Débora Y C Brandt
@deboraycb.bsky.social
Bióloga do IB-USP 07 🇧🇷 PhD UCBerkeley 🇺🇸 now postdoc at GEE-UCL 🇬🇧
Evolutionary genomics 🧬 🌳 popgen, ARGs, balancing selection. Interested in teaching, conservation. https://profiles.ucl.ac.uk/92078-debora-yoshihara-caldeira-brandt/
Evolutionary genomics 🧬 🌳 popgen, ARGs, balancing selection. Interested in teaching, conservation. https://profiles.ucl.ac.uk/92078-debora-yoshihara-caldeira-brandt/
Pinned
A new preprint from the lab, with postdoc @deboraycb.bsky.social and collaborators @aidaandres.bsky.social and Tim Connallon:
“Characterising the detectable and invisible fractions of genomic loci under balancing selection”
www.biorxiv.org/content/10.6...
“Characterising the detectable and invisible fractions of genomic loci under balancing selection”
www.biorxiv.org/content/10.6...
www.biorxiv.org
Balancing selection maintains some remarkable biological diversity, but detecting it from genomic data alone can be tricky. This may bias our view of its true prevalence. We investigated what makes balancing selection more or less detectable in genomic scans. + in thread & preprint!
Reposted by Débora Y C Brandt
RESEARCH ARTICLE:
Early diet leaves a lasting mark! Mismatched mitochondrial + nuclear genes slow fly development & shift adult food choices. G×E shape metabolism & behaviour:
doi.org/10.1093/jeb/...
@stefanobettinazzi.bsky.social et al. (2025)
@fcamus.bsky.social
@dk-dowling.bsky.social
Early diet leaves a lasting mark! Mismatched mitochondrial + nuclear genes slow fly development & shift adult food choices. G×E shape metabolism & behaviour:
doi.org/10.1093/jeb/...
@stefanobettinazzi.bsky.social et al. (2025)
@fcamus.bsky.social
@dk-dowling.bsky.social
Mitonuclear interactions and early-life diet shape adult nutritional behaviour
Abstract. Mitochondrial function relies on close coordination between the mitochondrial and nuclear genomes. Disruption to this coordination—via mitonuclea
doi.org
January 22, 2026 at 10:20 AM
RESEARCH ARTICLE:
Early diet leaves a lasting mark! Mismatched mitochondrial + nuclear genes slow fly development & shift adult food choices. G×E shape metabolism & behaviour:
doi.org/10.1093/jeb/...
@stefanobettinazzi.bsky.social et al. (2025)
@fcamus.bsky.social
@dk-dowling.bsky.social
Early diet leaves a lasting mark! Mismatched mitochondrial + nuclear genes slow fly development & shift adult food choices. G×E shape metabolism & behaviour:
doi.org/10.1093/jeb/...
@stefanobettinazzi.bsky.social et al. (2025)
@fcamus.bsky.social
@dk-dowling.bsky.social
Reposted by Débora Y C Brandt
A new preprint from the lab, with postdoc @deboraycb.bsky.social and collaborators @aidaandres.bsky.social and Tim Connallon:
“Characterising the detectable and invisible fractions of genomic loci under balancing selection”
www.biorxiv.org/content/10.6...
“Characterising the detectable and invisible fractions of genomic loci under balancing selection”
www.biorxiv.org/content/10.6...
www.biorxiv.org
January 21, 2026 at 3:32 PM
A new preprint from the lab, with postdoc @deboraycb.bsky.social and collaborators @aidaandres.bsky.social and Tim Connallon:
“Characterising the detectable and invisible fractions of genomic loci under balancing selection”
www.biorxiv.org/content/10.6...
“Characterising the detectable and invisible fractions of genomic loci under balancing selection”
www.biorxiv.org/content/10.6...
Reposted by Débora Y C Brandt
Balancing selection maintains some remarkable biological diversity, but detecting it from genomic data alone can be tricky. This may bias our view of its true prevalence. We investigated what makes balancing selection more or less detectable in genomic scans. + in thread & preprint!
