Finally, I contend that my artistic capabilities 👨‍🎨 are also excellent having come up with the original concept art (below) which Gina used as a guide. Give us your opinions on who you think did it best 😅 !

Second annual Conway/ Coughlan lab pumpkin carving competition this morning with plenty of coffee and treats to keep us going! Skills getting better every year.

Can anyone spot the nucleosomes?

@coughlan-lab.bsky.social
@ucddublin.bsky.social
@ucd-sbbs.bsky.social

Our very own Evan Matthews, from @coughlan-lab.bsky.social, will be running the Dublin Marathon this month in aid of the Irish Cancer Society!

If you want to show Evan and the ICS your support you can donate through the link below!

eventmaster.ie/fundraising/...

@ucddublin.bsky.social

🏃💨

Really excited to share the line up for this years @arrefoundation.bsky.social research symposium. It was a pleasure to contribute to putting the program together this year.

Looking forward to seeing everyone in Boston in October!

More details can be found here: asxlconference.org

Great to enjoy the last of the Irish summer with a lab BBQ to celebrate paper acceptance 🎉 and individual grant/ travel/ poster prizes over the last few months! ☀️ 🍖 🍻

@coughlan-lab.bsky.social

Anyone looking to Europe for research & interested in chromatin biology then we have opportunities in UCD, Ireland. Welcoming & diverse group & we would love to add thanksgiving to our seasonal celebrations!

Postdoc: conwaychromatinlab.com/team

PhD (MSc not required): www.coughlan-lab.com/team

Happy international day of women and girls in science!

Shout out to the amazing women in our lab working every day to better understand ovarian cancer, leukemia and Bohring-Opitz syndrome! 👩‍🔬🧬

Celebrating a lot of lab milestones this year and the first Conway/Coughlan lab joint Christmas party 🎄🎅

@coughlan-lab.bsky.social

Although TFs are difficult to drug, several attempts have had success (i.e AR & Myc). Future efforts to specifically target TFs may involve advances in targeted protein degradation (oligoTRAFTACs). This could facilitate 'modular' approaches to tailor treatments to specific TFs.

Our understanding of which lineage-specific TFs drive cell fate has led to intriguing discoveries in functional genomics studies in the cancer field (thanks to large scale efforts like DepMap). These TFs represent some of the most specific and potent genetic dependencies in distinct cancers.

Starting with core regulatory circuit we review the importance of these networks in cell fate decisions and controlling regulatory elements like enhancers.

This is the first of (hopefully) many forays into transcription factor field for the lab! Brief 'bluesky-torial' (do we do that here 😬?) below!

Then, for our final webinar before Christmas, we will be joined by Luciano Di Croce for his webinar on 'Dissecting Dynamics of Chromatin Function in Cell Differentiation and Cancer' on December 12th. Registration here:
us06web.zoom.us/webinar/regi...

Our All-Ireland Chromatin Consortium Winter line up is fast approaching! We have two webinars in quick succession to spoil you with 🎄 ☃ .

We are delighted to welcome Emma Farley for her webinar 'Dependency Grammar of Developmental Enhancers' on Nov 22nd. Register: us06web.zoom.us/webinar/regi...