Clinical Epidemiology Basel
@clinepi-basel.bsky.social
Towards better clinical research with an impact on clinical care and global public health
The #ComBaCaL project in Lesotho shows that empowering community health workers to diagnose hypertension and diabetes isn't just feasible — it delivers high population coverage at moderate cost: www.thelancet.com/journals/lan...
Costs and coverage of community health worker-led hypertension and diabetes screening in rural Lesotho (ComBaCaL): cost–consequence analysis of a cohort study
CHWs, by use of a clinical decision support application run on an electronic tablet,
provided high hypertension and diabetes screening coverage at moderate costs. Our
findings support the integration ...
www.thelancet.com
November 3, 2025 at 9:10 AM
The #ComBaCaL project in Lesotho shows that empowering community health workers to diagnose hypertension and diabetes isn't just feasible — it delivers high population coverage at moderate cost: www.thelancet.com/journals/lan...
The study protocol for the process evaluation substudy of the #LIQPLAT trial, which evaluates the use of ctDNA in decision-making for advanced solid cancers, is now published in #BMJOpen.
🔗 Full article: lnkd.in/eFWBhtze
ℹ️ More information on the LIQPLAT trial: liqplat.com
🔗 Full article: lnkd.in/eFWBhtze
ℹ️ More information on the LIQPLAT trial: liqplat.com
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lnkd.in
October 30, 2025 at 4:06 PM
The study protocol for the process evaluation substudy of the #LIQPLAT trial, which evaluates the use of ctDNA in decision-making for advanced solid cancers, is now published in #BMJOpen.
🔗 Full article: lnkd.in/eFWBhtze
ℹ️ More information on the LIQPLAT trial: liqplat.com
🔗 Full article: lnkd.in/eFWBhtze
ℹ️ More information on the LIQPLAT trial: liqplat.com
Trials within Cohorts (#TwiCs) is an innovative study design that embeds randomized trials directly within ongoing cohort studies.
The Swiss HIV Cohort Study (#SHCS) — a well-established, nationwide cohort — has now implemented the TwiCs design for the first time in Switzerland.
The Swiss HIV Cohort Study (#SHCS) — a well-established, nationwide cohort — has now implemented the TwiCs design for the first time in Switzerland.
October 8, 2025 at 6:51 AM
Trials within Cohorts (#TwiCs) is an innovative study design that embeds randomized trials directly within ongoing cohort studies.
The Swiss HIV Cohort Study (#SHCS) — a well-established, nationwide cohort — has now implemented the TwiCs design for the first time in Switzerland.
The Swiss HIV Cohort Study (#SHCS) — a well-established, nationwide cohort — has now implemented the TwiCs design for the first time in Switzerland.
Reposted by Clinical Epidemiology Basel
Today at #PRC10: Analysis of 347 RCTs in Europe and Canada in 2016
Co-author @schwenkej.bsky.social found industry-sponsored trials were more often completed and available.
🔗 Read the study: ja.ma/41I2etz
@peerreviewcongress.bsky.social
Co-author @schwenkej.bsky.social found industry-sponsored trials were more often completed and available.
🔗 Read the study: ja.ma/41I2etz
@peerreviewcongress.bsky.social
September 6, 2025 at 1:01 AM
Today at #PRC10: Analysis of 347 RCTs in Europe and Canada in 2016
Co-author @schwenkej.bsky.social found industry-sponsored trials were more often completed and available.
🔗 Read the study: ja.ma/41I2etz
@peerreviewcongress.bsky.social
Co-author @schwenkej.bsky.social found industry-sponsored trials were more often completed and available.
🔗 Read the study: ja.ma/41I2etz
@peerreviewcongress.bsky.social
Reposted by Clinical Epidemiology Basel
Nonregistration, premature discontinuation due to poor recruitment, and nonpublication of #RCT results remain major challenges, especially for nonindustry trials
@schwenkej.bsky.social @clinepi-basel.bsky.social
@unibas.ch @mcmasteruniversity.bsky.social
#OpenScience #MetaResearch #PeerReview
@schwenkej.bsky.social @clinepi-basel.bsky.social
@unibas.ch @mcmasteruniversity.bsky.social
#OpenScience #MetaResearch #PeerReview
September 5, 2025 at 4:01 PM
Nonregistration, premature discontinuation due to poor recruitment, and nonpublication of #RCT results remain major challenges, especially for nonindustry trials
@schwenkej.bsky.social @clinepi-basel.bsky.social
@unibas.ch @mcmasteruniversity.bsky.social
#OpenScience #MetaResearch #PeerReview
@schwenkej.bsky.social @clinepi-basel.bsky.social
@unibas.ch @mcmasteruniversity.bsky.social
#OpenScience #MetaResearch #PeerReview
📝 New study: Mental health & substance use among adolescents in Lesotho🇱🇸
Older teens (15–17) most affected: girls → more mental health issues, boys → more substance use.
