Ah I see… I’m joining the “it’s all epistasis” team. Thanks!

Yes, I prefer locus=SNP (or indel etc) and so defining this as epistasis. I think there’s always more information if you deal with the “smaller” loci and know the haplotypes. But I guess if you don’t have that level of detail the locus=gene works, no? And I wouldn’t say it’s wrong to treat it as dom

Ah then I think I would be fine with WT dominant to m2, m2 dominant to m1. And I agree it comes down to how you define what is the locus. But also agree with others that if a 4th double mutant allele exists, locus=whole gene doesn’t work well

But with two mutations wouldn’t you have 3 alleles (with locus=whole gene)? So if I understood the example wt=AA, and the double mutant BC would be same as AA. I wouldn’t call it dominance either…

So infuriating!!

... and here's a second #ESEB2025 starter pack!

go.bsky.app/DnUAnt5

Great idea, thanks!

Quem tá no lockdown agora, né

And today I learned this

data <- c()

for (d in 1:200){
for (n in 1:d){
data <- c(data, n/d)
}}

tabd <- table(data)
plot(as.numeric(names(tabd)), tabd, type='l')

Yes, there are theorems and proofs about this, which "every computer scientist should know about". Luckily (?), I'm not a computer scientist :)
docs.oracle.com/cd/E19957-01...