A new preprint from the lab, with postdoc @deboraycb.bsky.social and collaborators @aidaandres.bsky.social and Tim Connallon:
“Characterising the detectable and invisible fractions of genomic loci under balancing selection”
www.biorxiv.org/content/10.6...
“Characterising the detectable and invisible fractions of genomic loci under balancing selection”
www.biorxiv.org/content/10.6...
www.biorxiv.org
January 21, 2026 at 4:10 PM
Balancing selection maintains some remarkable biological diversity, but detecting it from genomic data alone can be tricky. This may bias our view of its true prevalence. We investigated what makes balancing selection more or less detectable in genomic scans. + in thread & preprint!
Reposted by Débora Y C Brandt
Balancing selection alert!! 🧬🧪
New preprint where we try to quantify how likely (or rather, unlikely) it is for balancing selection to maintain stable polymorphism, and how easy (or rather, challenging) it is to identify its signatures in genomes.
#Popgen #MolecularEvolution #EvoBio #Science
New preprint where we try to quantify how likely (or rather, unlikely) it is for balancing selection to maintain stable polymorphism, and how easy (or rather, challenging) it is to identify its signatures in genomes.
#Popgen #MolecularEvolution #EvoBio #Science
A new preprint from the lab, with postdoc @deboraycb.bsky.social and collaborators @aidaandres.bsky.social and Tim Connallon:
“Characterising the detectable and invisible fractions of genomic loci under balancing selection”
www.biorxiv.org/content/10.6...
“Characterising the detectable and invisible fractions of genomic loci under balancing selection”
www.biorxiv.org/content/10.6...
www.biorxiv.org
January 21, 2026 at 4:11 PM
Balancing selection alert!! 🧬🧪
New preprint where we try to quantify how likely (or rather, unlikely) it is for balancing selection to maintain stable polymorphism, and how easy (or rather, challenging) it is to identify its signatures in genomes.
#Popgen #MolecularEvolution #EvoBio #Science
New preprint where we try to quantify how likely (or rather, unlikely) it is for balancing selection to maintain stable polymorphism, and how easy (or rather, challenging) it is to identify its signatures in genomes.
#Popgen #MolecularEvolution #EvoBio #Science
Balancing selection maintains some remarkable biological diversity, but detecting it from genomic data alone can be tricky. This may bias our view of its true prevalence. We investigated what makes balancing selection more or less detectable in genomic scans. + in thread & preprint!
A new preprint from the lab, with postdoc @deboraycb.bsky.social and collaborators @aidaandres.bsky.social and Tim Connallon:
“Characterising the detectable and invisible fractions of genomic loci under balancing selection”
www.biorxiv.org/content/10.6...
“Characterising the detectable and invisible fractions of genomic loci under balancing selection”
www.biorxiv.org/content/10.6...
www.biorxiv.org
January 21, 2026 at 4:10 PM
Balancing selection maintains some remarkable biological diversity, but detecting it from genomic data alone can be tricky. This may bias our view of its true prevalence. We investigated what makes balancing selection more or less detectable in genomic scans. + in thread & preprint!
Reposted by Débora Y C Brandt
❗Just two weeks to go!
Please remember to submit your abstract and award application for SMBE 2026 in Copenhagen by February 3.
📨 Abstract submission & Award applications
smbe2026.org/abstracts
📋 Programme details
smbe2026.org/programme
#SMBE2026
Please remember to submit your abstract and award application for SMBE 2026 in Copenhagen by February 3.
📨 Abstract submission & Award applications
smbe2026.org/abstracts
📋 Programme details
smbe2026.org/programme
#SMBE2026
January 20, 2026 at 10:57 AM
❗Just two weeks to go!
Please remember to submit your abstract and award application for SMBE 2026 in Copenhagen by February 3.
📨 Abstract submission & Award applications
smbe2026.org/abstracts
📋 Programme details
smbe2026.org/programme
#SMBE2026
Please remember to submit your abstract and award application for SMBE 2026 in Copenhagen by February 3.
