Daniel Tawfik
@dantawfik.bsky.social
Founder and developer http://gethealthspan.com. Molecular biologist turned dev. product of big government
@ucla
@ucla
Reposted by Daniel Tawfik
🧠 Is Alzheimer’s really a disease of misfolded proteins—or a crisis of cellular energy?
For decades, the dominant theory of Alzheimer’s disease has focused on the growth of amyloid plaques. But a growing body of research points to a different culprit that may come earlier: mitochondrial dysfunction
For decades, the dominant theory of Alzheimer’s disease has focused on the growth of amyloid plaques. But a growing body of research points to a different culprit that may come earlier: mitochondrial dysfunction
May 4, 2025 at 6:52 PM
🧠 Is Alzheimer’s really a disease of misfolded proteins—or a crisis of cellular energy?
For decades, the dominant theory of Alzheimer’s disease has focused on the growth of amyloid plaques. But a growing body of research points to a different culprit that may come earlier: mitochondrial dysfunction
For decades, the dominant theory of Alzheimer’s disease has focused on the growth of amyloid plaques. But a growing body of research points to a different culprit that may come earlier: mitochondrial dysfunction
Reposted by Daniel Tawfik
For years, midlife weight gain in women was blamed on a simple drop in estrogen. But new research shows it’s far more complex—and it at least partially starts in the brain.
April 24, 2025 at 12:00 AM
For years, midlife weight gain in women was blamed on a simple drop in estrogen. But new research shows it’s far more complex—and it at least partially starts in the brain.
Reposted by Daniel Tawfik
1. 🧠 What if Alzheimer’s isn’t caused by plaques at all—but by an energy crisis inside your brain cells?
The research of Dr. Francisco Gonzalez-Lima on mitochondrial dysfunction in AD—and the potential of methylene blue to restore neuronal energy—you see a radically different framing of the disease
The research of Dr. Francisco Gonzalez-Lima on mitochondrial dysfunction in AD—and the potential of methylene blue to restore neuronal energy—you see a radically different framing of the disease
April 8, 2025 at 1:39 AM
1. 🧠 What if Alzheimer’s isn’t caused by plaques at all—but by an energy crisis inside your brain cells?
The research of Dr. Francisco Gonzalez-Lima on mitochondrial dysfunction in AD—and the potential of methylene blue to restore neuronal energy—you see a radically different framing of the disease
The research of Dr. Francisco Gonzalez-Lima on mitochondrial dysfunction in AD—and the potential of methylene blue to restore neuronal energy—you see a radically different framing of the disease
Reposted by Daniel Tawfik
In this episode of The Science Club, Dr. Rich LaFountain delves into the intricacies of body composition and BMI, discussing his extensive research and experience in the field.
www.youtube.com/watch?v=4WD...
www.youtube.com/watch?v=4WD...
The Science of Body Composition and Longevity I The Science Club I Episode 2
In this Episode, Dr. Rich LaFountain delves into the intricacies of body composition and BMI, discussing his extensive research and experience in the field. ...
www.youtube.com
March 25, 2025 at 6:44 PM
In this episode of The Science Club, Dr. Rich LaFountain delves into the intricacies of body composition and BMI, discussing his extensive research and experience in the field.
www.youtube.com/watch?v=4WD...
www.youtube.com/watch?v=4WD...
Reposted by Daniel Tawfik
New Research Review: SGLT2 Inhibitors as Metabolic Senolytics: Clearing Senescent Cells to Combat Pathological Aging
gethealthspan.com/science/art...
gethealthspan.com/science/art...
March 9, 2025 at 3:30 PM
New Research Review: SGLT2 Inhibitors as Metabolic Senolytics: Clearing Senescent Cells to Combat Pathological Aging
gethealthspan.com/science/art...
gethealthspan.com/science/art...
Reposted by Daniel Tawfik
🧬 Why are geroscientists interested in SGLT2 inhibitors for longevity?
Approved for Type II Diabetes, these drugs differ from Metformin or Acarbose. They prevent glucose reabsorption in kidneys, leading to the excretion of 70-90g of glucose daily.
Here's why longevity researchers are intrigued. 👇
Approved for Type II Diabetes, these drugs differ from Metformin or Acarbose. They prevent glucose reabsorption in kidneys, leading to the excretion of 70-90g of glucose daily.
Here's why longevity researchers are intrigued. 👇
January 30, 2025 at 9:38 PM
🧬 Why are geroscientists interested in SGLT2 inhibitors for longevity?
Approved for Type II Diabetes, these drugs differ from Metformin or Acarbose. They prevent glucose reabsorption in kidneys, leading to the excretion of 70-90g of glucose daily.
Here's why longevity researchers are intrigued. 👇
Approved for Type II Diabetes, these drugs differ from Metformin or Acarbose. They prevent glucose reabsorption in kidneys, leading to the excretion of 70-90g of glucose daily.
Here's why longevity researchers are intrigued. 👇
Reposted by Daniel Tawfik
We often neglect the 'boring' items that matter the most:
Sleep
Eat real foods
Move mostly easy, occasionally hard.
