I still get chills

Meet Mike
*30+ years severe depression
*first hospitalized @ 13y
*20 meds
*3 rounds of ECT
*2 near-fatal suicide attempts

Mike felt joy for the first time in decades after we turned on his new brain pacemaker or PACE

see videos, read paper, follow thread
doi.org/10.31234/osf...

✨ Announcing a new glutamate indicator - iGluSnFR4! ✨

Launched as a pair, iGLuSnFR4s and iGluSnFR4f have high-sensitivity and fast activation/deactivation for recording synapses.

More on the indicators and what they are already revealing: www.biorxiv.org/content/10.1...

🧠📈

Excited to share that our paper is now published in Nature! In this study, we uncovered a grid-cell-based circuit in medial entorhinal cortex that probes the surrounding environment with theta-paced, sweeping spatial representations 🧵
www.nature.com/articles/s41...

I had so much fun ushering in the Year of the Snake with everyone at the @alleninstitute.bsky.social. Thank you to Mak Fai Lion Dance putting on such a great show.

Wishing you all a year of health and prosperity!
#LunarNewYear #YearOfTheSnake

New paper from the lab: feedback from piriform cortex to the olfactory bulb carries identity and reward contingency signals in a multimodal (odor and sound) rule-reversal task. Feedback is re-formatted within seconds and reflects changes in the perceived rules of engagement.
doi.org/10.1038/s414...