David Finlay
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davidfinlaytcd.bsky.social
David Finlay
@davidfinlaytcd.bsky.social
1.8K followers 960 following 48 posts
Interested in all things Immunometabolism
ORCID:0000-0003-2716-6679
Saoirse don Phailistín
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davidfinlaytcd.bsky.social
David Finlay @davidfinlaytcd.bsky.social · Nov 30
New review article written by Cristhiane Favero de Aguiar and Carrie Corkish from my lab. They did a great job.

www.nature.com/articles/s41...

#SingleCell #Immunometabolism
#ImmunoSky

Approaches to investigate tissue-resident innate lymphocytes metabolism at the single-cell level
davidfinlaytcd.bsky.social
Hexokinase 2, the latest glycolytic enzyme that also controls mRNA translation!

Nonmetabolic function of HK2 acting as an RBP and translation regulator.

dx.plos.org/10.1371/jour...
Hexokinase 2 is an RNA-binding protein that regulates mRNA translation independently of glycolysis and induces melanoma cell proliferation
Hexokinase 2 (HK2) is traditionally known for its metabolic role in glycolysis. This study shows that it also functions as an RNA-binding protein that regulates mRNA translation, particularly of SOX10...
dx.plos.org
November 9, 2025 at 5:15 PM
davidfinlaytcd.bsky.social
Preserving intracellular glutamate supports CD8 T cell anti tumour function.

Research from the Rathmell lab point to Glutamine synthetase a potential target for cancer immunotherapy

academic.oup.com/jimmunol/art...
November 6, 2025 at 2:16 PM
davidfinlaytcd.bsky.social
Ireland must act now.
Our government has failed to defend international law, failed to protect Irish citizens detained in international waters, and failed to enact the Occupied Territories Bill.

We demand action:
1️⃣ Implement the ICJ’s findings.
2️⃣ Enact the Occupied Territories Bill.
October 10, 2025 at 9:52 AM
Reposted by David Finlay
frezzalab.bsky.social
Peroxisomal metabolism of branched fatty acids regulates energy homeostasis

www.nature.com/articles/s41...
Peroxisomal metabolism of branched fatty acids regulates energy homeostasis - Nature
A UCP1-independent mechanism of thermogenesis involving ATP-consuming metabolism of monomethyl branched-chain fatty acids in peroxisomes is described and a previously unrecognized role for peroxisomes...
www.nature.com
September 17, 2025 at 4:18 PM
davidfinlaytcd.bsky.social
Caution : Expression of p-glycoprotein (ABCB1b) affects mitochondrial staining with MTG and TMRM

1-3k copies in NK cells.

Assess mitochondrial mass using multiple methods.
-10-nonyl acridine orange (NA0) stains mito-specific lipid cardiolipin,
-Antibody staining of proteins like ATP5b
October 5, 2025 at 10:49 PM
davidfinlaytcd.bsky.social
In case you missed it….great study from @lindavsinclair.bsky.social and Doreen Cantrell.

Autophagy and how it shapes CD8 T cell responses

-Differentially pruning naive and effector T cell proteomes
-Dynamically repressed by antigen receptors and inflammatory cytokines

rdcu.be/eJBFA
Autophagy repression by antigen and cytokines shapes mitochondrial, migration and effector machinery in CD8 T cells
Nature Immunology - Sinclair et al. combine quantitative proteomics and an autophagy flux reporter to map autophagy substrates and triggers during CD8 T cell differentiation. Proteins...
rdcu.be
October 5, 2025 at 9:54 PM
davidfinlaytcd.bsky.social
Exercise-induced Metabolite N-lactoyl-phenylalanine Ameliorates Colitis by Inhibiting M1 Macrophage Polarization. www.cmghjournal.org/article/S235...

Wonder how metformin induced LacPhe (pmc.ncbi.nlm.nih.gov/articles/PMC...) affects macrophages and gut inflammation. @immunometforum.bsky.social
Exercise-induced Metabolite N-lactoyl-phenylalanine Ameliorates Colitis by Inhibiting M1 Macrophage Polarization via the Suppression of the NF-κB Signaling Pathway
Although the anti-inflammatory benefits of exercise are well-documented, the specific mechanisms responsible for these advantages remain uncertain. N-lactoyl-phenylalanine (Lac-Phe), a major metabolit...
www.cmghjournal.org
October 4, 2025 at 1:28 PM
davidfinlaytcd.bsky.social
Maternal obesity alters function of offspring’s liver Kupffer cells leading to fatty liver disease.
Reprogramming during gestation requires #HIF1alpha.
Nice 👌. @masslab.bsky.social
I wonder how altered KC affects immunometabolism of other liver resident cells?
www.nature.com/articles/s41...
Kupffer cell programming by maternal obesity triggers fatty liver disease - Nature
In a mouse model, maternal obesity during pregnancy can lead to fatty liver disease in the offspring, driven by aberrant developmental programming of Kuppfer cells.
www.nature.com
September 28, 2025 at 11:38 AM
davidfinlaytcd.bsky.social
ENPP1 senses cytosolic mtDNA and promotes increased Slc2a1 and glucose uptake. Ultimately contributes to mal-differentiation of T cells in SLE #mTorc1 #AMPK

