Damián García-García
@damgargar.bsky.social
Ph.D student working with axolotls.
(@mdibiolab / @murawalalab )
Interested in Developmental Biology and Regeneration.
(@mdibiolab / @murawalalab )
Interested in Developmental Biology and Regeneration.
I want to thank my Ph.D. mentor, @murawalalab.bsky.social, and all the co-authors in the manuscript. Without their work, this project wouldn’t be a reality! 🫶
Let us know what you think 😀
Let us know what you think 😀
April 3, 2025 at 8:01 PM
I want to thank my Ph.D. mentor, @murawalalab.bsky.social, and all the co-authors in the manuscript. Without their work, this project wouldn’t be a reality! 🫶
Let us know what you think 😀
Let us know what you think 😀
With this
• We conclude that CT cells are the majority of blastema cells and are necessary for axolotl limb regeneration
• Establish a cell ablation system in the axolotl that can be combined with any Cre-specific line
• Provide a new database of the dynamics in CT cells expression over time
• We conclude that CT cells are the majority of blastema cells and are necessary for axolotl limb regeneration
• Establish a cell ablation system in the axolotl that can be combined with any Cre-specific line
• Provide a new database of the dynamics in CT cells expression over time
April 3, 2025 at 8:01 PM
With this
• We conclude that CT cells are the majority of blastema cells and are necessary for axolotl limb regeneration
• Establish a cell ablation system in the axolotl that can be combined with any Cre-specific line
• Provide a new database of the dynamics in CT cells expression over time
• We conclude that CT cells are the majority of blastema cells and are necessary for axolotl limb regeneration
• Establish a cell ablation system in the axolotl that can be combined with any Cre-specific line
• Provide a new database of the dynamics in CT cells expression over time
Given their importance, we characterized the molecular dynamics of CT cells over time and deposited this database into an interactive web platform 💻(microarrayct-murawalalab.mdibl.org)
Murawala Agilent Axo Gene Expression
microarrayct-murawalalab.mdibl.org
April 3, 2025 at 8:01 PM
Given their importance, we characterized the molecular dynamics of CT cells over time and deposited this database into an interactive web platform 💻(microarrayct-murawalalab.mdibl.org)
We then eliminated CT cells by using the NTR/MTZ #ablation system. After the specific elimination of CT cells, limb regeneration was delayed or truncated, underscoring the necessity of these cells for #regeneration 🤯
April 3, 2025 at 8:01 PM
We then eliminated CT cells by using the NTR/MTZ #ablation system. After the specific elimination of CT cells, limb regeneration was delayed or truncated, underscoring the necessity of these cells for #regeneration 🤯
We defined the dynamic changes of cellular identities within the blastema over time by using 10X #Xenium spatial transcriptomics. Immune cells predominate in the first stages, whereas CT cells gradually increment and become the predominant cell type (~73%) at the late-bud blastema stage 🤔.
April 3, 2025 at 8:01 PM
We defined the dynamic changes of cellular identities within the blastema over time by using 10X #Xenium spatial transcriptomics. Immune cells predominate in the first stages, whereas CT cells gradually increment and become the predominant cell type (~73%) at the late-bud blastema stage 🤔.