Brian Clark
@clark-lab-retina.bsky.social
Assist. Prof - WashU - Ophthalmology. Dev biologist studying regulation of retinal cell fate specification - Epigenetics and non-coding RNAs
Reposted by Brian Clark
Happy to share the definitive version of our last paper about the role of TET enzymes and DNA demethylation in retinal development @clark-lab-retina.bsky.social journals.plos.org/plosbiology/...
Active DNA demethylation upstream of rod-photoreceptor fate determination is required for retinal development
TET enzymes remove DNA methylation markers, but the role of this process in retinal development is not clear. This study shows that these enzymes are required for photoreceptor cells to initiate the g...
journals.plos.org
September 4, 2025 at 6:09 PM
Happy to share the definitive version of our last paper about the role of TET enzymes and DNA demethylation in retinal development @clark-lab-retina.bsky.social journals.plos.org/plosbiology/...
Our work on the TET enzymes in retinal development is out. We identified that rod fate is inhibited when DNA demethylation is prevented by removal of the TET enzymes. Interestingly, photoreceptor numbers are normal. We utilized WGBS and bACE-seq to profile the precise localization of 5mC and 5hmC,…
TET enzymes remove #DNAmethylation markers; @ismaelhdeznunez.bsky.social @clark-lab-retina.bsky.social &co show that these enzymes are required for #photoreceptor cells to initiate the genetic program to become rods instead of cones, & for maturation of the #retina @plosbiology.org 🧪 plos.io/3UaVBfl
August 6, 2025 at 3:19 AM
Our work on the TET enzymes in retinal development is out. We identified that rod fate is inhibited when DNA demethylation is prevented by removal of the TET enzymes. Interestingly, photoreceptor numbers are normal. We utilized WGBS and bACE-seq to profile the precise localization of 5mC and 5hmC,…
Reposted by Brian Clark
Well, the Biology and Development of the Eye (BDE) study section has been postponed (previously scheduled for Thurs/Fri).
I’m very disappointed on behalf of the applicants and reviewers, who all want this meeting to happen. I’m also grateful to the NIH staff who work so hard to make science happen.
I’m very disappointed on behalf of the applicants and reviewers, who all want this meeting to happen. I’m also grateful to the NIH staff who work so hard to make science happen.
February 26, 2025 at 4:53 PM
Well, the Biology and Development of the Eye (BDE) study section has been postponed (previously scheduled for Thurs/Fri).
I’m very disappointed on behalf of the applicants and reviewers, who all want this meeting to happen. I’m also grateful to the NIH staff who work so hard to make science happen.
I’m very disappointed on behalf of the applicants and reviewers, who all want this meeting to happen. I’m also grateful to the NIH staff who work so hard to make science happen.
First post on this platform is to announce that our preprint is posted to bioRxiv:
bioRxiv 2025.02.03.636318; doi: doi.org/10.1101/2025...
bioRxiv 2025.02.03.636318; doi: doi.org/10.1101/2025...
doi.org
February 4, 2025 at 9:15 PM
First post on this platform is to announce that our preprint is posted to bioRxiv:
bioRxiv 2025.02.03.636318; doi: doi.org/10.1101/2025...
bioRxiv 2025.02.03.636318; doi: doi.org/10.1101/2025...