5/5 In a similar way, Rosi drives the blossom of preadipocytes even in unhealthy environments (obesity)! Cover art by Demin Lu – MolGraphics (www.molgraphics.com)

4/5 Inspired also by the poem from Carlos Drummond de Andrade
“A flower rose from the street!
[…] breaks the asphalt […]
I assure you that a flower rose
Its color is unnoticed
Its petals don’t open
Its name is not in the books […] but it is truly a flower!”

3/5 From this orchestrated bloom, vibrant, mature petals - fat cells in their fullest form - unveil themselves like a masterpiece of adipogenesis.

2/5 These blossoms emerge as a pool of heterogeneous progenitor leaves and preadipocyte buds. Bathed in the essence of Rosiglitazone, the immature petals slowly unfurl, by the crescendo of ribosomal protein expression within the flower’s nuclear heart.

Congratulations Mirian @desiqueiramk.bsky.social , the Villanueva and Yang labs at UCLA! Happy to have contributed to such beautiful work highlighting the role of mRNA translation in adipocyte biology.

5/5: A big thank you to our funding sources for making this research possible @americanheart.bsky.social #UCLA #UCLAIBP - your support is invaluable in advancing our understanding of adipose biology and metabolic health!

4/5: Finally, we show how rosiglitazone treatment enhances translation in adipose progenitors, promoting adipogenesis. Blocking this effect via eIF4A inhibition reverses the benefits, highlighting translation remodeling as a key to adipose tissue health in obesity.

3/5: We discovered that PPARγ-driven ribosomal remodeling enhances adipocyte progenitor and preadipocyte differentiation potential. This effect is directly linked to PPARγ binding to ribosomal genes and is crucial for adipogenesis in obesity.

2/5: Using single-cell RNA sequencing, we mapped how rosiglitazone (a PPARγ agonist) reshapes transcriptional profiles in adipose tissue, shifting obese states to lean-like ones. Key changes include decreased inflammation & increased lipid metabolism and ribosomal activity.

1/5: Adipose tissue is central to energy balance and metabolic health, but obesity disrupts its adaptability. Our latest study in #CellReports explores how translation in adipose progenitors is regulated, revealing key insights into obesity's impact.