César de la Fuente
@delafuentelab.bsky.social
Presidential Associate Professor @upenn.edu - using AI to reimagine antibiotic discovery and peptide design. Previously @MIT, @UBC
🔗 https://delafuentelab.seas.upenn.edu
🔗 https://delafuentelab.seas.upenn.edu
Huge thanks to @nikomccarty.bsky.social and the @asimovpress.bsky.social Podcast for the incredible gift—a book encoded in DNA! 🧬📖
A beautiful fusion of science, art, and storytelling.
A beautiful fusion of science, art, and storytelling.
November 10, 2025 at 9:32 AM
Huge thanks to @nikomccarty.bsky.social and the @asimovpress.bsky.social Podcast for the incredible gift—a book encoded in DNA! 🧬📖
A beautiful fusion of science, art, and storytelling.
A beautiful fusion of science, art, and storytelling.
🎥 Proud to share my @upenn.edu Penn Today video, “Uncovering New Antibiotics with AI.” See how AI is helping us find tomorrow’s antibiotics—today. Watch: penntoday.upenn.edu/news/uncover...
Uncovering new antibiotics with AI | Penn Today
César de la Fuente leverages machine learning to accelerate the discovery of lifesaving drugs and help reduce antibiotic resistance, a rising global health problem.
penntoday.upenn.edu
November 6, 2025 at 10:54 AM
🎥 Proud to share my @upenn.edu Penn Today video, “Uncovering New Antibiotics with AI.” See how AI is helping us find tomorrow’s antibiotics—today. Watch: penntoday.upenn.edu/news/uncover...
En mi charla de Frontiers in Genomics de UNAM MX exploro cómo la IA puede transformar el descubrimiento de antibióticos: de la minería de datos a la biología digital. 💡🔬 ¡No te la pierdas!
👉 www.youtube.com/watch?app=de...
👉 www.youtube.com/watch?app=de...
Frontiers in Genomics - César de la Fuente - 23 septiembre 2025 9am
YouTube video by LCG UNAM
www.youtube.com
November 5, 2025 at 11:46 AM
En mi charla de Frontiers in Genomics de UNAM MX exploro cómo la IA puede transformar el descubrimiento de antibióticos: de la minería de datos a la biología digital. 💡🔬 ¡No te la pierdas!
👉 www.youtube.com/watch?app=de...
👉 www.youtube.com/watch?app=de...
Science runs on curiosity… and cookies. 🍪🧪 Thanks The Scientist for spotlighting our “Cookie Wednesday,” a sweet way to fuel cross-disciplinary creativity.
www.the-scientist.com/scientists-s...
www.the-scientist.com/scientists-s...
Scientists Spill Their Quirky Lab Traditions and Superstitions
From lucky tokens that keep instruments running smoothly to a weekly cookie break, scientists told us about their favorite lab customs and beliefs.
www.the-scientist.com
November 3, 2025 at 12:08 PM
Science runs on curiosity… and cookies. 🍪🧪 Thanks The Scientist for spotlighting our “Cookie Wednesday,” a sweet way to fuel cross-disciplinary creativity.
www.the-scientist.com/scientists-s...
www.the-scientist.com/scientists-s...
My friend #EltonBrand @sixersnba.bsky.social and I at my lab's Halloween party talking about the future of AI and Sports. What are your thoughts? Do you think #RudyFernandez and #SergeiIbaka would approve of our costumes?😉 Wishing everyone a Happy Halloween! 🎃
October 31, 2025 at 12:14 PM
My friend #EltonBrand @sixersnba.bsky.social and I at my lab's Halloween party talking about the future of AI and Sports. What are your thoughts? Do you think #RudyFernandez and #SergeiIbaka would approve of our costumes?😉 Wishing everyone a Happy Halloween! 🎃
Big day at @upenn.edu ! Honored to host my friend Elton Brand from @sixersnba.bsky.social for a deep dive into how we’re using AI to fight antimicrobial resistance. Thanks for the sharp questions and team spirit, Elton! 🧪🏀
October 30, 2025 at 2:08 PM
Big day at @upenn.edu ! Honored to host my friend Elton Brand from @sixersnba.bsky.social for a deep dive into how we’re using AI to fight antimicrobial resistance. Thanks for the sharp questions and team spirit, Elton! 🧪🏀
It was an honor to participate in the third course organized by @mobilise.bsky.social @i3suporto.bsky.social, sharing experiences with incredible people. A privilege to learn, share, and connect with such an amazing group.
October 30, 2025 at 10:35 AM
It was an honor to participate in the third course organized by @mobilise.bsky.social @i3suporto.bsky.social, sharing experiences with incredible people. A privilege to learn, share, and connect with such an amazing group.
