Carlos Sanchez Cano
@csc-xibl.bsky.social
X-rays for Inorganic Biochemistry, and a dash of Tuna
New paper at @chemcomm.rsc.org with @lsalassa.bsky.social and I14 at @diamondlightsource.bsky.social
X-ray spectromicroscopy shows that conjugating flavins to PtIV prodrugs improve greatly activation efficiency, even at much lower irradiation dose!
@dipcehu.bsky.social
doi.org/10.1039/D5CC...
X-ray spectromicroscopy shows that conjugating flavins to PtIV prodrugs improve greatly activation efficiency, even at much lower irradiation dose!
@dipcehu.bsky.social
doi.org/10.1039/D5CC...
October 27, 2025 at 9:43 AM
New paper at @chemcomm.rsc.org with @lsalassa.bsky.social and I14 at @diamondlightsource.bsky.social
X-ray spectromicroscopy shows that conjugating flavins to PtIV prodrugs improve greatly activation efficiency, even at much lower irradiation dose!
@dipcehu.bsky.social
doi.org/10.1039/D5CC...
X-ray spectromicroscopy shows that conjugating flavins to PtIV prodrugs improve greatly activation efficiency, even at much lower irradiation dose!
@dipcehu.bsky.social
doi.org/10.1039/D5CC...
Will be opening soon a position for a PhD student at the DIPC.
The student would use X-ray imaging or spectroscopic techniques to probe metallodrugs during biological dynamic processes
Contact me (carlos.sanchez@dipc.org) for more information, attaching a CV and a brief statement of interest.
The student would use X-ray imaging or spectroscopic techniques to probe metallodrugs during biological dynamic processes
Contact me (carlos.sanchez@dipc.org) for more information, attaching a CV and a brief statement of interest.
September 15, 2025 at 11:32 AM
Will be opening soon a position for a PhD student at the DIPC.
The student would use X-ray imaging or spectroscopic techniques to probe metallodrugs during biological dynamic processes
Contact me (carlos.sanchez@dipc.org) for more information, attaching a CV and a brief statement of interest.
The student would use X-ray imaging or spectroscopic techniques to probe metallodrugs during biological dynamic processes
Contact me (carlos.sanchez@dipc.org) for more information, attaching a CV and a brief statement of interest.
Reposted by Carlos Sanchez Cano
A gold nanoparticle may start out as a neatly engineered sphere with a protective coating. But the moment it encounters blood or tissue fluid, proteins, fats, and sugars begin to stick to it.
https://mappingignorance.org/2025/08/07/x-rays-reveal-the-true-identity-of-nanoparticles-in-medicine/
https://mappingignorance.org/2025/08/07/x-rays-reveal-the-true-identity-of-nanoparticles-in-medicine/
August 8, 2025 at 2:05 AM
A gold nanoparticle may start out as a neatly engineered sphere with a protective coating. But the moment it encounters blood or tissue fluid, proteins, fats, and sugars begin to stick to it.
https://mappingignorance.org/2025/08/07/x-rays-reveal-the-true-identity-of-nanoparticles-in-medicine/
https://mappingignorance.org/2025/08/07/x-rays-reveal-the-true-identity-of-nanoparticles-in-medicine/
Reposted by Carlos Sanchez Cano
The difficulty lies in the fact that once nanoparticles enter the human body, they rarely remain in the form in which they were designed.
ASAXS reveals the true identity of nanoparticles in medicine
How anomalous small‑angle X‑ray scattering (ASAXS) uncover the hidden layers that shape nanomedicine therapies
mappingignorance.org
August 8, 2025 at 12:05 AM
The difficulty lies in the fact that once nanoparticles enter the human body, they rarely remain in the form in which they were designed.
Reposted by Carlos Sanchez Cano
Nanoparticles are not just tiny tools; they are dynamic players in a complex biological game. Thanks to advanced X‑ray methods, we are finally learning the rules.
ASAXS reveals the true identity of nanoparticles in medicine
How anomalous small‑angle X‑ray scattering (ASAXS) uncover the hidden layers that shape nanomedicine therapies
mappingignorance.org
August 7, 2025 at 7:05 PM
Nanoparticles are not just tiny tools; they are dynamic players in a complex biological game. Thanks to advanced X‑ray methods, we are finally learning the rules.