📨 Abstract submission & Award applications
smbe2026.org/abstracts
📋 Programme details
smbe2026.org/programme
#SMBE2026
Reposted by Débora Y C Brandt
We are excited to share our recent work on the surprising robustness of Ancestral Recombination Graph (ARG) inference tools to computational phasing errors, now available on BioRxiv: biorxiv.org/content/10.1....
This work is co-advised by @yundeng.bsky.social and Rasmus Nielsen.
1/7
This work is co-advised by @yundeng.bsky.social and Rasmus Nielsen.
1/7
Robustness of Ancestral Recombination Graph Inference Tools to Phasing Errors
Ancestral Recombination Graphs (ARGs) are fundamental population genetic structures that encode the genealogical history of a sample of haplotypes along the genome. They have recently received substan...
biorxiv.org
November 26, 2025 at 5:09 PM
We are excited to share our recent work on the surprising robustness of Ancestral Recombination Graph (ARG) inference tools to computational phasing errors, now available on BioRxiv: biorxiv.org/content/10.1....
This work is co-advised by @yundeng.bsky.social and Rasmus Nielsen.
1/7
This work is co-advised by @yundeng.bsky.social and Rasmus Nielsen.
1/7
Reposted by Débora Y C Brandt
And we are LIVE! Join us for Day 1️⃣
www.youtube.com/watch?v=rP0X...
#conference #genomics #ERGA @biogeneurope.bsky.social
www.youtube.com/watch?v=rP0X...
#conference #genomics #ERGA @biogeneurope.bsky.social
October 29, 2025 at 2:08 PM
And we are LIVE! Join us for Day 1️⃣
www.youtube.com/watch?v=rP0X...
#conference #genomics #ERGA @biogeneurope.bsky.social
www.youtube.com/watch?v=rP0X...
#conference #genomics #ERGA @biogeneurope.bsky.social
Reposted by Débora Y C Brandt
HHMI adopts Plan U journals.plos.org/plosbiology/...
September 24, 2025 at 6:08 PM
HHMI adopts Plan U journals.plos.org/plosbiology/...
Reposted by Débora Y C Brandt
🇧🇷Saí-de-perna-amarela
🌎Cyanerpes caeruleus
Conservação:Pouco Preocupante
A saí-de-perna-amarela é um Passeriforme da família Thraupidae.
📷 Ester Ramirez
🌎Cyanerpes caeruleus
Conservação:Pouco Preocupante
A saí-de-perna-amarela é um Passeriforme da família Thraupidae.
📷 Ester Ramirez
September 17, 2025 at 2:20 PM
🇧🇷Saí-de-perna-amarela
🌎Cyanerpes caeruleus
Conservação:Pouco Preocupante
A saí-de-perna-amarela é um Passeriforme da família Thraupidae.
📷 Ester Ramirez
🌎Cyanerpes caeruleus
Conservação:Pouco Preocupante
A saí-de-perna-amarela é um Passeriforme da família Thraupidae.
📷 Ester Ramirez
Important heads up! This is crazy
Heads up: ignore samtools dot org, similarly minimap2 dot com and likely others. It's owned by a known phishing site and while the binaries they offer look valid currently (but note they may be serving us different binaries to others), that could change.
Ie: it's not us (Samtools team)! Be warned
Ie: it's not us (Samtools team)! Be warned
September 15, 2025 at 9:31 AM
Important heads up! This is crazy
Reposted by Débora Y C Brandt
Reposted by Débora Y C Brandt
Jasmin Rees PhD chapter as a paper just out at the AJHG @ajhgnews.bsky.social, with Sergi Castellano, who first envisioned the study. Jas investigated signatures of human local genetic adaptation in hundreds of micronutrient-associated genes.
📣New from @aidaandres.bsky.social & co
📄Global impact of micronutrients in modern human evolution
📄Global impact of micronutrients in modern human evolution
Global impact of micronutrients in modern human evolution
In this study, Rees et al. evaluate the role of dietary micronutrients in driving
local genetic adaptation and population differentiation in humans. The authors find
evidence that micronutrient-associ...
www.cell.com
September 10, 2025 at 9:10 PM
Jasmin Rees PhD chapter as a paper just out at the AJHG @ajhgnews.bsky.social, with Sergi Castellano, who first envisioned the study. Jas investigated signatures of human local genetic adaptation in hundreds of micronutrient-associated genes.