Yet only 17% accessed care.
Urgent need for youth-friendly services.
Read more:
onlinelibrary.wiley.com/doi/10.1111/...
Older teens (15–17) most affected: girls → more mental health issues, boys → more substance use.
Yet only 17% accessed care.
Urgent need for youth-friendly services.
Read more:
onlinelibrary.wiley.com/doi/10.1111/...
August 28, 2025 at 8:25 AM
📝 New study: Mental health & substance use among adolescents in Lesotho🇱🇸
Older teens (15–17) most affected: girls → more mental health issues, boys → more substance use.
Yet only 17% accessed care.
Urgent need for youth-friendly services.
Read more:
onlinelibrary.wiley.com/doi/10.1111/...
Older teens (15–17) most affected: girls → more mental health issues, boys → more substance use.
Yet only 17% accessed care.
Urgent need for youth-friendly services.
Read more:
onlinelibrary.wiley.com/doi/10.1111/...
🤰🤱 New data from Lesotho: Antiretroviral therapy during pregnancy & breastfeeding is preventing infants from HIV. But there’s still more to do. 🧵
July 30, 2025 at 12:13 PM
🤰🤱 New data from Lesotho: Antiretroviral therapy during pregnancy & breastfeeding is preventing infants from HIV. But there’s still more to do. 🧵
🚨New publication!
📝 Community-Based chronic Care Lesotho (ComBaCaL) cohort profile
a cohort of 14,700+ people in rural Lesotho, uncovering the intersection of chronic disease, poverty, & care access.
📝 Community-Based chronic Care Lesotho (ComBaCaL) cohort profile
a cohort of 14,700+ people in rural Lesotho, uncovering the intersection of chronic disease, poverty, & care access.
July 28, 2025 at 7:51 AM
🚨New publication!
📝 Community-Based chronic Care Lesotho (ComBaCaL) cohort profile
a cohort of 14,700+ people in rural Lesotho, uncovering the intersection of chronic disease, poverty, & care access.
📝 Community-Based chronic Care Lesotho (ComBaCaL) cohort profile
a cohort of 14,700+ people in rural Lesotho, uncovering the intersection of chronic disease, poverty, & care access.
💇🏾♀️ New publication from our team: Hair Salons as a promising space to provide HIV & Sexual and SRH services for young women in Lesotho
💭 The team is currently looking for funding to implement a pilot - ideas welcome!
Read more here: bmcpublichealth.biomedcentral.com/articles/10....
💭 The team is currently looking for funding to implement a pilot - ideas welcome!
Read more here: bmcpublichealth.biomedcentral.com/articles/10....
Hair salons as a promising space to provide HIV and sexual and reproductive health services for young women in Lesotho: a citizen scientist mixed-methods study - BMC Public Health
Introduction Adolescent girls and young women in southern Africa are disproportionately affected by HIV and sexual and reproductive health (SRH) challenges. There is a need for more accessible and de-...
bmcpublichealth.biomedcentral.com
July 8, 2025 at 7:11 PM
💇🏾♀️ New publication from our team: Hair Salons as a promising space to provide HIV & Sexual and SRH services for young women in Lesotho
💭 The team is currently looking for funding to implement a pilot - ideas welcome!
Read more here: bmcpublichealth.biomedcentral.com/articles/10....
💭 The team is currently looking for funding to implement a pilot - ideas welcome!
Read more here: bmcpublichealth.biomedcentral.com/articles/10....
🥁Now publication on the availability of trial protocols!
🔗Check out the link for the open access paper:
www.sciencedirect.com/science/arti...
@jclinepi.bsky.social @unibas.ch @dkf.unibas.ch @snsf.ch
🔗Check out the link for the open access paper:
www.sciencedirect.com/science/arti...
@jclinepi.bsky.social @unibas.ch @dkf.unibas.ch @snsf.ch
July 3, 2025 at 7:48 AM
🥁Now publication on the availability of trial protocols!
🔗Check out the link for the open access paper:
www.sciencedirect.com/science/arti...
