BDM is pervasive in development but difficult to understand due to the necessity of incorporating multiple tissue deformations in their global context. We absorb these into simple and measurable parameters and provide both a model and model system to understand boundary-driven morphogenesis. (8/8)

We then acquired a light sheet dataset and tracked each nucleus within the hindgut (~40,000 annotations for one embryo!) as it deformed. We constructed closed space curves, or "contours," that follow the movements of nuclei and mirror the minimal model's representation of the tissue. (5/8)

A ring of cells deforms into a triangular keyhole in just 15 minutes. Meet the hindgut, a model for boundary-driven morphogenesis!

Out now in @pnas.org at doi.org/10.1073/pnas... with @zhaoshh.bsky.social, Alex Jacinto, Eric Wieschaus, Stas Shvartsman, @lepuslapis.bsky.social (1/8)