Reposted by Débora Y C Brandt
SINGER, our ARG inference method, is finally published and freely available online:
doi.org/10.1038/s415...
It was a long journey – 16 months from initial submission to acceptance. Is it just me, or has peer review gotten more arduous lately? 4+ rounds of review isn't so unusual these days...
doi.org/10.1038/s415...
It was a long journey – 16 months from initial submission to acceptance. Is it just me, or has peer review gotten more arduous lately? 4+ rounds of review isn't so unusual these days...
Robust and accurate Bayesian inference of genome-wide genealogies for hundreds of genomes - Nature Genetics
SINGER is a method for creating ancestral recombination graphs to understand the genealogical history of genomes. The method has increased speed, and thus scalability, without sacrificing accuracy.
doi.org
September 11, 2025 at 3:50 AM
SINGER, our ARG inference method, is finally published and freely available online:
doi.org/10.1038/s415...
It was a long journey – 16 months from initial submission to acceptance. Is it just me, or has peer review gotten more arduous lately? 4+ rounds of review isn't so unusual these days...
doi.org/10.1038/s415...
It was a long journey – 16 months from initial submission to acceptance. Is it just me, or has peer review gotten more arduous lately? 4+ rounds of review isn't so unusual these days...
Reposted by Débora Y C Brandt
📢 The Call for Symposia for SMBE2026 is now open. We warmly invite you to submit a symposium proposal and help shape the scientific content of our annual meeting.
🗓️ Key dates
Call for symposia: Sep. 1 - Oct. 15
Announcement of accepted symposia: Nov. 3
More information: smbe2026.org/symposia
🗓️ Key dates
Call for symposia: Sep. 1 - Oct. 15
Announcement of accepted symposia: Nov. 3
More information: smbe2026.org/symposia
September 9, 2025 at 2:13 PM
📢 The Call for Symposia for SMBE2026 is now open. We warmly invite you to submit a symposium proposal and help shape the scientific content of our annual meeting.
🗓️ Key dates
Call for symposia: Sep. 1 - Oct. 15
Announcement of accepted symposia: Nov. 3
More information: smbe2026.org/symposia
🗓️ Key dates
Call for symposia: Sep. 1 - Oct. 15
Announcement of accepted symposia: Nov. 3
More information: smbe2026.org/symposia
Reposted by Débora Y C Brandt
Excited to share our new preprint🙌
It's the first human WGS study in Sudan. We uncover one of the strongest selection signals to date, pointing to post-admixture adaptation to malaria in Copts. Huge thanks to all co-authors. @aidaandres.bsky.social @jgarcia-cal.bsky.social @ebosch1972.bsky.social
It's the first human WGS study in Sudan. We uncover one of the strongest selection signals to date, pointing to post-admixture adaptation to malaria in Copts. Huge thanks to all co-authors. @aidaandres.bsky.social @jgarcia-cal.bsky.social @ebosch1972.bsky.social
Sudan's complex genetic admixture history drives adaptation to malaria in Sudanese Copts https://www.medrxiv.org/content/10.1101/2025.09.01.25334828v1
September 3, 2025 at 8:24 AM
Excited to share our new preprint🙌
It's the first human WGS study in Sudan. We uncover one of the strongest selection signals to date, pointing to post-admixture adaptation to malaria in Copts. Huge thanks to all co-authors. @aidaandres.bsky.social @jgarcia-cal.bsky.social @ebosch1972.bsky.social
It's the first human WGS study in Sudan. We uncover one of the strongest selection signals to date, pointing to post-admixture adaptation to malaria in Copts. Huge thanks to all co-authors. @aidaandres.bsky.social @jgarcia-cal.bsky.social @ebosch1972.bsky.social
August 22, 2025 at 4:41 PM
Reposted by Débora Y C Brandt
August 14, 2025 at 6:37 PM
Reposted by Débora Y C Brandt
OH COME ON
