Hi Peter. I’m working on translation longevity with Healthspan.

I use typefully

If you’re not participating in structured exercise, consuming a high-protein diet may cause some level of metabolic damage in the long term due to impaired insulin sensitivity, increased insulin-glucagon, and impaired suppression of hepatic glucose production.

Exercise prevented all the negative effects associated with high-protein diets.

While the human and animal data suggest that increased protein intake is bad for metabolic health, some people consuming the highest protein levels–athletes–are metabolically very healthy.

Notably, the high-protein diet, when combined with exercise training, resulted in greater gains in lean mass, with no impairments to glycaemic control or the accumulation of fat mass observed in the non-exercise, high-protein group.

In @michaelamrd’s low-protein vs high-protein investigation, they had an additional two groups which consumed the same low/high protein diets but with the addition of resistance-type exercise.

The reduced mTOR activity still results in increases in muscle protein synthesis and increased muscle mass over time.

It’s worthy of note those adults that reported the greatest gains in muscle mass actually observed the greatest inhibition of genes related to mTOR.

A common misconception is a desire to repeatedly initiate mTOR activity to maximize muscle growth.

Although acute exercise increases mTOR & muscle protein synthesis, repeated chronic exposure to resistance training actually results in a decrease in mTOR activity over time.

The increased body mass and adiposity also resulted in a 22% increase in fasting blood glucose and a 35% reduction in glycaemic control in response to a glucose tolerance test.

What's causing this increase in adiposity and elevated glucose levels?