David B. Blumenthal
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dbblumenthal.bsky.social
David B. Blumenthal
@dbblumenthal.bsky.social
52 followers 56 following 2 posts
Professor for Biomedical Network Science at FAU Erlangen-Nürnberg (https://bionets.tf.fau.de). Opinions are my own.
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Reposted by David B. Blumenthal
romanjoeres.bsky.social
This week I presented DataSAIL at the #ISMBECCB2025 conference in #Liverpool
It has been an amazing chance and experience to meet many people working on information leakage. And getting great ideas to extend it

Nicely supervised by & colaborated with @dbblumenthal.bsky.social @ok55991.bsky.social
July 24, 2025 at 4:03 PM
dbblumenthal.bsky.social
Very happy to see DataSAIL published in @naturecomms.bsky.social. Give it a try if you want to test if your ML models generalize to OOD scenarios. Great collaboration between @uni-saarland.de and @fau.de :-)
romanjoeres.bsky.social Roman Joeres @romanjoeres.bsky.social · Apr 9
DataSAIL is out in @naturecomms.bsky.social
Since the preprint, we have improved the work a lot, thanks to countless reviewers and feedback.

You can find it here: nature.com/articles/s41...

Thanks, @dbblumenthal.bsky.social and @ok55991.bsky.social, for helping and supervising me on this journey.
April 9, 2025 at 8:27 AM
Reposted by David B. Blumenthal
fau.de
Are you ready to challenge yourself and compete with the brightest minds in AI and computer science? 🧠 Join the FAU AI Innovation Challenge 2025! Compete for 10.000€ in prizes in various categories ranging from game AI, cybersecurity & more.

