Dominik Hrebik
@dhrebik.bsky.social
Postdoc @JohnBriggsGroup @MaxPlanck Institute of Biochemistry in Martinsried
| PhD from PlevkaLab | #StructuralBiology of #Viruses #HIV | #CryoEM | #Memes
Twitter/X: @F4ustus
| PhD from PlevkaLab | #StructuralBiology of #Viruses #HIV | #CryoEM | #Memes
Twitter/X: @F4ustus
It was, however, only in 2021 when my colleague Kun Qu obtained the first in virus structure of the matrix protein (K Qu, Science 2021). It revealed that the matrix undergoes structural rearrangement and binds a ligand upon maturation, which was predicted to be a PIP2 lipid. 3/x
November 12, 2024 at 9:04 PM
It was, however, only in 2021 when my colleague Kun Qu obtained the first in virus structure of the matrix protein (K Qu, Science 2021). It revealed that the matrix undergoes structural rearrangement and binds a ligand upon maturation, which was predicted to be a PIP2 lipid. 3/x
Our new preprint from Briggs lab is out! We solved the in-virus #cryoEM structure of the HIV matrix protein by SPA. The structure led us to a discovery resolving a long mystery in HIV biology – a peptide SP2 triggers the maturation of the HIV matrix domain. A 🧵 1/x
Paper: tinyurl.com/c7szhtfa
Paper: tinyurl.com/c7szhtfa
November 12, 2024 at 9:04 PM
Our new preprint from Briggs lab is out! We solved the in-virus #cryoEM structure of the HIV matrix protein by SPA. The structure led us to a discovery resolving a long mystery in HIV biology – a peptide SP2 triggers the maturation of the HIV matrix domain. A 🧵 1/x
Paper: tinyurl.com/c7szhtfa
Paper: tinyurl.com/c7szhtfa