Reposted by Carlos Sanchez Cano
This article breaks down the findings, exploring why size matters, how spheroids serve as testing grounds, and what lies ahead for nanoparticle research.
https://mappingignorance.org/2025/06/19/how-tiny-particles-navigate-tumours-understanding-nanoparticle-penetration-in-3d-cell-models/
https://mappingignorance.org/2025/06/19/how-tiny-particles-navigate-tumours-understanding-nanoparticle-penetration-in-3d-cell-models/
June 19, 2025 at 7:05 PM
This article breaks down the findings, exploring why size matters, how spheroids serve as testing grounds, and what lies ahead for nanoparticle research.
https://mappingignorance.org/2025/06/19/how-tiny-particles-navigate-tumours-understanding-nanoparticle-penetration-in-3d-cell-models/
https://mappingignorance.org/2025/06/19/how-tiny-particles-navigate-tumours-understanding-nanoparticle-penetration-in-3d-cell-models/
Reposted by Carlos Sanchez Cano
By testing gold nanoparticles, using sophisticated imaging techniques, the study reveals critical insights into designing nanoparticles for effective cancer therapy.
https://mappingignorance.org/2025/06/19/how-tiny-particles-navigate-tumours-understanding-nanoparticle-penetration-in-3d-cell-models/
https://mappingignorance.org/2025/06/19/how-tiny-particles-navigate-tumours-understanding-nanoparticle-penetration-in-3d-cell-models/
June 20, 2025 at 2:05 AM
By testing gold nanoparticles, using sophisticated imaging techniques, the study reveals critical insights into designing nanoparticles for effective cancer therapy.
https://mappingignorance.org/2025/06/19/how-tiny-particles-navigate-tumours-understanding-nanoparticle-penetration-in-3d-cell-models/
https://mappingignorance.org/2025/06/19/how-tiny-particles-navigate-tumours-understanding-nanoparticle-penetration-in-3d-cell-models/
Reposted by Carlos Sanchez Cano
This article breaks down the findings, exploring why size matters, how spheroids serve as testing grounds, and what lies ahead for nanoparticle research.
https://mappingignorance.org/2025/06/19/how-tiny-particles-navigate-tumours-understanding-nanoparticle-penetration-in-3d-cell-models/
https://mappingignorance.org/2025/06/19/how-tiny-particles-navigate-tumours-understanding-nanoparticle-penetration-in-3d-cell-models/
June 20, 2025 at 4:05 AM
This article breaks down the findings, exploring why size matters, how spheroids serve as testing grounds, and what lies ahead for nanoparticle research.
https://mappingignorance.org/2025/06/19/how-tiny-particles-navigate-tumours-understanding-nanoparticle-penetration-in-3d-cell-models/
https://mappingignorance.org/2025/06/19/how-tiny-particles-navigate-tumours-understanding-nanoparticle-penetration-in-3d-cell-models/
Reposted by Carlos Sanchez Cano
A new review examines how nanoparticle size influences their ability to penetrate 3D tumour spheroids—simplified models that mimic real tumours.
Understanding nanoparticle penetration in 3D cell models
Nanoparticles, those minuscule marvels measured in billionths of a metre, hold immense promise for revolutionizing cancer treatment. Their ability to deliver drugs directly to tumours could transform therapies, but only if they can navigate the dense, complex environment of tumour tissue. A new review , that includes a new experimental data set, explores this challenge, […]
mappingignorance.org
June 20, 2025 at 12:05 AM
A new review examines how nanoparticle size influences their ability to penetrate 3D tumour spheroids—simplified models that mimic real tumours.
Very proud of this in #SMALL. Working with Marvin Skiba from the Parak group at #CHyN in Hamburg and P62 beamline at #DESY
Using Anomalous SAXS to study separately each of the individual components of metal NPs and the protein corona around!
@dipcehu.bsky.social
doi.org/10.1002/smll...
Using Anomalous SAXS to study separately each of the individual components of metal NPs and the protein corona around!
@dipcehu.bsky.social
doi.org/10.1002/smll...
doi.org
June 11, 2025 at 8:22 AM
Very proud of this in #SMALL. Working with Marvin Skiba from the Parak group at #CHyN in Hamburg and P62 beamline at #DESY
Using Anomalous SAXS to study separately each of the individual components of metal NPs and the protein corona around!
@dipcehu.bsky.social
doi.org/10.1002/smll...
Using Anomalous SAXS to study separately each of the individual components of metal NPs and the protein corona around!
@dipcehu.bsky.social
doi.org/10.1002/smll...
Good to see this out in #AdvancedDrugDeliveryReviews. Great work with the Parak group from #CHyN in Hamburg and P06 beamline at #DESY
Have a look to see how different imaging techniques compare for the study of nanoparticle penetration in spheroids!
@dipcehu.bsky.social
doi.org/10.1016/j.ad...
Have a look to see how different imaging techniques compare for the study of nanoparticle penetration in spheroids!
@dipcehu.bsky.social
doi.org/10.1016/j.ad...
Redirecting
kwnsfk27.r.eu-west-1.awstrack.me
May 12, 2025 at 9:20 AM
Good to see this out in #AdvancedDrugDeliveryReviews. Great work with the Parak group from #CHyN in Hamburg and P06 beamline at #DESY
Have a look to see how different imaging techniques compare for the study of nanoparticle penetration in spheroids!
@dipcehu.bsky.social
doi.org/10.1016/j.ad...
Have a look to see how different imaging techniques compare for the study of nanoparticle penetration in spheroids!