👉 Learn more: go.fau.de/1beg-
A graphic depicting people sitting at desks and working on computers in the foreground. In the background, there are more people standing around in an abstract space. The space itself looks futuristic.
January 27, 2025 at 12:34 PM
dbblumenthal.bsky.social
Deep learning models for sequence-based PPI prediction still fail to yield reliable predictions in challenging scenarios. Great work led by the amazing Timo Reim and @judith-bernett.bsky.social
judith-bernett.bsky.social Judith Bernett @judith-bernett.bsky.social · Jan 27
🧬🖥️ Proud to share our latest update on PPI predictions – "Deep learning models for unbiased sequence-based PPI prediction plateau at an accuracy of 0.65" doi.org/10.1101/2025... by T. Reim, published with @itisalist.bsky.social @dbblumenthal.bsky.social, A. Hartebrodt, and me. What did we do? 1/15 🧵
Graphical summary of the analyses done in the publication displayed on six panels a-f. (a) We computed ESM-2 embeddings of different sizes for the proteins of our data-leakage-free PPI dataset. The per-token embeddings have variable sizes depending on the protein length, while the per-protein embeddings have a fixed size by applying dimension-wise averaging. (b) We tested two models operating on the per-protein embeddings—a baseline random forest classifier and adaptions of the previously published Richoux model. Five models operated on the per-token embeddings: a 2d-baseline, the 2d-Selfattention and 2d-Crossattention models (which expanded the 2d-baseline through a Transformer encoder), and adaptations of the published models D-SCRIPT and TUnA. (c) Hyperparameter tuning gave us insight into the influence of each tunable parameter on the classification performance. (d) No model surpassed an accuracy of 0.65. The more advanced models had similar accuracies, leading us to believe that the information content of the ESM-2 embedding has more influence than the model architecture. Per-token models did not consistently outperform per-protein models. (e) We applied various modifications to test their influence: different embedding sizes, inserting a Transformer encoder into different positions, adding spectral normalization after the linear layers, self- vs. cross-attention, and removing the padding. (f) Finally, we compared the implicitly predicted distance maps of the 2d-baseline, 2d-Selfattention, 2dCrossattention, and D-SCRIPT-ESM-2 to real distance maps computed from PDB structures.
January 27, 2025 at 11:50 AM
Reposted by David B. Blumenthal
judith-bernett.bsky.social
🧬🖥️ Proud to share our latest update on PPI predictions – "Deep learning models for unbiased sequence-based PPI prediction plateau at an accuracy of 0.65" doi.org/10.1101/2025... by T. Reim, published with @itisalist.bsky.social @dbblumenthal.bsky.social, A. Hartebrodt, and me. What did we do? 1/15 🧵
Graphical summary of the analyses done in the publication displayed on six panels a-f. (a) We computed ESM-2 embeddings of different sizes for the proteins of our data-leakage-free PPI dataset. The per-token embeddings have variable sizes depending on the protein length, while the per-protein embeddings have a fixed size by applying dimension-wise averaging. (b) We tested two models operating on the per-protein embeddings—a baseline random forest classifier and adaptions of the previously published Richoux model. Five models operated on the per-token embeddings: a 2d-baseline, the 2d-Selfattention and 2d-Crossattention models (which expanded the 2d-baseline through a Transformer encoder), and adaptations of the published models D-SCRIPT and TUnA. (c) Hyperparameter tuning gave us insight into the influence of each tunable parameter on the classification performance. (d) No model surpassed an accuracy of 0.65. The more advanced models had similar accuracies, leading us to believe that the information content of the ESM-2 embedding has more influence than the model architecture. Per-token models did not consistently outperform per-protein models. (e) We applied various modifications to test their influence: different embedding sizes, inserting a Transformer encoder into different positions, adding spectral normalization after the linear layers, self- vs. cross-attention, and removing the padding. (f) Finally, we compared the implicitly predicted distance maps of the 2d-baseline, 2d-Selfattention, 2dCrossattention, and D-SCRIPT-ESM-2 to real distance maps computed from PDB structures.
January 27, 2025 at 10:59 AM
Reposted by David B. Blumenthal
itisalist.bsky.social
Incredibly happy to finally see our manuscript "Emergence of power-law distributions in protein-protein interaction networks through study bias" published in @elife.bsky.social. doi.org/10.7554/eLif... It's been a long but fun journey with @dbblumenthal.bsky.social and @martinschaefer.bsky.social
Emergence of power-law distributions in protein-protein interaction networks through study bias
doi.org
December 14, 2024 at 7:47 PM
Reposted by David B. Blumenthal
judith-bernett.bsky.social
🧬💻Transferring my paper posts here, starting off with "Cracking the black box of deep sequence-based protein-protein interaction prediction" doi.org/10.1093/bib/..., which I published together with @itisalist.bsky.social and @dbblumenthal.bsky.social. So what was it about? 1/13 🧵
Overview figure summarizing the major analyses of the paper. In the setting employed by published methods, performances are strongly inflated regardless of model and dataset. When the positive training dataset is randomly rewired, there is only a slight decrease in performance. When the models are evaluated on unseen proteins that are unsimilar to the training proteins, performances become random.
November 28, 2024 at 9:10 AM
Reposted by David B. Blumenthal
judith-bernett.bsky.social
🧬🖥️Tranferring my papers, Pt. 2: "Guiding questions to avoid data leakage in biological machine learning applications" doi.org/10.1038/s41592-024-02362-y, which I published with @itisalist.bsky.social @dbblumenthal.bsky.social @romanjoeres.bsky.social, D. Grimm, F. Haselbeck, and O.V. Kalinina. 🧵1/20
Overview figure of the seven guiding questions addressed in manuscript regarding (1) Study bias, (2) Label distribution, (3) Data shift, (4) Inter-sample similarities, (5) Unavailable features, (6) Features as illegitimate surrogates, (7) Pretraining
December 2, 2024 at 11:53 AM
Reposted by David B. Blumenthal
jorainer.bsky.social
Reminder: #computational_biology position available in my team:

- large-scale #proteomics #metabolomics data analysis
- #rstats , #python, #machinelearning
- great living in the ❤️ of the 🇮🇹 Alps ⛰️

👉 info and apply: bit.ly/3wztFsN
March 1, 2024 at 7:52 AM