Cell Reports www.cell.com/cell-reports...
ENPP1 governs the metabolic regulation of effector T cells in autoimmunity by detecting cytosolic mitochondrial DNA
Ji et al. demonstrate an abnormal differentiation of effector T cells in human SLE, identifying new functions of ENPP1 as an mtDNA sensor and transcription factor. ENPP1 sensing of mtDNA promotes the ...
www.cell.com
September 27, 2025 at 3:55 PM
davidfinlaytcd.bsky.social
Interesting insights into why iron is important for T cell proliferation, from @drakesmith-lab.bsky.social and Megan Teh (linkedin.com/in/megan-teh...) @ox.ac.uk

Iron scarcity creates a mitochondrial-located metabolic bottleneck in CD8 T cells.

www.nature.com/articles/s41...
Iron deficiency causes aspartate-sensitive dysfunction in CD8+ T cells - Nature Communications
Iron has been shown to be necessary for the activation and differentiation of CD8+ T cells. Here the authors investigate changes in CD8+ T cell metabolism in iron limiting conditions and find that aspartate is increased yet downstream nucleotide synthesis is suppressed and addition of exogenous aspartate partially rescues T cell function.
www.nature.com
September 27, 2025 at 3:44 PM
davidfinlaytcd.bsky.social
An interesting new angle on trained immunity and coagulation. Nice study by @aislingrehill.bsky.social and @rogerpreston.bsky.social from @rcsi.bsky.social

@researchireland.ie

pmc.ncbi.nlm.nih.gov/articles/PMC...
Trained immunity causes myeloid cell hypercoagulability
The pathogenic basis for increased thrombotic risk in individuals with inflammatory diseases is poorly understood. Myeloid cell “trained immunity” describes persistent innate immune cell memory arisin...
pmc.ncbi.nlm.nih.gov
September 27, 2025 at 12:45 AM
Reposted by David Finlay
philipoconnor.bsky.social
At an absolute minimum, Ireland must immediately pass the full Occupied Territories Bill (NOT the watered-down version) & end the transport of Israeli war matériel through Irish airspace.
And every Irish voter should be calling their TD tomorrow to ensure it happens.
www.ohchr.org/en/press-rel...
Israel has committed genocide in the Gaza Strip, UN Commission finds
GENEVA – Israel has committed genocide against Palestinians in the Gaza Strip, the UN Independent International Commission of Inquiry on the Occupied Palestinian Territory, including East Jerusalem, a...
www.ohchr.org
September 16, 2025 at 8:46 PM
Reposted by David Finlay
ipsc.bsky.social
Please take this easy action, we must see sanctions on apartheid Israel for its genocide of Palestinians, we need, as a first step, the full Occupied Territories Bill enacted. #SanctionsNow
Act now for Palestine – rescue the Occupied Territories Bill
www.trocaire.org/petitions/ac...
Act now for Palestine - rescue the Occupied Territories Bill - Trócaire
www.trocaire.org
September 17, 2025 at 8:44 PM
davidfinlaytcd.bsky.social
10,000 people marched in Dublin this weekend. Ireland stands against genocide. Free Palestine.
10,000 people marched this weekend in Dublin, Ireland
July 22, 2025 at 9:50 AM
Reposted by David Finlay
erictopol.bsky.social
A systematic review involving >130 million people and 1 million dementia cases found that anti-inflammatory medications, vaccinations, and antibiotics were associated with reduced dementia, whereas vitamins and supplements linked to higher risk
alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
Data‐driven discovery of associations between prescribed drugs and dementia risk: A systematic review
Abstract Recent clinical trials on slowing dementia progression have led to renewed focus on finding safer, more effective treatments. One approach to identify plausible candidates is to assess whet...
alz-journals.onlinelibrary.wiley.com
January 21, 2025 at 3:05 PM
Reposted by David Finlay
labliston.bsky.social
Our paper on nurturing a #PositiveResearchCulture within your #research #team published by @wellcometrust.bsky.social gives useful tips for your lab. As well as making you a good team leader, nurturing culture pays off in building your science: 1/11

wellcomeopenresearch.org/articles/9-3...
wellcomeopenresearch.org
January 14, 2025 at 9:55 AM
davidfinlaytcd.bsky.social
Lots of interest in how to maintain healthy mitochondria for effective cell therapy, like #NKcells for cancer immunotherapy. Some interesting clues in this article.
#immunosky #immunometabolism

Triacylglycerol mobilization underpins mitochondrial stress recovery
www.nature.com/articles/s41...
Triacylglycerol mobilization underpins mitochondrial stress recovery - Nature Cell Biology
Baker et al. show that mitochondrial stress recovery requires mobilization of lipid droplet triacylglycerol stores to facilitate cardiolipin biosynthesis and mitochondrial biogenesis.
www.nature.com
January 15, 2025 at 1:30 AM
davidfinlaytcd.bsky.social
Exciting work from Sue Kaech’s lab @tcellogic.bsky.social

Tissue specific metabolites like #BileAcids in #Liver affect #CD8Tcell tumour responses

#immunometabolism #immunosky

Bile acid synthesis impedes tumor-specific T cell responses during liver cancer www.science.org/doi/10.1126/...
Bile acid synthesis impedes tumor-specific T cell responses during liver cancer
The metabolic landscape of cancer greatly influences antitumor immunity, yet it remains unclear how organ-specific metabolites in the tumor microenvironment influence immunosurveillance. We found that...
www.science.org
January 15, 2025 at 1:15 AM
davidfinlaytcd.bsky.social
More nice research from Annie Curtis’ lab on the circadian rhythm and the
#immunometabolism of macrophages.