@jclinepi.bsky.social @unibas.ch @dkf.unibas.ch @snsf.ch
🔗Check out the link for the open access paper:
www.sciencedirect.com/science/arti...
@jclinepi.bsky.social @unibas.ch @dkf.unibas.ch @snsf.ch
💡 New study on behavioral health for people with HIV in Lesotho 🇱🇸: Phone-based care has pros & cons, but trusted individuals are key for support & accountability. From Butha-Buthe and Mokhotlong. 🧑⚕️📞👥
Read more 👉
Read more 👉
June 23, 2025 at 7:24 AM
💡 New study on behavioral health for people with HIV in Lesotho 🇱🇸: Phone-based care has pros & cons, but trusted individuals are key for support & accountability. From Butha-Buthe and Mokhotlong. 🧑⚕️📞👥
Read more 👉
Read more 👉
🌞 ClinEpi Summer Event 2025
We just wrapped up an unforgettable summer event featuring fun quizzes & games and ending off with an exciting cooking challenge 🍴 A huge thank you to everyone who joined, competed and organised this event, we are already looking forward to the next one!
We just wrapped up an unforgettable summer event featuring fun quizzes & games and ending off with an exciting cooking challenge 🍴 A huge thank you to everyone who joined, competed and organised this event, we are already looking forward to the next one!
June 20, 2025 at 7:48 AM
🌞 ClinEpi Summer Event 2025
We just wrapped up an unforgettable summer event featuring fun quizzes & games and ending off with an exciting cooking challenge 🍴 A huge thank you to everyone who joined, competed and organised this event, we are already looking forward to the next one!
We just wrapped up an unforgettable summer event featuring fun quizzes & games and ending off with an exciting cooking challenge 🍴 A huge thank you to everyone who joined, competed and organised this event, we are already looking forward to the next one!
Our secondary analysis of 533 peer reviewer reports found that reminders about reporting guidelines increased reviewer attention—but the effect diminished due to article rejections and limited implementation by authors.
🔗Full publication@jclinepi.bsky.social : www.sciencedirect.com/science/arti...
🔗Full publication@jclinepi.bsky.social : www.sciencedirect.com/science/arti...
June 6, 2025 at 7:54 AM
Our secondary analysis of 533 peer reviewer reports found that reminders about reporting guidelines increased reviewer attention—but the effect diminished due to article rejections and limited implementation by authors.
🔗Full publication@jclinepi.bsky.social : www.sciencedirect.com/science/arti...
🔗Full publication@jclinepi.bsky.social : www.sciencedirect.com/science/arti...
New publication from our team: Drivers of chronic depressive and harmful alcohol use symptoms among adults living with HIV in Lesotho: pathways for integrated interventions
🔗: www.sciencedirect.com/science/arti...
🔗: www.sciencedirect.com/science/arti...
Drivers of chronic depressive and harmful alcohol use symptoms among adults living with HIV in Lesotho: pathways for integrated interventions
Mental health problems are prevalent among people with HIV (PWH) in Southern Africa. However, mental health problems are substantially under-diagnosed…
www.sciencedirect.com
May 20, 2025 at 11:25 AM
New publication from our team: Drivers of chronic depressive and harmful alcohol use symptoms among adults living with HIV in Lesotho: pathways for integrated interventions
🔗: www.sciencedirect.com/science/arti...
🔗: www.sciencedirect.com/science/arti...
🚀 Join us for Geneva Digital Health Day 2025! 🌍💻
Felix Gerber will give a short presentation on digital innovation in low- and middle-income countries.
📅 Date: Thursday, 22 May 2025
🕘 Time: 09:00–17:30 CET
📍 Location: Campus Biotech, Geneva, Switzerland
🔗 Register here: gdhub.org/25gdhd/
Felix Gerber will give a short presentation on digital innovation in low- and middle-income countries.
📅 Date: Thursday, 22 May 2025
🕘 Time: 09:00–17:30 CET
📍 Location: Campus Biotech, Geneva, Switzerland
🔗 Register here: gdhub.org/25gdhd/
May 19, 2025 at 5:27 PM
🚀 Join us for Geneva Digital Health Day 2025! 🌍💻
Felix Gerber will give a short presentation on digital innovation in low- and middle-income countries.
📅 Date: Thursday, 22 May 2025
🕘 Time: 09:00–17:30 CET
📍 Location: Campus Biotech, Geneva, Switzerland
🔗 Register here: gdhub.org/25gdhd/
Felix Gerber will give a short presentation on digital innovation in low- and middle-income countries.
