Jake Smith
@cryingem.bsky.social
PFIB-tamer, tissue lifter-outerer, stage-tilter, electron advocate, neuron fan
Oxford/RFI - Grange Lab🔬
Oxford/RFI - Grange Lab🔬
if you have to do MFA twice in the same "day": go to bed
September 30, 2025 at 1:09 AM
if you have to do MFA twice in the same "day": go to bed
Reposted by Jake Smith
Lokiarchaea are tricky to work with in the lab: they grow very slowly, exclusively in an oxygen free environment with the presence of symbiotic bacteria. But with careful nurturing, scientists hope to witness their cell division at work.
Tiny Tubes Reveal Clues to the Evolution of Complex Life | Quanta Magazine
Scientists have identified tubulin structures in primitive Asgard archea that may have been the precursor of our own cellular skeletons.
www.quantamagazine.org
September 10, 2025 at 3:46 PM
Lokiarchaea are tricky to work with in the lab: they grow very slowly, exclusively in an oxygen free environment with the presence of symbiotic bacteria. But with careful nurturing, scientists hope to witness their cell division at work.
August 31, 2025 at 3:38 PM
hot (well, cold) off the press! ❄️
well done @glynnca.bsky.social & @michaelgrange.bsky.social & fabulous co-authors 👏🏼
#teamtomo #cryoET
well done @glynnca.bsky.social & @michaelgrange.bsky.social & fabulous co-authors 👏🏼
#teamtomo #cryoET
July 21, 2025 at 8:55 PM
hot (well, cold) off the press! ❄️
well done @glynnca.bsky.social & @michaelgrange.bsky.social & fabulous co-authors 👏🏼
#teamtomo #cryoET
well done @glynnca.bsky.social & @michaelgrange.bsky.social & fabulous co-authors 👏🏼
#teamtomo #cryoET
Delighted to see our work in press! 🙌🔬🧠
Thanks to @glynnca.bsky.social, @michaelgrange.bsky.social and the rest of the fabulous co-authors for all your contributions.
Excited to see where in tissue structural cell biology goes next 👀!
#liftlaughlove #teamtomo #whopper
Thanks to @glynnca.bsky.social, @michaelgrange.bsky.social and the rest of the fabulous co-authors for all your contributions.
Excited to see where in tissue structural cell biology goes next 👀!
#liftlaughlove #teamtomo #whopper
Proud to share our latest paper. doi.org/10.1016/j.cr...
Through the dedication of @glynnca.bsky.social and @cryingem.bsky.social we report a thorough method to image molecular organisation within hippocampus tissue.
Structural biology in tissue is well and truly here!
@rosfrankinst.bsky.social
Through the dedication of @glynnca.bsky.social and @cryingem.bsky.social we report a thorough method to image molecular organisation within hippocampus tissue.
Structural biology in tissue is well and truly here!
@rosfrankinst.bsky.social
June 19, 2025 at 9:23 AM
Delighted to see our work in press! 🙌🔬🧠
Thanks to @glynnca.bsky.social, @michaelgrange.bsky.social and the rest of the fabulous co-authors for all your contributions.
Excited to see where in tissue structural cell biology goes next 👀!
#liftlaughlove #teamtomo #whopper
Thanks to @glynnca.bsky.social, @michaelgrange.bsky.social and the rest of the fabulous co-authors for all your contributions.
Excited to see where in tissue structural cell biology goes next 👀!
#liftlaughlove #teamtomo #whopper
April 25, 2025 at 6:31 PM
note to self: don't turn out of office replies on
April 22, 2025 at 5:27 PM
note to self: don't turn out of office replies on
Reposted by Jake Smith
Exploring shaped focused ion beams for lamella preparation https://www.biorxiv.org/content/10.1101/2025.04.01.646235v1
April 6, 2025 at 10:47 PM
Exploring shaped focused ion beams for lamella preparation https://www.biorxiv.org/content/10.1101/2025.04.01.646235v1
Reposted by Jake Smith
Check out our paper on Xenon milling of HPF samples, now online @naturecomms.bsky.social
rdcu.be/eczIb
rdcu.be/eczIb
rdcu.be
March 7, 2025 at 12:54 PM
Check out our paper on Xenon milling of HPF samples, now online @naturecomms.bsky.social
rdcu.be/eczIb
rdcu.be/eczIb
Barista: How caffeinated would you like to be?
Me: Yes
Me: Yes
March 5, 2025 at 11:51 AM
Barista: How caffeinated would you like to be?
Me: Yes
Me: Yes
Reposted by Jake Smith
Isolated in just 3 years! (previously, 12 years). We obtained two strains from 'Hodarchaeales', proposed to be closest to our archaeal ancestor. Our analysis suggests the ancestor was an anaerobic, syntrophic, peptidotrophic, archaeon with a simple intracellular structure and possible aerotolerance.
Eukaryotes' closest relatives are internally simple syntrophic archaea
Eukaryotes are theorized to have originated from an archaeal phylum Promethearchaeota (formerly 'Asgard' archaea)1,2. The first cultured representatives revealed valuable insight3,4 but are distantly ...
www.biorxiv.org
February 27, 2025 at 3:58 AM
Isolated in just 3 years! (previously, 12 years). We obtained two strains from 'Hodarchaeales', proposed to be closest to our archaeal ancestor. Our analysis suggests the ancestor was an anaerobic, syntrophic, peptidotrophic, archaeon with a simple intracellular structure and possible aerotolerance.
A great opportunity! (especially to hear @glynnca.bsky.social spread the plasma gospel🙌🏻)
Thanks to Instruct-ERIC, the @embl.org Imaging Centre is able to offer an advanced hands-on workshop on cryo-FIB-SEM methods. This is a great opportunity to exchange knowledge with our fantastic cryo-CLEM specialists! 21-25 July 2025. Apply here before May 12th: www.embl.org/about/info/i...
February 22, 2025 at 1:54 PM
A great opportunity! (especially to hear @glynnca.bsky.social spread the plasma gospel🙌🏻)
Congrats Charlie & co.! The use of optogenetics for in tissue CLEM here is really elegant.
Memory engram synapse 3D molecular architecture visualized by cryoCLEM-guided cryoET pubmed.ncbi.nlm.nih.gov/39829918/
January 22, 2025 at 12:58 PM
Congrats Charlie & co.! The use of optogenetics for in tissue CLEM here is really elegant.
Reposted by Jake Smith
A long read from 2017 but well worth the time for any scientist who both loves their job and and often finds themselves questioning their life decisions. www.danielnettle.org.uk/wp-content/u...
www.danielnettle.org.uk
December 8, 2024 at 10:05 PM
A long read from 2017 but well worth the time for any scientist who both loves their job and and often finds themselves questioning their life decisions. www.danielnettle.org.uk/wp-content/u...
Reposted by Jake Smith
We have quite a range of PhD projects this year, covering cryo-EM methods, bacteriology/bioenergetics, and infection/antibiotics/vaccines. Would really appreciate if people can RT and share with their teams!
November 29, 2024 at 11:55 AM
We have quite a range of PhD projects this year, covering cryo-EM methods, bacteriology/bioenergetics, and infection/antibiotics/vaccines. Would really appreciate if people can RT and share with their teams!
Reposted by Jake Smith
Is there such thing as TEMTuesday? Maybe CryoETuesday? Myelinated axon cross section with microtubules and intermediate filaments:
November 26, 2024 at 6:50 PM
Is there such thing as TEMTuesday? Maybe CryoETuesday? Myelinated axon cross section with microtubules and intermediate filaments:
it is nicer over here
November 15, 2024 at 9:20 PM
it is nicer over here