@ped-neph.bsky.social

💡 Key takeaway:

In children on chronic, high-dose or combination immunosuppression, consider BK virus in the differential for unexplained renal dysfunction.

Early recognition and careful adjustment of therapy can help preserve kidney function.

👧 11-year-old with a rare autoinflammatory condition on JAK inhibitor + biologic therapy.

She developed kidney impairment and was found to have biopsy-proven BK virus nephropathy in her native kidneys.

🧠 BK virus is usually known for causing kidney injury in transplant recipients.

But this case shows it can also affect non-transplanted, immunosuppressed children

Thanks to @researchireland.ie for the support!

Wonderful, as always, to work with @danoreillyicu.bsky.social and @mijkboyle.bsky.social

Does the MAHA stand for the microangiopathic hemolytic anemia they’ll get from the HUS 🙈

A pleasure to work with @mijkboyle.bsky.social & @danoreillyicu.bsky.social

Thanks as always, to @researchireland.bsky.social for their support!

We had a look at doing some binary regression, but results wouldn’t have much validity given the small numbers. Hoping to explore it in a larger, more recent cohort and will plan to publish soon.