@dipcehu.bsky.social
doi.org/10.1016/j.ad...
Reposted by Carlos Sanchez Cano
X-ray fluorescence imaging, a pivotal tool in modern biological research.
By @dipcehu.bsky.social
https://mappingignorance.org/2025/03/20/x-ray-fluorescence-imaging-a-pivotal-tool-in-modern-biological-research/
By @dipcehu.bsky.social
https://mappingignorance.org/2025/03/20/x-ray-fluorescence-imaging-a-pivotal-tool-in-modern-biological-research/
March 20, 2025 at 2:02 PM
X-ray fluorescence imaging, a pivotal tool in modern biological research.
By @dipcehu.bsky.social
https://mappingignorance.org/2025/03/20/x-ray-fluorescence-imaging-a-pivotal-tool-in-modern-biological-research/
By @dipcehu.bsky.social
https://mappingignorance.org/2025/03/20/x-ray-fluorescence-imaging-a-pivotal-tool-in-modern-biological-research/
Reposted by Carlos Sanchez Cano
In a study, researchers investigated the use of biodegradable polyelectrolyte capsules as carriers for selenium compounds.
https://mappingignorance.org/2025/03/20/x-ray-fluorescence-imaging-a-pivotal-tool-in-modern-biological-research/
https://mappingignorance.org/2025/03/20/x-ray-fluorescence-imaging-a-pivotal-tool-in-modern-biological-research/
March 21, 2025 at 5:05 AM
In a study, researchers investigated the use of biodegradable polyelectrolyte capsules as carriers for selenium compounds.
https://mappingignorance.org/2025/03/20/x-ray-fluorescence-imaging-a-pivotal-tool-in-modern-biological-research/
https://mappingignorance.org/2025/03/20/x-ray-fluorescence-imaging-a-pivotal-tool-in-modern-biological-research/
Final one of 2024 at @jsynchrotronrad.iucr.org
Need a free 3D printed cryo-transporter of silicon nitride membranes? Tested at @esrf.fr @diamondlightsource.bsky.social #desy
Done with Antonio Dominguez-Alfaro around some #papasconchocos and #cruzcampo
@dipcehu.bsky.social
doi.org/10.1107/S160...
Need a free 3D printed cryo-transporter of silicon nitride membranes? Tested at @esrf.fr @diamondlightsource.bsky.social #desy
Done with Antonio Dominguez-Alfaro around some #papasconchocos and #cruzcampo
@dipcehu.bsky.social
doi.org/10.1107/S160...
3DCryoHolder: a new open access 3D printable system to store and transport silicon nitride membranes under cryogenic conditions for spectromicroscopy at low temperature
A system (3DCryoHolder) has been developed to store and transport silicon nitride membranes under cryogenic conditions for X-ray spectromicroscopy measurements at synchrotron research facilities. The ...
doi.org
December 18, 2024 at 9:08 AM
Final one of 2024 at @jsynchrotronrad.iucr.org
Need a free 3D printed cryo-transporter of silicon nitride membranes? Tested at @esrf.fr @diamondlightsource.bsky.social #desy
Done with Antonio Dominguez-Alfaro around some #papasconchocos and #cruzcampo
@dipcehu.bsky.social
doi.org/10.1107/S160...
Need a free 3D printed cryo-transporter of silicon nitride membranes? Tested at @esrf.fr @diamondlightsource.bsky.social #desy
Done with Antonio Dominguez-Alfaro around some #papasconchocos and #cruzcampo
@dipcehu.bsky.social
doi.org/10.1107/S160...
Good to see this out in #ChemicalScience, it was coming for a while. Great work with Fernando Lopez-Gallego and Javier Santiago from #CICbiomaGUNE at the #esrf
Have a look to see how we use X-rays to study the exhaustion of biocatalysts!
@dipcehu.bsky.social
pubs.rsc.org/en/content/a...
Have a look to see how we use X-rays to study the exhaustion of biocatalysts!
@dipcehu.bsky.social
pubs.rsc.org/en/content/a...
Unveiling the spatial rearrangements of exhausted immobilised multi-enzyme systems through cryo-X-ray fluorescence nanoprobe imaging
Enzyme immobilisation is of great importance for the fabrication of heterogeneous biocatalysts, as it allows the stabilisation of proteins using a solid support. Moreover, it permits their reuse in co...
pubs.rsc.org
November 25, 2024 at 9:41 AM
Good to see this out in #ChemicalScience, it was coming for a while. Great work with Fernando Lopez-Gallego and Javier Santiago from #CICbiomaGUNE at the #esrf
Have a look to see how we use X-rays to study the exhaustion of biocatalysts!
@dipcehu.bsky.social
pubs.rsc.org/en/content/a...
Have a look to see how we use X-rays to study the exhaustion of biocatalysts!
@dipcehu.bsky.social
pubs.rsc.org/en/content/a...