@davemomi.bsky.social
Computational cognitive neuroscientist 🧠 | Former pro 🏀 | Calisthenics athlete 💪 |
@DJIGlobal Pilot 🚁 |
Post-Doctoral Research Fellow @StanfordBrain
@DJIGlobal Pilot 🚁 |
Post-Doctoral Research Fellow @StanfordBrain
11/11 Sincere thanks to our editors and reviewers at @naturecomms.bsky.social, and to all our collaborators at @camhnews.bsky.social, @stanfordbrain.bsky.social, @stanfordpntlab.bsky.social, @stanfordmedicine.bsky.social and @Università Milano who made this work possible!
a cartoon of patrick and spongebob with the words team work below them
ALT: a cartoon of patrick and spongebob with the words team work below them
media.tenor.com
April 5, 2025 at 2:43 PM
11/11 Sincere thanks to our editors and reviewers at @naturecomms.bsky.social, and to all our collaborators at @camhnews.bsky.social, @stanfordbrain.bsky.social, @stanfordpntlab.bsky.social, @stanfordmedicine.bsky.social and @Università Milano who made this work possible!
10/11 These findings have exciting implications for brain stimulation therapies in psychiatry and neurology. Targeting high-order vs low-order networks might require completely different stimulation approaches!
April 5, 2025 at 2:43 PM
10/11 These findings have exciting implications for brain stimulation therapies in psychiatry and neurology. Targeting high-order vs low-order networks might require completely different stimulation approaches!
9/11 As
@DanteSommoPoeta
wrote: "The more perfect a thing is, the more it feels." In the brain, like basketball, star players like
@Lebron James
(cognitive networks) react dramatically to game changes while role players (sensory networks) maintain steadier, independent performance.
@DanteSommoPoeta
wrote: "The more perfect a thing is, the more it feels." In the brain, like basketball, star players like
@Lebron James
(cognitive networks) react dramatically to game changes while role players (sensory networks) maintain steadier, independent performance.
lebron james is wearing a yellow lakers jersey with the number 23
ALT: lebron james is wearing a yellow lakers jersey with the number 23
media.tenor.com
April 5, 2025 at 2:43 PM
9/11 As
@DanteSommoPoeta
wrote: "The more perfect a thing is, the more it feels." In the brain, like basketball, star players like
@Lebron James
(cognitive networks) react dramatically to game changes while role players (sensory networks) maintain steadier, independent performance.
@DanteSommoPoeta
wrote: "The more perfect a thing is, the more it feels." In the brain, like basketball, star players like
@Lebron James
(cognitive networks) react dramatically to game changes while role players (sensory networks) maintain steadier, independent performance.
8/11 Meanwhile, low-order sensory networks were barely affected by removing these feedback connections! Their responses remained strong, suggesting they rely mostly on local processing rather than whole-brain feedback.
April 5, 2025 at 2:43 PM
8/11 Meanwhile, low-order sensory networks were barely affected by removing these feedback connections! Their responses remained strong, suggesting they rely mostly on local processing rather than whole-brain feedback.
7/11 The results were striking: high-order networks NEED feedback from the rest of the brain to generate their full response. When we cut these feedback connections, their responses were significantly reduced.
April 5, 2025 at 2:43 PM
7/11 The results were striking: high-order networks NEED feedback from the rest of the brain to generate their full response. When we cut these feedback connections, their responses were significantly reduced.
6/11 But why? To understand the mechanism, we built computational models of each patient's brain based on their anatomical connections, and then performed "virtual dissections" - selectively removing connections between networks.
April 5, 2025 at 2:43 PM
6/11 But why? To understand the mechanism, we built computational models of each patient's brain based on their anatomical connections, and then performed "virtual dissections" - selectively removing connections between networks.
5/11 We discovered an "excitability gradient" across the brain! High-order cognitive networks (like the Default Mode Network) showed much stronger responses to stimulation than low-order sensory networks.
April 5, 2025 at 2:43 PM
5/11 We discovered an "excitability gradient" across the brain! High-order cognitive networks (like the Default Mode Network) showed much stronger responses to stimulation than low-order sensory networks.
4/11 Based on our previous computational modeling work (elifesciences.org/articles/83232), we used rare data from 36 epilepsy patients, recording brain activity during 323 electrical stimulation sessions. This gave us a unique window into how stimulation activates different brain regions!
TMS-evoked responses are driven by recurrent large-scale network dynamics
Whole-brain computational modelling, incorporating novel ML-based parameter estimation techniques, reveals how transcranial magnetic stimulation-evoked brain responses are driven at earlier timepoints...
elifesciences.org
April 5, 2025 at 2:43 PM
4/11 Based on our previous computational modeling work (elifesciences.org/articles/83232), we used rare data from 36 epilepsy patients, recording brain activity during 323 electrical stimulation sessions. This gave us a unique window into how stimulation activates different brain regions!
3/11 Building on
@Daniel S. Margulies' seminal work on the "principal gradient" of brain organization (pnas.org/doi/10.1073/...), we asked how these different networks respond to direct electrical stimulation.
@Daniel S. Margulies' seminal work on the "principal gradient" of brain organization (pnas.org/doi/10.1073/...), we asked how these different networks respond to direct electrical stimulation.
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
pnas.org
April 5, 2025 at 2:43 PM
3/11 Building on
@Daniel S. Margulies' seminal work on the "principal gradient" of brain organization (pnas.org/doi/10.1073/...), we asked how these different networks respond to direct electrical stimulation.
@Daniel S. Margulies' seminal work on the "principal gradient" of brain organization (pnas.org/doi/10.1073/...), we asked how these different networks respond to direct electrical stimulation.
2/11 The human brain has a fascinating organization: from simple sensory regions to complex cognitive networks. We wondered: do these different networks respond differently when stimulated? And does this follow the brain's known hierarchical organization?
academic.oup.com/brain/articl...
academic.oup.com/brain/articl...
From sensation to cognition.
Abstract. Sensory information undergoes extensive associative elaboration and attentional modulation as it becomes incorporated into the texture of cogniti
academic.oup.com
April 5, 2025 at 2:43 PM
2/11 The human brain has a fascinating organization: from simple sensory regions to complex cognitive networks. We wondered: do these different networks respond differently when stimulated? And does this follow the brain's known hierarchical organization?
academic.oup.com/brain/articl...
academic.oup.com/brain/articl...