivity in human brain tissue.
@institutimagine.bsky.social.
Full details below, contact me for details if interested.
And please retweet (re-bluesky?)!
We are opening 2️⃣! positions
– bioinformatics / molecular biology –
in a project studying how temporal patterns set up connectivity in human brain tissue.
@institutimagine.bsky.social.
Full details below, contact me for details if interested.
And please retweet (re-bluesky?)!
What is the probability of drinking the same molecule of H20 twice in a lifetime?
Asked Claude.ai to do the math; checked it roughly and turns out it's highly likely.
Asked Claude.ai to do the math; checked it roughly and turns out it's highly likely.
January 27, 2025 at 1:15 PM
What is the probability of drinking the same molecule of H20 twice in a lifetime?
Asked Claude.ai to do the math; checked it roughly and turns out it's highly likely.
Asked Claude.ai to do the math; checked it roughly and turns out it's highly likely.
Ah cool, thanks! Slight decrease in frontal cortex but not elsewhere it seems.
January 21, 2025 at 2:13 PM
Ah cool, thanks! Slight decrease in frontal cortex but not elsewhere it seems.
How strong is the evidence that neuron numbers decrease with age in humans? Had a hard time finding something reliable.
January 21, 2025 at 10:00 AM
How strong is the evidence that neuron numbers decrease with age in humans? Had a hard time finding something reliable.