«GitHub CEO Thomas Dohmke has resigned, and now GitHub will be part of Microsoft’s AI engineering team.» 🫠
https://www.theverge.com/news/757461/microsoft-github-thomas-dohmke-resignation-coreai-team-transition
https://www.theverge.com/news/757461/microsoft-github-thomas-dohmke-resignation-coreai-team-transition
August 11, 2025 at 7:31 PM
OH COME ON
Reposted by Débora Y C Brandt
New Evolution-Digest out! 🎉
Intergenomic discordance should reduce fitness, especially in older males. Well, @martingarlovsky.bsky.social et al., showed that it might not always be the case. 🪰
@sse-evolution.bsky.social
Intergenomic discordance should reduce fitness, especially in older males. Well, @martingarlovsky.bsky.social et al., showed that it might not always be the case. 🪰
@sse-evolution.bsky.social
Digest: Sex-specific benefits of mitochondrial introgression
Abstract. Disrupting mitochondrial and nuclear coadaptation is expected to reduce fitness, especially in males and with age. But is that always true? Garlo
academic.oup.com
August 4, 2025 at 5:00 PM
New Evolution-Digest out! 🎉
Intergenomic discordance should reduce fitness, especially in older males. Well, @martingarlovsky.bsky.social et al., showed that it might not always be the case. 🪰
@sse-evolution.bsky.social
Intergenomic discordance should reduce fitness, especially in older males. Well, @martingarlovsky.bsky.social et al., showed that it might not always be the case. 🪰
@sse-evolution.bsky.social
Reposted by Débora Y C Brandt
Quem tá no lockdown agora, né
July 19, 2025 at 12:35 AM
Quem tá no lockdown agora, né
Reposted by Débora Y C Brandt
When she was just 26 Florence Merriam wrote the first guide to birding with binoculars in 1889. And she slipped in this incredible feminist gem:
July 29, 2025 at 2:14 AM
When she was just 26 Florence Merriam wrote the first guide to birding with binoculars in 1889. And she slipped in this incredible feminist gem:
Reposted by Débora Y C Brandt
Outstanding work by @dcsoto.bsky.social @jmuribescr.bsky.social @mydennis.bsky.social (and other collaborators) that massively advances identification of human gene duplicates, with links to important traits and our evolution. So happy to have contributed a bit to this fantastic paper.
Check out our latest work co-led by @dcsoto.bsky.social and @jmuribescr.bsky.social identifying hundreds of human duplicated gene families using the new T2T-CHM13 assembly, with a focus on those potentially contributing to brain evolution 🧪: authors.elsevier.com/a/1lTQtL7PXu...
authors.elsevier.com
July 22, 2025 at 6:08 AM
Outstanding work by @dcsoto.bsky.social @jmuribescr.bsky.social @mydennis.bsky.social (and other collaborators) that massively advances identification of human gene duplicates, with links to important traits and our evolution. So happy to have contributed a bit to this fantastic paper.
Reposted by Débora Y C Brandt
The University of São Paulo seeks a Professor Doutor in Zoology, specializing in Bioinformatics and Phylogenomics. Applicants should promote research, teaching, and outreach. Details: https://academica.ib.usp.br/concursos/zoologia/edital-19-2025 #job
Instituto de Biociências - Edital 19-2025
EDITAL IB/AAcad/19/2025 (Português)
academica.ib.usp.br
July 16, 2025 at 6:04 PM
The University of São Paulo seeks a Professor Doutor in Zoology, specializing in Bioinformatics and Phylogenomics. Applicants should promote research, teaching, and outreach. Details: https://academica.ib.usp.br/concursos/zoologia/edital-19-2025 #job
I learned this today
>>> round(0.5)
0
>>> round(1.5)
2
>>> round(2.5)
2
>>> round(3.5)
4
>>> round(0.5)
0
>>> round(1.5)
2
>>> round(2.5)
2
>>> round(3.5)
4
July 15, 2025 at 2:34 PM
I learned this today
>>> round(0.5)
0
>>> round(1.5)
2
>>> round(2.5)
2
>>> round(3.5)
4
>>> round(0.5)
0
>>> round(1.5)
2
>>> round(2.5)
2
>>> round(3.5)
4