#immunosky #mitochondria #inflammasome

Time‐of‐day control of mitochondria regulates NLRP3 inflammasome activation in macrophages faseb.onlinelibrary.wiley.com/doi/10.1096/...
Time‐of‐day control of mitochondria regulates NLRP3 inflammasome activation in macrophages
The circadian clock, orchestrated by BMAL1, regulates the expression of Nlrp3 and Il1b in response to lipopolysaccharide (LPS), causing time-of-day production of pro-IL-1β. Mitochondria exhibit time-....
faseb.onlinelibrary.wiley.com
January 15, 2025 at 12:31 AM
davidfinlaytcd.bsky.social
PKM2 has always been intriguing; complex roles in some cells, here involving adenosine in #macrophages, simple glycolytic enzyme in #NKcells (doi.org/10.7554/eLif...)
#immunometabolism #immunosky
Metabolic reprogramming of macrophages by PKM2 promotes IL-10 via adenosine www.cell.com/cell-reports...
Metabolic reprogramming of macrophages by PKM2 promotes IL-10 production via adenosine
TEPP-46 activates PKM2 by inducing a tetramer formation, which leads to a metabolic reprogramming in macrophages, resulting in an increase in ATP and IL-10 production. Toller-Kawahisa et al. showed th...
www.cell.com
January 15, 2025 at 12:21 AM
Reposted by David Finlay
karen--s.bsky.social
Check out our new commentary on this interesting study by @justinaguerrero.bsky.social and team on Glut1 overexpressing CAR T cells. Excited to see what comes next for these metabolically enhanced T cells!
@davidfinlaytcd.bsky.social
La dolce vita: fueling chimeric antigen receptor (CAR) T... : Immunometabolism
y of patients relapse, which is concomitant with poor CAR T cell persistence. Similarly, the efficacy of CAR T cell therapy is limited in solid tumors, largely due to tumor antigen heterogeneity, immu...
journals.lww.com
January 13, 2025 at 1:33 PM
davidfinlaytcd.bsky.social
La dolce vita: fueling chimeric antigen receptor (CAR) T... : Immunometabolism
#immunometabolism #immunosky #glucose #CAR-T

journals.lww.com/immunometabo...
La dolce vita: fueling chimeric antigen receptor (CAR) T... : Immunometabolism
y of patients relapse, which is concomitant with poor CAR T cell persistence. Similarly, the efficacy of CAR T cell therapy is limited in solid tumors, largely due to tumor antigen heterogeneity, immu...
journals.lww.com
January 13, 2025 at 10:08 AM
davidfinlaytcd.bsky.social
Interesting new oxysterol research from Jason Cyster’s lab.

EBI2 (GPR183) and oxysterol ligand 7α,25-HC are required for lymphocyte homing to inflamed LNs.
#immunology #oxysterols
Inflammation switches the chemoattractant requirements for naive lymphocyte entry into LN www.cell.com/cell/fulltex...
Inflammation switches the chemoattractant requirements for naive lymphocyte entry into lymph nodes
Lymph node swelling is a well-known symptom of infection. A shift in the chemoattractant code controls lymphocyte recruitment from blood into inflamed lymph nodes, allowing lymphocytes to accumulate so that even rare antigen-specific cells can encounter their activating antigen.
www.cell.com
January 6, 2025 at 10:13 AM
Reposted by David Finlay
ryanlab.bsky.social
📢Preprint alert! Very excited to share the first preprint from the lab spearheaded by stellar postdoc Eloïse Marques. An inherited mtDNA mutation remodels inflammatory cytokine responses in macrophages and in vivo. 1/n
www.biorxiv.org/content/10.1...
An inherited mtDNA mutation remodels inflammatory cytokine responses in macrophages and in vivo
Impaired mitochondrial bioenergetics in macrophages can drive hyperinflammatory cytokine responses, but whether this may also be caused by inherited mtDNA mutations is unknown. Here, we address this q...
www.biorxiv.org
January 6, 2025 at 9:34 AM
davidfinlaytcd.bsky.social
Metabolic #plasticity to Slc1a5 loss involving upregulation of macropinocytosis.

Important also for #immune cells to support glutamine requirements?
#immunometabolism

“Macropinocytosis mediates resistance to loss of glutamine transport in TNBC” www.embopress.org/doi/full/10....
January 5, 2025 at 11:38 PM