Coscia Lab
@coscialab.bsky.social
...we are passionate about spatial proteomics, mass spectrometry and single-cell technologies to study disease mechanisms @MDC_Berlin 🇩🇪🇨🇴🇨🇳🇰🇿🇵🇷🇵🇱🇲🇽
Check out our latest preprint in collaboration with the @garyrlewin.bsky.social lab! We obtained the first subset-specific proteomes of pain sensing neurons!
We present the first subset-specific proteomic signature of electrophysiologically-defined, pain-sensing neurons. One step closer to uniting function with molecules- one neuron at a time. Thanks to all who have contributed, especially @coscialab.bsky.social @garyrlewin.bsky.social #neuroscience
Ultrasensitive proteomics uncovers nociceptor diversity and novel pain targets https://www.biorxiv.org/content/10.1101/2025.09.20.677124v1
September 22, 2025 at 6:17 PM
Check out our latest preprint in collaboration with the @garyrlewin.bsky.social lab! We obtained the first subset-specific proteomes of pain sensing neurons!
Excited to introduce openDVP — an open-source framework to bring deep visual proteomics to the broader research community! It includes:
– A simplified fast-track pipeline for easy adoption
– An AI-powered option for advanced image & spatial analysis
👉 BioRxiv: bit.ly/44SBuHu
👉 Github: bit.ly/4eR3IqK
– A simplified fast-track pipeline for easy adoption
– An AI-powered option for advanced image & spatial analysis
👉 BioRxiv: bit.ly/44SBuHu
👉 Github: bit.ly/4eR3IqK
July 17, 2025 at 11:09 AM
Excited to introduce openDVP — an open-source framework to bring deep visual proteomics to the broader research community! It includes:
– A simplified fast-track pipeline for easy adoption
– An AI-powered option for advanced image & spatial analysis
👉 BioRxiv: bit.ly/44SBuHu
👉 Github: bit.ly/4eR3IqK
– A simplified fast-track pipeline for easy adoption
– An AI-powered option for advanced image & spatial analysis
👉 BioRxiv: bit.ly/44SBuHu
👉 Github: bit.ly/4eR3IqK
Thrilled to share our latest preprint describing an optimized spatial tissue proteomics workflow for the preparation and analysis of >100 proteomes / day at high spatial resolution.
Kudos to @melissaklingeberg.bsky.social 🥳 and big thanks to all our collaborators! bit.ly/3SCARw4
Kudos to @melissaklingeberg.bsky.social 🥳 and big thanks to all our collaborators! bit.ly/3SCARw4
An ultrasensitive spatial tissue proteomics workflow exceeding 100 proteomes per day
Achieving high-resolution spatial tissue proteomes requires careful balancing and integration of optimized sample processing, chromatography, and MS acquisition. Here, we present an advanced cellenONE...
bit.ly
June 5, 2025 at 5:57 PM
Thrilled to share our latest preprint describing an optimized spatial tissue proteomics workflow for the preparation and analysis of >100 proteomes / day at high spatial resolution.
Kudos to @melissaklingeberg.bsky.social 🥳 and big thanks to all our collaborators! bit.ly/3SCARw4
Kudos to @melissaklingeberg.bsky.social 🥳 and big thanks to all our collaborators! bit.ly/3SCARw4
Our lab's newest preprint is out on deep spatial proteomics of ovarian cancer precursor lesions!
We demonstrate how ultrasensitive discovery proteomics can shed light onto early carcinogenesis, uncover cell-of-origin signatures, and prioritize novel drug targets.
bit.ly/41M7fke
We demonstrate how ultrasensitive discovery proteomics can shed light onto early carcinogenesis, uncover cell-of-origin signatures, and prioritize novel drug targets.
bit.ly/41M7fke
Deep spatial proteomics of ovarian cancer precursor lesions delineates early disease changes and cell-of-origin signatures
High-grade serous ovarian cancer (HGSOC) is a devastating disease that is frequently detected at an advanced and incurable stage. Advances in ultrasensitive mass spectrometry-based spatial proteomics ...
www.biorxiv.org
March 20, 2025 at 8:59 AM
Our lab's newest preprint is out on deep spatial proteomics of ovarian cancer precursor lesions!
We demonstrate how ultrasensitive discovery proteomics can shed light onto early carcinogenesis, uncover cell-of-origin signatures, and prioritize novel drug targets.
bit.ly/41M7fke
We demonstrate how ultrasensitive discovery proteomics can shed light onto early carcinogenesis, uncover cell-of-origin signatures, and prioritize novel drug targets.
