Dan Jones
@daniel-jones.bsky.social
Research Associate in the Blacklow Lab at Harvard Medical School. Study mechanisms of protein adhesion and signalling using Cryo-EM.
Earlier this year we published functional profiles of all 33 adhesion GPCRs in signalling/biosensor assays. Led by recently graduated Drew Dates, we found a dichotomy of tethered agonist dependent and independent receptors.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
November 17, 2024 at 8:14 PM
Earlier this year we published functional profiles of all 33 adhesion GPCRs in signalling/biosensor assays. Led by recently graduated Drew Dates, we found a dichotomy of tethered agonist dependent and independent receptors.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Our recent story on the mechanism of PP2A/B55 inhibition by IER5 - a notch target gene essential for keratinocyte differentiation in squamous cell carcinoma cells. We use functional assays, biochemistry and Cryo-EM to determine the molecular mechanism www.biorxiv.org/content/10.1...
November 17, 2024 at 8:03 PM
Our recent story on the mechanism of PP2A/B55 inhibition by IER5 - a notch target gene essential for keratinocyte differentiation in squamous cell carcinoma cells. We use functional assays, biochemistry and Cryo-EM to determine the molecular mechanism www.biorxiv.org/content/10.1...