Community & Belonging
Stress & Rest go hand in hand
Have something that:
-You can win at
-Makes you feel alive
-Expands your perspective
Sleep
Eat real foods
Move mostly easy, occasionally hard.
Community & Belonging
Stress & Rest go hand in hand
Have something that:
-You can win at
-Makes you feel alive
-Expands your perspective
January 27, 2025 at 2:40 PM
We often neglect the 'boring' items that matter the most:
Sleep
Eat real foods
Move mostly easy, occasionally hard.
Community & Belonging
Stress & Rest go hand in hand
Have something that:
-You can win at
-Makes you feel alive
-Expands your perspective
Sleep
Eat real foods
Move mostly easy, occasionally hard.
Community & Belonging
Stress & Rest go hand in hand
Have something that:
-You can win at
-Makes you feel alive
-Expands your perspective
Reposted by Daniel Tawfik
I am always shocked at the number of bizarre things people do to "optimize" their health and longevity and yet they don't exercise regularly, sleep 7-9 hours, eat fruits and veggies, build intimate bonds and community, or ever relax.
They obsess over the 0.1% but not the 99.9%.
They obsess over the 0.1% but not the 99.9%.
January 21, 2025 at 1:00 AM
I am always shocked at the number of bizarre things people do to "optimize" their health and longevity and yet they don't exercise regularly, sleep 7-9 hours, eat fruits and veggies, build intimate bonds and community, or ever relax.
They obsess over the 0.1% but not the 99.9%.
They obsess over the 0.1% but not the 99.9%.
Reposted by Daniel Tawfik
🚨 🚨 SGLT-2 Inhibitors in Aging and Healthspan: Surprising Mechanistic Insights Into Adipose Tissue Reduction, Lean Mass Preservation, and Longevity by @dantawfik and Shriya Bakhshi
hspan.io/t7CsFO
hspan.io/t7CsFO
January 19, 2025 at 5:45 PM
🚨 🚨 SGLT-2 Inhibitors in Aging and Healthspan: Surprising Mechanistic Insights Into Adipose Tissue Reduction, Lean Mass Preservation, and Longevity by @dantawfik and Shriya Bakhshi
hspan.io/t7CsFO
hspan.io/t7CsFO
Reposted by Daniel Tawfik
🚨 🚨 New Research Review: The Metabolic Basis of Neurodegeneration: The Glucose Paradox of Fueling Cognition and Driving Decline
hspan.io/lE3MqR
hspan.io/lE3MqR
December 22, 2024 at 5:18 PM
🚨 🚨 New Research Review: The Metabolic Basis of Neurodegeneration: The Glucose Paradox of Fueling Cognition and Driving Decline
hspan.io/lE3MqR
hspan.io/lE3MqR
Reposted by Daniel Tawfik
🚨🚨 New Research Review: The Role of Urolithin A in Enhancing Mitochondrial Biogenesis and Muscle Function: Mechanistic and Clinical Insights: hspan.io/l9d6jR
December 8, 2024 at 10:47 PM
🚨🚨 New Research Review: The Role of Urolithin A in Enhancing Mitochondrial Biogenesis and Muscle Function: Mechanistic and Clinical Insights: hspan.io/l9d6jR
Reposted by Daniel Tawfik
Do you share these goals? Then tell me and I'll add you to the list: go.bsky.app/E2oy2jV
December 1, 2024 at 12:39 PM
Do you share these goals? Then tell me and I'll add you to the list: go.bsky.app/E2oy2jV
Reposted by Daniel Tawfik
This story knocked the wind out of me and i hope esquire paid this man.
www.esquire.com/news-politic...
www.esquire.com/news-politic...
My Life As a Homeless Man in America
An extraordinary firsthand account.
www.esquire.com
November 28, 2024 at 10:07 PM
This story knocked the wind out of me and i hope esquire paid this man.
www.esquire.com/news-politic...
www.esquire.com/news-politic...
Reposted by Daniel Tawfik
Wonderful results: The combination of nivolumab and ipilimumab in patients with metastatic colorectal cancer led to 24-month progression-free survival of 72%, as compared with 14% with chemotherapy: nej.md/4eGp1tj
Nivolumab plus Ipilimumab in Microsatellite-Instability–High Metastatic Colorectal Cancer | NEJM
Patients with microsatellite-instability–high (MSI-H) or mismatch-repair–deficient (dMMR) metastatic colorectal cancer have poor outcomes with standard chemotherapy with or without targeted therapi...
nej.md
November 29, 2024 at 4:02 AM
Wonderful results: The combination of nivolumab and ipilimumab in patients with metastatic colorectal cancer led to 24-month progression-free survival of 72%, as compared with 14% with chemotherapy: nej.md/4eGp1tj
Reposted by Daniel Tawfik
Stress + Rest = Growth.
Stress:
•Just-manageable challenges
•Think 7 out of 10
•Ask yourself, "What is the next logical step?"
Rest:
•Switch away from primary task
•Transition out of fight-flight stress response
•Sleep (for body AND mind)
Balance these. Simple as that.
