Debraj Ghose
@debrajghose.bsky.social
I study how lymphocytes self-organize into multicellular structures. Also interested in how cells sense and respond to chemical gradients. Currently: Wyss Institute at Harvard. Previously: Comp Bio at Duke. debrajghose.com
2/5 Our computational model predicted that the efficiency of antibody evolution is governed by the tissue's physical state. This motivated our search for chemical signals capable of tuning this material property.
November 18, 2025 at 9:31 PM
2/5 Our computational model predicted that the efficiency of antibody evolution is governed by the tissue's physical state. This motivated our search for chemical signals capable of tuning this material property.
This local memory allows cells to average receptor signals and outperform instantaneous cellular gradient sensing limits.
— Left: classical sensing drifts.
— Right: ratiometric model stays locked on target. 7/n
— Left: classical sensing drifts.
— Right: ratiometric model stays locked on target. 7/n
May 5, 2025 at 10:11 AM
This local memory allows cells to average receptor signals and outperform instantaneous cellular gradient sensing limits.
— Left: classical sensing drifts.
— Right: ratiometric model stays locked on target. 7/n
— Left: classical sensing drifts.
— Right: ratiometric model stays locked on target. 7/n