Elvira De Leonibus
@deleonibuslab.bsky.social
In love with my Kids and Sanfilippo kids, neuroscience, dopamine, memory
⚖️ Takeaway?
The good and the bad of dopamine all depend on the dose — and the circuit engaged.
🧠 A special thank to Maria De Risi, brilliant, talented, and extraordinarily productive scientist and to Diletta Cavezza #Giulia Torromino, Anita Capalbo Xabier Bujanda Cundin
The good and the bad of dopamine all depend on the dose — and the circuit engaged.
🧠 A special thank to Maria De Risi, brilliant, talented, and extraordinarily productive scientist and to Diletta Cavezza #Giulia Torromino, Anita Capalbo Xabier Bujanda Cundin
April 3, 2025 at 9:35 AM
⚖️ Takeaway?
The good and the bad of dopamine all depend on the dose — and the circuit engaged.
🧠 A special thank to Maria De Risi, brilliant, talented, and extraordinarily productive scientist and to Diletta Cavezza #Giulia Torromino, Anita Capalbo Xabier Bujanda Cundin
The good and the bad of dopamine all depend on the dose — and the circuit engaged.
🧠 A special thank to Maria De Risi, brilliant, talented, and extraordinarily productive scientist and to Diletta Cavezza #Giulia Torromino, Anita Capalbo Xabier Bujanda Cundin
🧪 Our #phosphoproteomic data reveal that low vs. high doses of D1 agonist trigger completely different signaling profiles.
It’s as if we were administering two entirely different drugs — astonishing!
It’s as if we were administering two entirely different drugs — astonishing!
April 3, 2025 at 9:35 AM
🧪 Our #phosphoproteomic data reveal that low vs. high doses of D1 agonist trigger completely different signaling profiles.
It’s as if we were administering two entirely different drugs — astonishing!
It’s as if we were administering two entirely different drugs — astonishing!
🧬 #PKA has long been considered essential for hippocampus-dependent long-term memory, but deleterious for #WM.
We demonstrate that PKA activation in the striatum is beneficial for working memory capacity. This calls for targeted, region-specific PKA modulators — intelligent PKA agents.
We demonstrate that PKA activation in the striatum is beneficial for working memory capacity. This calls for targeted, region-specific PKA modulators — intelligent PKA agents.
April 3, 2025 at 9:35 AM
🧠💡 Why does this matter?
✅ We confirm that low doses improve memory in a schizophrenia mouse model, using the same dose range previously applied by #PatriciaGoldman-Rakic in monkeys (unlike the much higher doses in recent rodent studies).
✅ We confirm that low doses improve memory in a schizophrenia mouse model, using the same dose range previously applied by #PatriciaGoldman-Rakic in monkeys (unlike the much higher doses in recent rodent studies).
April 3, 2025 at 9:35 AM
🧠💡 Why does this matter?
✅ We confirm that low doses improve memory in a schizophrenia mouse model, using the same dose range previously applied by #PatriciaGoldman-Rakic in monkeys (unlike the much higher doses in recent rodent studies).
✅ We confirm that low doses improve memory in a schizophrenia mouse model, using the same dose range previously applied by #PatriciaGoldman-Rakic in monkeys (unlike the much higher doses in recent rodent studies).
✔️ High-dose recruits PKA in the cortex — again, not novel — but:
Cortical PKA activation recruits parvalbumin interneurons in the #striatum, shutting down the striatum, thus impairing memory.
Thus: a fronto-striatal circuit mechanism for the dose-dependent effects of DA drugs on memory.
Cortical PKA activation recruits parvalbumin interneurons in the #striatum, shutting down the striatum, thus impairing memory.
Thus: a fronto-striatal circuit mechanism for the dose-dependent effects of DA drugs on memory.
April 3, 2025 at 9:35 AM
✔️ High-dose recruits PKA in the cortex — again, not novel — but:
Cortical PKA activation recruits parvalbumin interneurons in the #striatum, shutting down the striatum, thus impairing memory.
Thus: a fronto-striatal circuit mechanism for the dose-dependent effects of DA drugs on memory.
Cortical PKA activation recruits parvalbumin interneurons in the #striatum, shutting down the striatum, thus impairing memory.
Thus: a fronto-striatal circuit mechanism for the dose-dependent effects of DA drugs on memory.
This inverted-U dose-response curve is well-known in the literature — nothing new here.
🔍 So, what’s new?
✔️ Low-dose D1 stimulation expands MC via #PKA activation in the striatum.
We show that striatal PKA activation is both necessary and sufficient to enhance memory capacity.
🔍 So, what’s new?
✔️ Low-dose D1 stimulation expands MC via #PKA activation in the striatum.
We show that striatal PKA activation is both necessary and sufficient to enhance memory capacity.
April 3, 2025 at 9:35 AM
This inverted-U dose-response curve is well-known in the literature — nothing new here.
🔍 So, what’s new?
✔️ Low-dose D1 stimulation expands MC via #PKA activation in the striatum.
We show that striatal PKA activation is both necessary and sufficient to enhance memory capacity.
🔍 So, what’s new?
✔️ Low-dose D1 stimulation expands MC via #PKA activation in the striatum.
We show that striatal PKA activation is both necessary and sufficient to enhance memory capacity.
Grazie Francesco ❤️
February 2, 2025 at 9:58 PM
Grazie Francesco ❤️
Hi Camille, we use rat 226 017. You can send an email to diletta.cavezza@ibbc.cnr.it for details
January 15, 2025 at 8:51 PM
Hi Camille, we use rat 226 017. You can send an email to diletta.cavezza@ibbc.cnr.it for details
Super! Congrats!
January 15, 2025 at 8:48 PM
Super! Congrats!
Mhh we use it, without problems. What is the problem?
January 14, 2025 at 8:58 AM
Mhh we use it, without problems. What is the problem?
Relevant to this www.pnas.org/doi/10.1073/...
The costs of competition in distributing scarce research funds | PNAS
Research funding systems fundamentally influence how science operates. This paper
aims to analyze the allocation of competitive research funding fr...
www.pnas.org
January 5, 2025 at 10:27 AM
Relevant to this www.pnas.org/doi/10.1073/...