Clara
@claragathmann.bsky.social
Chemist apprentice Chembiologist at TSRI San Diego - Spends the day chasing the perfect bioactive molecule
Reposted by Clara
Excited to share a new preprint from the lab. We show that PTMs like phosphorylation & glycosylation dynamically reshape proteome-wide ligandability in cells, including proteins like KRAS. Great collaboration with the Huang Lab, @forlilab.bsky.social and BMS. www.biorxiv.org/content/10.1...
Post-Translational Modifications Remodel Proteome-Wide Ligandability
Post-translational modifications (PTMs) vastly expand the diversity of human proteome, dynamically reshaping protein activity, interactions, and localization in response to environmental, pharmacologi...
www.biorxiv.org
August 3, 2025 at 2:36 PM
Excited to share a new preprint from the lab. We show that PTMs like phosphorylation & glycosylation dynamically reshape proteome-wide ligandability in cells, including proteins like KRAS. Great collaboration with the Huang Lab, @forlilab.bsky.social and BMS. www.biorxiv.org/content/10.1...
Reposted by Clara
Happy to share a new preprint from our group in collaboration with AbbVie led by graduate student @inesforrest.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Proteome-Wide Discovery of Degradable Proteins Using Bifunctional Molecules
Targeted protein degradation (TPD) is an emergent therapeutic strategy with the potential to circumvent challenges associated with targets unamenable to conventional pharmacological inhibition. Among ...
www.biorxiv.org
March 23, 2025 at 7:09 AM
Happy to share a new preprint from our group in collaboration with AbbVie led by graduate student @inesforrest.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Clara
Breaking news: Thousands of researchers and their supporters, including recently fired federal workers, have gathered across the U.S. in response to layoffs and funding cuts ordered by the Trump administration. scim.ag/41zlPv4
Thousands gather across U.S. in Stand Up for Science events
Scientists rally across the country in response to layoffs and funding cuts ordered by the Trump administration
scim.ag
March 7, 2025 at 6:27 PM
Breaking news: Thousands of researchers and their supporters, including recently fired federal workers, have gathered across the U.S. in response to layoffs and funding cuts ordered by the Trump administration. scim.ag/41zlPv4
Reposted by Clara
Reposted by Clara
STAND UP FOR SCIENCE! Join us and thousands nationwide on Friday, March 7th at noon at the UC San Diego Geisel Library / Silent Tree
February 28, 2025 at 2:08 PM
STAND UP FOR SCIENCE! Join us and thousands nationwide on Friday, March 7th at noon at the UC San Diego Geisel Library / Silent Tree
Reposted by Clara
Great seeing our recent antiviral PROTAC paper chosen by Nature Comms Editors as one of the 50 best papers in Microbiology and Infectious Diseases!
www.nature.com/collections/...
www.nature.com/collections/...
Microbiology and infectious diseases
This page highlights recent articles on all aspects of bacteriology, mycology, parasitology and virology, covering the biology of pathogens, host-pathogen ...
www.nature.com
March 5, 2025 at 4:16 PM
Great seeing our recent antiviral PROTAC paper chosen by Nature Comms Editors as one of the 50 best papers in Microbiology and Infectious Diseases!
www.nature.com/collections/...
www.nature.com/collections/...
Reposted by Clara
Antiviral drug development:
Small molecules inducing degradation of host protein cyclophilin A show #antiviral activity against HIV-1 & HCV
@towerslab.bsky.social @lsnewton.bsky.social @claragathmann.bsky.social
@jollylab.bsky.social @alessiociulli.bsky.social
www.nature.com/articles/s41...
Small molecules inducing degradation of host protein cyclophilin A show #antiviral activity against HIV-1 & HCV
@towerslab.bsky.social @lsnewton.bsky.social @claragathmann.bsky.social
@jollylab.bsky.social @alessiociulli.bsky.social
www.nature.com/articles/s41...
Macrocycle-based PROTACs selectively degrade cyclophilin A and inhibit HIV-1 and HCV - Nature Communications
Targeted protein degradation has so far been rarely applied as an antiviral strategy. Here, the authors report that macrocycle-based PROTACs targeting host protein cyclophilin A, exploited during vira...
www.nature.com
February 28, 2025 at 3:01 PM
Antiviral drug development:
Small molecules inducing degradation of host protein cyclophilin A show #antiviral activity against HIV-1 & HCV
@towerslab.bsky.social @lsnewton.bsky.social @claragathmann.bsky.social
@jollylab.bsky.social @alessiociulli.bsky.social
www.nature.com/articles/s41...
Small molecules inducing degradation of host protein cyclophilin A show #antiviral activity against HIV-1 & HCV
@towerslab.bsky.social @lsnewton.bsky.social @claragathmann.bsky.social
@jollylab.bsky.social @alessiociulli.bsky.social
www.nature.com/articles/s41...
Reposted by Clara
February 26, 2025 at 1:58 AM