Check out our @natbiotech.nature.com @natureportfolio.nature.com piece with Yumeng Zhang + Jiangning Song on @genentech.bsky.social's deep learning approach to accelerate antibiotic discovery. Congrats to Gabriele Scalia, Tommaso Biancalani, Man-Wah Tan, Aviv Regev, @yoshuabengio.bsky.social et al!
Deep learning speeds the search for new antibiotic scaffolds #NBTNV - @delafuentelab.bsky.social go.nature.com/47fxSSv
Deep learning speeds the search for new antibiotic scaffolds - Nature Biotechnology
A deep learning model trained on experimental data from high-throughput screening identifies structurally novel antimicrobial compounds.
go.nature.com
October 29, 2025 at 4:56 PM
Check out our @natbiotech.nature.com @natureportfolio.nature.com piece with Yumeng Zhang + Jiangning Song on @genentech.bsky.social's deep learning approach to accelerate antibiotic discovery. Congrats to Gabriele Scalia, Tommaso Biancalani, Man-Wah Tan, Aviv Regev, @yoshuabengio.bsky.social et al!
Reposted by César de la Fuente
Feed: "Nature Biotechnology"
By: Tommaso Biancalani
By: Tommaso Biancalani
Deep-learning-based virtual screening of antibacterial compounds
Antibacterial compounds are discovered by combining phenotypic screening with deep learning.
www.nature.com
October 24, 2025 at 8:37 PM
Feed: "Nature Biotechnology"
By: Tommaso Biancalani
By: Tommaso Biancalani
Reposted by César de la Fuente
Deep learning reveals antibiotics in the archaeal proteome 🏺🧪
Marcelo D. T. Torres, Cesar de la Fuente-Nunez @delafuentelab.bsky.social et al
www.nature.com/articles/s41...
Findings highlight the potential of archaea as a resource for developing next-generation antibiotics.
Marcelo D. T. Torres, Cesar de la Fuente-Nunez @delafuentelab.bsky.social et al
www.nature.com/articles/s41...
Findings highlight the potential of archaea as a resource for developing next-generation antibiotics.
October 29, 2025 at 3:31 PM
Deep learning reveals antibiotics in the archaeal proteome 🏺🧪
Marcelo D. T. Torres, Cesar de la Fuente-Nunez @delafuentelab.bsky.social et al
www.nature.com/articles/s41...
Findings highlight the potential of archaea as a resource for developing next-generation antibiotics.
Marcelo D. T. Torres, Cesar de la Fuente-Nunez @delafuentelab.bsky.social et al
www.nature.com/articles/s41...
Findings highlight the potential of archaea as a resource for developing next-generation antibiotics.
Reposted by César de la Fuente
Feed: "Nature Biotechnology"
By: Cesar de la Fuente-Nunez
By: Cesar de la Fuente-Nunez
Deep learning speeds the search for new antibiotic scaffolds
A deep learning model trained on experimental data from high-throughput screening identifies structurally novel antimicrobial compounds.
www.nature.com
October 24, 2025 at 8:36 PM
Feed: "Nature Biotechnology"
By: Cesar de la Fuente-Nunez
By: Cesar de la Fuente-Nunez
Reposted by César de la Fuente
Penn's César de la Fuente joined Science Friday to discuss how his lab is using #AI to uncover new antibiotics hidden in ancient microorganisms—potentially offering new solutions to the global antibiotic resistance crisis. 🎧 Listen: https://www.sciencefriday.com/segments/nobel-prize-archaea/
An Off-The-Grid Nobel Win, And Antibiotics In Ancient Microbes
When the Nobel committee called, Fred Ramsdell did not pick up. Plus, searching ancient archaea for solutions to modern antibiotic resistance.
www.sciencefriday.com
October 24, 2025 at 3:55 PM
Penn's César de la Fuente joined Science Friday to discuss how his lab is using #AI to uncover new antibiotics hidden in ancient microorganisms—potentially offering new solutions to the global antibiotic resistance crisis. 🎧 Listen: https://www.sciencefriday.com/segments/nobel-prize-archaea/
1/5 Today we are introducing the Key-Cutting Machine (KCM) for protein and peptide design. Like cutting a key to fit a lock, KCM sculpts sequences to match a target backbone—on a single GPU. No retraining. No clusters. 🧬🔑
October 23, 2025 at 7:50 AM
1/5 Today we are introducing the Key-Cutting Machine (KCM) for protein and peptide design. Like cutting a key to fit a lock, KCM sculpts sequences to match a target backbone—on a single GPU. No retraining. No clusters. 🧬🔑
Reposted by César de la Fuente
La ULE propone el Honoris Causa al científico César de la Fuente y al ingeniero Sergio Boixo - www.heraldodeleon.es/articulo/uni...
