Daniel L. Barber, PhD
LightNews LightNews
banner
danbarberphd.bsky.social
Daniel L. Barber, PhD
@danbarberphd.bsky.social
2.3K followers 270 following 9 posts
Immunologist. Major focus is on T cell responses to Mycobacterium tuberculosis infection.
Posts Replies Media Videos
danbarberphd.bsky.social
Congrats Chuck!!!
December 8, 2024 at 12:17 AM
Reposted by Daniel L. Barber, PhD
pauljbaker.bsky.social
Thanks to all of our amazing coauthors including @kerryhilligan.bsky.social, @danbarberphd.bsky.social for spending many, many hours tolerating me in the BSL3 lab, helping with experiments and data analysis, and providing valuable advice and moral support!
December 7, 2024 at 11:47 PM
Reposted by Daniel L. Barber, PhD
pauljbaker.bsky.social
More details in this 🧵 from my powerhouse PI @mayerbarber.bsky.social whose foresight and guidance got us to this fantastic manuscript!
mayerbarber.bsky.social Kat Mayer-Barber,PhD @mayerbarber.bsky.social · Dec 6
Best #Nikolaus 🎅! Our paper on how the 🫁 microenvironment can shape #innate immunity against #viruses is out @sciimmunology.bsky.social This was a herculean effort brilliantly led by @pauljbaker.bsky.social who singlehandedly established the model in the lab during the pandemic. 🧪 #Immunosky 1/9
Graphical summary of our paper. In mice, prior lower airway exposure to diverse inflammatory stimuli, including chronic bacterial infections such as M. tuberculosis, acute bacterial infections such as pulmonary S. aureus, viral infections such as Influenza A, type-II allergic responses such as the OVA-Alum model, activation of pulmonary TLR9 by CpG or pulmonary TLR1/2 by Pam3CSK4 leads to reduced viral burden upon subsequent infection with SARS-CoV-2 (SCV2). (2) This SCV2 restriction occurs prior to induction of SCV2-specific adaptive immune responses and is mediated through innate immune responses, including the induction of IFN-I, TNFα and IL-1 and sustained changes to the TRM (Tissue resident macrophage) cellular compartment and the pulmonary epithelium. (3) Innate cytokine and TLR signaling to both recruited immune cells and the pulmonary epithelium creates a microenvironment in the lung that limits early replication of SCV2. IFN-I signaling to pulmonary ECs (epithelial cells) increases expression of interferon-stimulated genes, that likely cell-intrinsically limit viral replication. TNF- or IL-1 suppress SCV2 independently of IFN-I signaling. TNF acts exclusively through radio-resistant cell types such as the lung epithelium, whereas IL-1 affords control both direct and indirectly, through either stromal and hematopoietic cell types, to restrict overall early SCV2 burden.
December 7, 2024 at 11:47 PM
Reposted by Daniel L. Barber, PhD
mayerbarber.bsky.social
🙏 to @niaidnews.bsky.social, first author @pauljbaker.bsky.social and my amazing lab team, our collaborators @kerryhilligan.bsky.social @danbarberphd.bsky.social 🙏to editor extraordinaire @hannah-isles.bsky.social and the reviewers who guided us along the way 9/9
www.science.org/doi/10.1126/...
The inflammatory microenvironment of the lung at the time of infection governs innate control of SARS-CoV-2 replication
Recent or ongoing respiratory inflammation in the lung regulates antiviral immune responses to SARS-CoV-2.
www.science.org
December 6, 2024 at 10:38 PM
danbarberphd.bsky.social
Please add me.
November 19, 2024 at 12:12 AM
danbarberphd.bsky.social
Please add me.
November 18, 2024 at 10:30 AM
danbarberphd.bsky.social
Please add me.
November 17, 2024 at 10:26 AM
danbarberphd.bsky.social
Great! Thanks. Still trying to figure out how this works here.
November 11, 2024 at 12:10 AM
danbarberphd.bsky.social
Hi Madhu - my lab is in the NIH/NIAID intramural program and we study T cell responses to #tuberculosis.
November 10, 2024 at 11:02 PM