📅 Date: Thursday, 22 May 2025
🕘 Time: 09:00–17:30 CET
📍 Location: Campus Biotech, Geneva, Switzerland
🔗 Register here: gdhub.org/25gdhd/
🚀 New study out
Clinical trials often face overoptimistic budgets and funding shortfalls, leading to costly trial discontinuations. We reviewed Swiss budgeting tools and found untested, inconsistent methods without prespecified cost ranges.
Article: trialsjournal.biomedcentral.com/articles/10....
Clinical trials often face overoptimistic budgets and funding shortfalls, leading to costly trial discontinuations. We reviewed Swiss budgeting tools and found untested, inconsistent methods without prespecified cost ranges.
Article: trialsjournal.biomedcentral.com/articles/10....
Clinical trial budgeting approaches in Switzerland—a meta-research study - Trials
Background Conducting clinical trials is resource demanding. Mirroring challenges experienced elsewhere, clinical trials conducted in Switzerland often face overoptimistic budget estimations and insuf...
trialsjournal.biomedcentral.com
May 16, 2025 at 12:16 PM
🚀 New study out
Clinical trials often face overoptimistic budgets and funding shortfalls, leading to costly trial discontinuations. We reviewed Swiss budgeting tools and found untested, inconsistent methods without prespecified cost ranges.
Article: trialsjournal.biomedcentral.com/articles/10....
Clinical trials often face overoptimistic budgets and funding shortfalls, leading to costly trial discontinuations. We reviewed Swiss budgeting tools and found untested, inconsistent methods without prespecified cost ranges.
Article: trialsjournal.biomedcentral.com/articles/10....
With over 96% of global trial data on this topic included, this #IPDMA, published in @lancetrespirmed.bsky.social and initiated by #EU-RESPONSE, provides the most comprehensive analysis for JAK inhibitors for adults hospitalized due to #COVID19.
Full article: www.thelancet.com/journals/lan...
Full article: www.thelancet.com/journals/lan...
Effects of Janus kinase inhibitors in adults admitted to hospital due to COVID-19: a systematic review and individual participant data meta-analysis of randomised clinical trials
This IPDMA of RCTs in adults admitted to hospital due to COVID-19 found that JAK inhibitors
reduced mortality across all levels of respiratory support, independent of dexamethasone
or tocilizumab, and...
www.thelancet.com
May 15, 2025 at 6:15 AM
With over 96% of global trial data on this topic included, this #IPDMA, published in @lancetrespirmed.bsky.social and initiated by #EU-RESPONSE, provides the most comprehensive analysis for JAK inhibitors for adults hospitalized due to #COVID19.
Full article: www.thelancet.com/journals/lan...
Full article: www.thelancet.com/journals/lan...
Reposted by Clinical Epidemiology Basel
📰 New Article: Effects of Janus kinase inhibitors in adults admitted to hospital with #COVID19: a systematic review and IPD meta-analysis of randomised clinical trials
Findings suggested that JAK inhibitors reduced mortality across all levels of respiratory support
🔗 tinyurl.com/2hprv99v
Findings suggested that JAK inhibitors reduced mortality across all levels of respiratory support
🔗 tinyurl.com/2hprv99v
May 14, 2025 at 1:56 PM
📰 New Article: Effects of Janus kinase inhibitors in adults admitted to hospital with #COVID19: a systematic review and IPD meta-analysis of randomised clinical trials
Findings suggested that JAK inhibitors reduced mortality across all levels of respiratory support
🔗 tinyurl.com/2hprv99v
Findings suggested that JAK inhibitors reduced mortality across all levels of respiratory support
🔗 tinyurl.com/2hprv99v
Last week in Maseru, leaders from Lesotho’s Ministry of Health and local organisations gathered for the 13th National Health Research Symposium. 🇱🇸📊
The event highlighted the importance of locally led, evidence-based research — now more critical than ever! 🩺📚
The event highlighted the importance of locally led, evidence-based research — now more critical than ever! 🩺📚
April 15, 2025 at 11:03 AM
Last week in Maseru, leaders from Lesotho’s Ministry of Health and local organisations gathered for the 13th National Health Research Symposium. 🇱🇸📊
The event highlighted the importance of locally led, evidence-based research — now more critical than ever! 🩺📚
The event highlighted the importance of locally led, evidence-based research — now more critical than ever! 🩺📚
🌍 EVENT: Challenges & Opportunities in Global Mental Health 🧠
Join us at the @swisstph.ch on June 3, 2025 (2:00 PM – 5:00 PM) for a discussion with experts from @columbiauniversity.bsky.social , @uzh-ch.bsky.social, @swisstph.ch , and University Hospital Basel!