Stress:
•Just-manageable challenges
•Think 7 out of 10
•Ask yourself, "What is the next logical step?"
Rest:
•Switch away from primary task
•Transition out of fight-flight stress response
•Sleep (for body AND mind)
Balance these. Simple as that.
November 27, 2024 at 8:00 PM
Stress + Rest = Growth.
Stress:
•Just-manageable challenges
•Think 7 out of 10
•Ask yourself, "What is the next logical step?"
Rest:
•Switch away from primary task
•Transition out of fight-flight stress response
•Sleep (for body AND mind)
Balance these. Simple as that.
Stress:
•Just-manageable challenges
•Think 7 out of 10
•Ask yourself, "What is the next logical step?"
Rest:
•Switch away from primary task
•Transition out of fight-flight stress response
•Sleep (for body AND mind)
Balance these. Simple as that.
Reposted by Daniel Tawfik
New Research Review: The Surprising Role of Rapamcyin in Treating Long COVID and Post-Viral Symptoms: https://hspan.io/j5Cyvz
November 25, 2024 at 10:04 PM
New Research Review: The Surprising Role of Rapamcyin in Treating Long COVID and Post-Viral Symptoms: https://hspan.io/j5Cyvz
Protein's effects on longevity have sparked much debate.
The recently published manuscript by @michaelamrd on the pre-print server BioRxiv has compressively evaluated the role of protein intake with and without exercise.
The findings are fascinating.
Let's dive in 🧵👇
The recently published manuscript by @michaelamrd on the pre-print server BioRxiv has compressively evaluated the role of protein intake with and without exercise.
The findings are fascinating.
Let's dive in 🧵👇
November 22, 2024 at 1:00 AM
Protein's effects on longevity have sparked much debate.
The recently published manuscript by @michaelamrd on the pre-print server BioRxiv has compressively evaluated the role of protein intake with and without exercise.
The findings are fascinating.
Let's dive in 🧵👇
The recently published manuscript by @michaelamrd on the pre-print server BioRxiv has compressively evaluated the role of protein intake with and without exercise.
The findings are fascinating.
Let's dive in 🧵👇
Regular reading is a competitive advantage not simply for the accumulation of knowledge you derive from reading, but it also trains your mind to do deep-focus work. This is particularly helpful as disruptive shallow work is simultaneously training our minds to chase dopamine hits
November 19, 2024 at 9:33 PM
Regular reading is a competitive advantage not simply for the accumulation of knowledge you derive from reading, but it also trains your mind to do deep-focus work. This is particularly helpful as disruptive shallow work is simultaneously training our minds to chase dopamine hits
Evaluating mitochondrial function begins with two key parameters: the ability of a compound to boost ATP production and its capacity to reduce oxidative stress.
This week, we apply this framework to Urolithin A, a gut-derived metabolite known to enhance mitophagy
gethealthspan.com/science/arti...
This week, we apply this framework to Urolithin A, a gut-derived metabolite known to enhance mitophagy
gethealthspan.com/science/arti...
Healthspan Research Review | The Science of Mitophagy: Urolithin A’s Impact on Mitochondrial Function and Aging
Urolithin A (UA), a metabolite derived from dietary polyphenols by the gut microbiota, has emerged as a pivotal molecule in the pursuit of healthy aging due to its ability to enhance mitochondrial fun...
gethealthspan.com
November 18, 2024 at 12:48 AM
Evaluating mitochondrial function begins with two key parameters: the ability of a compound to boost ATP production and its capacity to reduce oxidative stress.
This week, we apply this framework to Urolithin A, a gut-derived metabolite known to enhance mitophagy
gethealthspan.com/science/arti...
This week, we apply this framework to Urolithin A, a gut-derived metabolite known to enhance mitophagy
gethealthspan.com/science/arti...
Oxytocin: The Unexpected Neuroprotective Molecule Targeting Brain Aging and Enhancing Cognitive Health
Beyond its role in social bonding, recent research suggests that oxytocin may play a pivotal role in protecting the brain from age-related decline.
gethealthspan.com/science/arti...
Beyond its role in social bonding, recent research suggests that oxytocin may play a pivotal role in protecting the brain from age-related decline.
gethealthspan.com/science/arti...
Healthspan Research Review | Oxytocin: The Unexpected Neuroprotective Molecule Targeting Brain Aging and Enhancing Cognitive Health
Oxytocin, traditionally recognized for its roles in reproduction and social bonding, is emerging as a promising neuroprotective agent with potential implications for brain health and resilience. Recen...
gethealthspan.com
November 16, 2024 at 7:27 PM
Oxytocin: The Unexpected Neuroprotective Molecule Targeting Brain Aging and Enhancing Cognitive Health
Beyond its role in social bonding, recent research suggests that oxytocin may play a pivotal role in protecting the brain from age-related decline.
gethealthspan.com/science/arti...
Beyond its role in social bonding, recent research suggests that oxytocin may play a pivotal role in protecting the brain from age-related decline.
gethealthspan.com/science/arti...