Sam Collie
@collieman13.bsky.social
PhD student at the University of Michigan
He/Him || Studying Cell Signaling in Neutrophils || I like Tea, Climbing, and Science
He/Him || Studying Cell Signaling in Neutrophils || I like Tea, Climbing, and Science
It’s fortunate that preprint servers are already well-established and robust. As an early career researcher, I still find the pull to publish as prestigiously as possible for my first paper. Recently I’ve started the painful process of disabusing myself of this notion.
September 9, 2025 at 1:37 PM
It’s fortunate that preprint servers are already well-established and robust. As an early career researcher, I still find the pull to publish as prestigiously as possible for my first paper. Recently I’ve started the painful process of disabusing myself of this notion.
With recent NIH news it seems much more plausible that the demise of Journals as the de facto method of sharing science is eminent.
September 9, 2025 at 1:37 PM
With recent NIH news it seems much more plausible that the demise of Journals as the de facto method of sharing science is eminent.
Fascinating study with absolutely mind-blowing good EM images. I’m curious about these trimmer and junction points that form in the HFs. How stable are these structures? Is there a unique lipid composition required for this?
Also, is the idea that this is limited to HF structures or canon MVBs too?
Also, is the idea that this is limited to HF structures or canon MVBs too?
May 20, 2025 at 5:32 AM
Fascinating study with absolutely mind-blowing good EM images. I’m curious about these trimmer and junction points that form in the HFs. How stable are these structures? Is there a unique lipid composition required for this?
Also, is the idea that this is limited to HF structures or canon MVBs too?
Also, is the idea that this is limited to HF structures or canon MVBs too?
once admirable? our government has always existed to promote the interests of american corporations abroad, at any cost
May 18, 2025 at 1:37 AM
once admirable? our government has always existed to promote the interests of american corporations abroad, at any cost
Congratulations Tim!
March 31, 2025 at 2:33 PM
Congratulations Tim!
This adds to another fascinating paper showing that membrane proteins like lamin B receptor travel not through the central channel at all, but around the side of the nuclear pore complex through a peripheral channel.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Nucleoplasmic signals promote directed transmembrane protein import simultaneously via multiple channels of nuclear pores - Nature Communications
The contribution of central and peripheral channels of nuclear pores to transport of transmembrane proteins is unclear. Here the authors show that most inner nuclear membrane proteins use only periphe...
www.nature.com
March 28, 2025 at 3:46 PM
This adds to another fascinating paper showing that membrane proteins like lamin B receptor travel not through the central channel at all, but around the side of the nuclear pore complex through a peripheral channel.
www.nature.com/articles/s41...
www.nature.com/articles/s41...