🔗 RSVP: nat.johnson@unibas.ch
Join us at the @swisstph.ch on June 3, 2025 (2:00 PM – 5:00 PM) for a discussion with experts from @columbiauniversity.bsky.social , @uzh-ch.bsky.social, @swisstph.ch , and University Hospital Basel!
🔗 RSVP: nat.johnson@unibas.ch
March 14, 2025 at 10:37 AM
🌍 EVENT: Challenges & Opportunities in Global Mental Health 🧠
Join us at the @swisstph.ch on June 3, 2025 (2:00 PM – 5:00 PM) for a discussion with experts from @columbiauniversity.bsky.social , @uzh-ch.bsky.social, @swisstph.ch , and University Hospital Basel!
🔗 RSVP: nat.johnson@unibas.ch
Join us at the @swisstph.ch on June 3, 2025 (2:00 PM – 5:00 PM) for a discussion with experts from @columbiauniversity.bsky.social , @uzh-ch.bsky.social, @swisstph.ch , and University Hospital Basel!
🔗 RSVP: nat.johnson@unibas.ch
🚨Save the date!
March 26th, Prof. @stephensenn.bsky.social will travel to #Basel and give a presentation on methodology and statistics in #RCTs. He will share his insights on why we randomize trials, the value of balance, whether trials should be representative, and much more.
March 26th, Prof. @stephensenn.bsky.social will travel to #Basel and give a presentation on methodology and statistics in #RCTs. He will share his insights on why we randomize trials, the value of balance, whether trials should be representative, and much more.
March 3, 2025 at 5:47 PM
🚨Save the date!
March 26th, Prof. @stephensenn.bsky.social will travel to #Basel and give a presentation on methodology and statistics in #RCTs. He will share his insights on why we randomize trials, the value of balance, whether trials should be representative, and much more.
March 26th, Prof. @stephensenn.bsky.social will travel to #Basel and give a presentation on methodology and statistics in #RCTs. He will share his insights on why we randomize trials, the value of balance, whether trials should be representative, and much more.
📢 New publication: Prevalence and factors associated with dementia in Lesotho
We found a probable dementia prevalence of 5% in Lesotho, aligning with regional estimates for Africa. 🧠
alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
We found a probable dementia prevalence of 5% in Lesotho, aligning with regional estimates for Africa. 🧠
alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
Prevalence and factors associated with dementia in Lesotho: A cross‐sectional, population‐based study
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alz-journals.onlinelibrary.wiley.com
February 28, 2025 at 9:28 AM
📢 New publication: Prevalence and factors associated with dementia in Lesotho
We found a probable dementia prevalence of 5% in Lesotho, aligning with regional estimates for Africa. 🧠
alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
We found a probable dementia prevalence of 5% in Lesotho, aligning with regional estimates for Africa. 🧠
alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
🧪 Insights from the VICONEL Cohort on HIV Care in Lesotho 🧵(1/54)
Check out the full cohort profile here: bmjopen.bmj.com/content/15/2...
Check out the full cohort profile here: bmjopen.bmj.com/content/15/2...
Cohort profile: the Viral load Cohort North-East Lesotho (VICONEL) from 2016 to 2023 – cohort description, test volumes, predictors of viraemia and the road ahead
Purpose The prospective Viral load Cohort North-East Lesotho (VICONEL) aims to support clinical management and generate scientific evidence to inform HIV care. Specifically, VICONEL allows for the mon...
bmjopen.bmj.com
February 14, 2025 at 10:52 AM
🧪 Insights from the VICONEL Cohort on HIV Care in Lesotho 🧵(1/54)
Check out the full cohort profile here: bmjopen.bmj.com/content/15/2...
Check out the full cohort profile here: bmjopen.bmj.com/content/15/2...
📊 New study on the effectiveness of behavioral interventions for substance use & HIV. Our pilot study, 'Khanya', shows how brief, skills-based interventions can also improve employment rates!
🧵 (1/4)
🧵 (1/4)
February 11, 2025 at 8:08 AM
📊 New study on the effectiveness of behavioral interventions for substance use & HIV. Our pilot study, 'Khanya', shows how brief, skills-based interventions can also improve employment rates!
🧵 (1/4)
🧵 (1/4)