La ULE propone el Honoris Causa al científico César de la Fuente y al ingeniero Sergio Boixo
El Consejo de Gobierno reconoce “la brillante trayectoria y el prestigio de ambos investigadores” y elevará la propuesta al Claustro de Doctores para su aprobación definitiva
www.heraldodeleon.es
October 22, 2025 at 11:08 AM
La ULE propone el Honoris Causa al científico César de la Fuente y al ingeniero Sergio Boixo - www.heraldodeleon.es/articulo/uni...
Grateful to @scifri.bsky.social for inviting me to share our latest work using AI to identify new antibiotics in archaea by digitally mining its genetic code. Huge thanks to @heyira.bsky.social for a wonderful conversation!
Bioengineer César de la Fuente looks for solutions to the antibiotic resistance crisis in unexpected places, including within the world of ancient archaea: buff.ly/zHluktd
October 22, 2025 at 3:10 PM
Grateful to @scifri.bsky.social for inviting me to share our latest work using AI to identify new antibiotics in archaea by digitally mining its genetic code. Huge thanks to @heyira.bsky.social for a wonderful conversation!
🧬 Today we introduce Key-Cutting Machine (KCM)—an AI tool that designs proteins like cutting a key to fit a lock.
Runs on 1 GPU. No retraining. No clusters.
Precise, accessible, and tested in vivo.
Now in @natmachintell.nature.com 🧠🔑
@natureportfolio.nature.com
www.nature.com/articles/s42...
Runs on 1 GPU. No retraining. No clusters.
Precise, accessible, and tested in vivo.
Now in @natmachintell.nature.com 🧠🔑
@natureportfolio.nature.com
www.nature.com/articles/s42...
Tailored structured peptide design with a key-cutting machine approach - Nature Machine Intelligence
Powerful generative AI models for designing biological macromolecules are being developed, with applications in medicine, biotechnology and materials science, but these models are expensive to train a...
www.nature.com
October 21, 2025 at 9:06 AM
🧬 Today we introduce Key-Cutting Machine (KCM)—an AI tool that designs proteins like cutting a key to fit a lock.
Runs on 1 GPU. No retraining. No clusters.
Precise, accessible, and tested in vivo.
Now in @natmachintell.nature.com 🧠🔑
@natureportfolio.nature.com
www.nature.com/articles/s42...
Runs on 1 GPU. No retraining. No clusters.
Precise, accessible, and tested in vivo.
Now in @natmachintell.nature.com 🧠🔑
@natureportfolio.nature.com
www.nature.com/articles/s42...
Thrilled to be part of this paper in npjAMR @natureportfolio with William J. Waldock, Hannah Thould, Leonid Chindelevitch, Nicholas J. Croucher, James J. Collins, Hutan Ashrafian & Ara Darzi! We tackle AMR globally and explore AI-driven solutions. www.nature.com/articles/s44...
Mitigating antimicrobial resistance by innovative solutions in AI (MARISA): a modified James Lind Alliance analysis - npj Antimicrobials and Resistance
npj Antimicrobials and Resistance - Mitigating antimicrobial resistance by innovative solutions in AI (MARISA): a modified James Lind Alliance analysis
www.nature.com
October 17, 2025 at 9:34 AM
Thrilled to be part of this paper in npjAMR @natureportfolio with William J. Waldock, Hannah Thould, Leonid Chindelevitch, Nicholas J. Croucher, James J. Collins, Hutan Ashrafian & Ara Darzi! We tackle AMR globally and explore AI-driven solutions. www.nature.com/articles/s44...
Reposted by César de la Fuente
Antibiotic resistance kills millions, but @delafuentelab.bsky.social's lab is fighting back. By pairing AI with human insight, researchers are uncovering hidden antimicrobial peptides across the tree of life with a 93% success rate against deadly pathogens.
ow.ly/u1Nl50XcRJW
ow.ly/u1Nl50XcRJW
Training AI to uncover novel antimicrobials
Antibiotic resistance kills millions, but César de la Fuente’s lab is fighting back. By pairing AI with human insight, researchers are uncovering hidden antimicrobial peptides across the tree of life ...
ow.ly
October 17, 2025 at 4:46 AM
Antibiotic resistance kills millions, but @delafuentelab.bsky.social's lab is fighting back. By pairing AI with human insight, researchers are uncovering hidden antimicrobial peptides across the tree of life with a 93% success rate against deadly pathogens.
ow.ly/u1Nl50XcRJW
ow.ly/u1Nl50XcRJW
AI could reshape infectious disease control end-to-end—from faster outbreak detection to smarter diagnostics—but progress is constrained by data. My
@thelancetinfdis.bsky.social @thelancet.com
article lays out how to break the bottleneck responsibly.
www.thelancet.com/journals/lan...
