Someone shared this interaction with me - Any thoughts by senior academics on this situation ? #academicsky #medski #phd #authorship #academic #journal

Cheers to another trip around the sun! 🌍 Here’s to 365 more days of discovering, questioning, and being marvelously curious. Let’s make 2025 a year of stellar ideas and quantum leaps! ✨ Happy New Year 🎊

This is what FREEDOM OF SPEECH looks like 👍

This message is approved by Donald Trump

Self destruct sequence initiated 😂
Elon might be coming to Bluesky soon

Burnsssss

My CIRCLE is literally widening 😂

Humans vs Ants attempting the “PIANO MOVERS PROBLEMS”

Prof. Ofer Feinerman and his team at the Weizmann Institute of Science made this evolutionary competition that asks the question: Who will be better at maneuvering a large load through a maze?

Wishing you all a Christmas filled with health, hope, and healing. May it brings you joy and inspire compassion for the year ahead. #MerryChristmas #Phdsky #academicsky #neurosky #healthsky #sky #bksy

8. A ‘liability threshold’ model for rare genetic diseases

Rare and common genetic variants, and environmental factors, combine to determine disease risk, and the threshold is often reached due to multiple common variants

www.nature.com/articles/d41...

7. In the biggest study of its kind, plasma proteomics of 53,026 patients identified new drug targets, and new diagnostic biomarkers

www.cell.com/cell/fulltex...

6. Adding more options for Crohn’s

This is a positive phase 3 trial of Mirikizumab, an inhibitor of the p19 subunit of IL-23

If approved for Crohn's (it already is for ulcerative colitis), this would add to other biologic options, and JAK inhibitors

www.thelancet.com/journals/lan...

5. Achondroplasia causes short height due to activating mutations in FGFR3

In this phase 2 trial of children aged 3-11, an FGFR inhibitor roughly doubled the rate of growth

It had some adverse effects, but none severe enough to stop treatment

www.nejm.org/doi/full/10....

4. Lipoprotein(a) causes atherosclerosis and aortic valve stenosis, but it's genetically determined - unaffected by exercise or diet, and there are no effective drugs to lower it

2. Why’s it so hard to keep weight off after losing it?

Obesity leaves an epigenetic mark, that alters transcription long-term and negatively affects adipocyte function

This makes later weight gain more likely, and explains the dieting 'yo-yo' effect

www.nature.com/articles/s41...

Biggest medical discoveries of the week (🧵)

1/8

A malaria vaccine - attenuated P. falciparum arrested in the late liver stage - provided 89% protection in a trial of 9 people

This could improve the modest, short-lived protection of current vaccines

www.nejm.org/doi/full/10....

Bluesky now has over 10 million users, and I was #6,021,258!