bit.ly/41M7fke
Reposted by Coscia Lab
Shout out to the organisers @jesperolsenlab.bsky.social, (Tina Ludwig) @baybioms.bsky.social kathrynslilley.bsky.social, Caroline May and Britta Eggers
and the speakers @bonalditiziana.bsky.social, @coscialab.bsky.social, @kusterlab.bsky.social, @anamdv.bsky.social, @jsandow.bsky.social
and the speakers @bonalditiziana.bsky.social, @coscialab.bsky.social, @kusterlab.bsky.social, @anamdv.bsky.social, @jsandow.bsky.social
The Brixen Proteomics Summer School speaker list has been finalised!. Lots of amazing science to be discussed! Big thanks to @eupaproteomics.bsky.social @msaid-de.bsky.social @thermofishersci.bsky.social @biognosys.bsky.social @ionopticks.bsky.social @evosep.bsky.social for support
March 7, 2025 at 10:52 AM
Shout out to the organisers @jesperolsenlab.bsky.social, (Tina Ludwig) @baybioms.bsky.social kathrynslilley.bsky.social, Caroline May and Britta Eggers
and the speakers @bonalditiziana.bsky.social, @coscialab.bsky.social, @kusterlab.bsky.social, @anamdv.bsky.social, @jsandow.bsky.social
and the speakers @bonalditiziana.bsky.social, @coscialab.bsky.social, @kusterlab.bsky.social, @anamdv.bsky.social, @jsandow.bsky.social
Reposted by Coscia Lab
Our selected speakers doe rhe different sessions are:
Georg Kustacher - bioinformatics
@coscialab.bsky.social single cell/spatial session
Manuel Mayr - clinical proteomics
Richard Seltema - structural
Freddie Theodolou - non-human proteomics
Jyoti Choudary - functional proteomics
Georg Kustacher - bioinformatics
@coscialab.bsky.social single cell/spatial session
Manuel Mayr - clinical proteomics
Richard Seltema - structural
Freddie Theodolou - non-human proteomics
Jyoti Choudary - functional proteomics
February 13, 2025 at 1:24 PM
Our selected speakers doe rhe different sessions are:
Georg Kustacher - bioinformatics
@coscialab.bsky.social single cell/spatial session
Manuel Mayr - clinical proteomics
Richard Seltema - structural
Freddie Theodolou - non-human proteomics
Jyoti Choudary - functional proteomics
Georg Kustacher - bioinformatics
@coscialab.bsky.social single cell/spatial session
Manuel Mayr - clinical proteomics
Richard Seltema - structural
Freddie Theodolou - non-human proteomics
Jyoti Choudary - functional proteomics
Reposted by Coscia Lab
"Innovations in Single Cell Omics" Berlin 5.12-13.
Keynote Speakers:
@shalinhnaik.bsky.social
Pulin Li, and me!
Invited Speakers:
@emmanuel-saliba.bsky.social
@mratz.bsky.social
Barbara Grünwald
Maria Colomé-Tatché
Mohammad Lotfollahi
@coscialab.bsky.social
Teresa Krieger
www.isco-conference.eu
Keynote Speakers:
@shalinhnaik.bsky.social
Pulin Li, and me!
Invited Speakers:
@emmanuel-saliba.bsky.social
@mratz.bsky.social
Barbara Grünwald
Maria Colomé-Tatché
Mohammad Lotfollahi
@coscialab.bsky.social
Teresa Krieger
www.isco-conference.eu
ISCO - ISCO
www.isco-conference.eu
February 27, 2025 at 9:40 PM
"Innovations in Single Cell Omics" Berlin 5.12-13.
Keynote Speakers:
@shalinhnaik.bsky.social
Pulin Li, and me!
Invited Speakers:
@emmanuel-saliba.bsky.social
@mratz.bsky.social
Barbara Grünwald
Maria Colomé-Tatché
Mohammad Lotfollahi
@coscialab.bsky.social
Teresa Krieger
www.isco-conference.eu
Keynote Speakers:
@shalinhnaik.bsky.social
Pulin Li, and me!
Invited Speakers:
@emmanuel-saliba.bsky.social
@mratz.bsky.social
Barbara Grünwald
Maria Colomé-Tatché
Mohammad Lotfollahi
@coscialab.bsky.social
Teresa Krieger
www.isco-conference.eu
Wonderful group dinner tonight, #proudPImoment ☺️🫶
February 26, 2025 at 10:10 PM
Wonderful group dinner tonight, #proudPImoment ☺️🫶
Next up at the @fogenomics.bsky.social proteomics stage, @ajbrenes.com talking about single-cell proteomics applied to neutrophils. Cool stuff!
January 30, 2025 at 4:38 PM
Next up at the @fogenomics.bsky.social proteomics stage, @ajbrenes.com talking about single-cell proteomics applied to neutrophils. Cool stuff!
Extremely happy that our Deep Visual Proteomics pipeline is one of the highlighted @naturemethods.bsky.social Spatial Proteomics approaches! 🥳 Congrats to the growing DVP team(s)! Making it broadly accessible & advancing it to the multiomics space is a key mission in our lab @mdc-berlin.bsky.social
I could not be more thrilled to announce the Nature Methods @naturemethods.bsky.social Method of the Year is Spatial Proteomics! Please see our editorial as a roadmap to the fantastic content in this special issue! www.nature.com/articles/s41...
Method of the Year 2024: spatial proteomics - Nature Methods
Approaches for profiling the spatial proteome in tissues are the basis of atlas-scale projects that are delivering on their promise for understanding biological complexity in health and disease.
www.nature.com
December 8, 2024 at 4:11 PM
Extremely happy that our Deep Visual Proteomics pipeline is one of the highlighted @naturemethods.bsky.social Spatial Proteomics approaches! 🥳 Congrats to the growing DVP team(s)! Making it broadly accessible & advancing it to the multiomics space is a key mission in our lab @mdc-berlin.bsky.social