5/ Indeed!
Stress measurements (in vivo & in vitro) show a correlation between compression and Lgr5. With
Jochen's Guck Lab
.
To test causality, we physically confined organoids and tumors — and confinement alone was sufficient to boost stemness! With
Julie Guillermet Lab

1/ 🎉Excited to share our new preprint @vignjeviclab.bsky.social @davidbrueckner.bsky.social :

"Self-organization of tumor heterogeneity and plasticity"
biorxiv.org/content/10.1...

Tumor heterogeneity and plasticity drive metastasis and relapse. How is tumor patterning coordinated?

A thread👇