@thelancetinfdis.bsky.social @thelancet.com
article lays out how to break the bottleneck responsibly.
www.thelancet.com/journals/lan...
October 15, 2025 at 3:12 PM
AI could reshape infectious disease control end-to-end—from faster outbreak detection to smarter diagnostics—but progress is constrained by data. My
@thelancetinfdis.bsky.social @thelancet.com
article lays out how to break the bottleneck responsibly.
www.thelancet.com/journals/lan...
@thelancetinfdis.bsky.social @thelancet.com
article lays out how to break the bottleneck responsibly.
www.thelancet.com/journals/lan...
Thank you so much for having me. It was wonderful to be back @i3suporto.bsky.social in beautiful Porto—my first time since childhood. Fantastic friends and science all around!
Today we had the privilege of having @delafuentelab.bsky.social delivering a fantastic seminar @i3suporto.bsky.social sharing cool ideas on #AI for #antibiotic #discovery! @mobilise.bsky.social
October 15, 2025 at 5:14 AM
Thank you so much for having me. It was wonderful to be back @i3suporto.bsky.social in beautiful Porto—my first time since childhood. Fantastic friends and science all around!
Reposted by César de la Fuente
🎥 @delafuentelab.bsky.social
Uncovering new #antibiotics with #AI | Penn Today
penntoday.upenn.edu/news/uncover...
#MedSky #AImedicine #AI #HealthAI #AIinHealthcare #MedTech
Uncovering new #antibiotics with #AI | Penn Today
penntoday.upenn.edu/news/uncover...
#MedSky #AImedicine #AI #HealthAI #AIinHealthcare #MedTech
Uncovering new antibiotics with AI | Penn Today
César de la Fuente leverages machine learning to accelerate the discovery of lifesaving drugs and help reduce antibiotic resistance, a rising global health problem.
penntoday.upenn.edu
October 6, 2025 at 1:13 PM
🎥 @delafuentelab.bsky.social
Uncovering new #antibiotics with #AI | Penn Today
penntoday.upenn.edu/news/uncover...
#MedSky #AImedicine #AI #HealthAI #AIinHealthcare #MedTech
Uncovering new #antibiotics with #AI | Penn Today
penntoday.upenn.edu/news/uncover...
#MedSky #AImedicine #AI #HealthAI #AIinHealthcare #MedTech
Thank you so much for highlighting our latest work!
Research Highlight: Mining archaea for antibiotics www.nature.com/articles/s41...
Mining archaea for antibiotics - Nature Biotechnology
Nature Biotechnology - Mining archaea for antibiotics
www.nature.com
October 3, 2025 at 3:01 AM
Thank you so much for highlighting our latest work!
Reposted by César de la Fuente
Research Highlight: Mining archaea for antibiotics www.nature.com/articles/s41...
Mining archaea for antibiotics - Nature Biotechnology
Nature Biotechnology - Mining archaea for antibiotics
www.nature.com
September 30, 2025 at 2:59 PM
Research Highlight: Mining archaea for antibiotics www.nature.com/articles/s41...
En España mueren más de 4.000 personas al año por infecciones resistentes a los antibióticos. Urge innovar, sensibilizar y actuar. Gracias COPE por difundir nuestras últimas investigaciones. 🎙️🔬
www.cope.es/programas/he...
www.cope.es/programas/he...
Las bacterias, cada vez más resistentes: "Mueren más personas al año por resistencia a los antibióticos que en accidentes de tráfico"
Jorge Alcalde, desgrana en 'Herrera en COPE', los hallazgos más sorprendentes de la ciencia que conecta el pasado con el presente
www.cope.es
October 1, 2025 at 8:52 AM
En España mueren más de 4.000 personas al año por infecciones resistentes a los antibióticos. Urge innovar, sensibilizar y actuar. Gracias COPE por difundir nuestras últimas investigaciones. 🎙️🔬
www.cope.es/programas/he...
www.cope.es/programas/he...
(1/2) AI is redefining antibiotic discovery. What once took years with traditional methods can now be done in hours.
September 29, 2025 at 9:24 AM
(1/2) AI is redefining antibiotic discovery. What once took years with traditional methods can now be done in hours.