Preserving intracellular glutamate supports CD8 T cell anti tumour function.

Research from the Rathmell lab point to Glutamine synthetase a potential target for cancer immunotherapy

academic.oup.com/jimmunol/art...

10,000 people marched in Dublin this weekend. Ireland stands against genocide. Free Palestine.

Metabolic #plasticity to Slc1a5 loss involving upregulation of macropinocytosis.

Important also for #immune cells to support glutamine requirements?
#immunometabolism

“Macropinocytosis mediates resistance to loss of glutamine transport in TNBC” www.embopress.org/doi/full/10....

And from National University of Ireland Maynooth (NUIM), Eimear Ryan from @andyhogan82.bsky.social lab will present her work at the December @immunometforum.bsky.social on #MAITcell #metabolism.

#immmunosky #immunoology #immunometabolism

From Leiden in the Netherlands, @thiagoapatente.bsky.social from Bart Everts lab will present work at the December @immunometforum.bsky.social on #DCs and #Tregs.

#immmunosky #immunoology #immunometabolism

From Madrid in Spain, Gillian Dunphy from the @sancholab.bsky.social lab will present her work c on #macrophages and #mitochondria.

#immmunosky #immunoology #immunometabolism

The December @immunometforum.bsky.social will
take place this Friday with three great early career researcher presenting:
🧵1/4

#immmunosky #immunoology #immunometabolism

New review article written by Cristhiane Favero de Aguiar and Carrie Corkish from my lab. They did a great job.

www.nature.com/articles/s41...

#SingleCell #Immunometabolism
#ImmunoSky

Approaches to investigate tissue-resident innate lymphocytes metabolism at the single-cell level

Long chain acyl-carnitine Palmitoylcarnitine is elevated in diseases including T2D and obesity, and this study suggests it can cause mitochondrial dysfunction in immune cells.

Palmitoylcarnitine impairs immunity in decompensated cirrhosis - JHEP Reports www.jhep-reports.eu/article/S258...

Interesting, a fluorescent biosensors to illuminate arginine metabolism in cells, mice, and clinical samples.

#Arginine #biosensor

Lighting up arginine metabolism reveals its functional diversity in physiology and pathology: Cell Metabolism www.cell.com/cell-metabol...

Another lactate dependent immunosuppressant mechanism, here in Glioblastoma

#GBM #Lactate #CD47 #HistoneLactylation

JCI - Lactate reprograms glioblastoma immunity through CBX3-regulated histone lactylation www.jci.org/articles/vie...

Interesting link between high glucose in T2D patients and impaired T cells responses towards virus.

#LipidPeroxidation
#TcellSignalling
#T2D

Hyperglycemia-triggered lipid peroxidation destabilizes STAT4 and impairs anti-viral Th1 responses in type 2 diabetes

www.sciencedirect.com/science/arti...