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Reposted by clamryn

Chise

@sailorrooscout.bsky.social

In preclinical models, treatment repaired brain pathology, restored cognitive function, and normalized Alzheimer’s biomarkers (in HUMAN models as well).
• case.edu/news/new-stu...

The study has been published in Cell. YES, it is PEER-REVIEWED.
• www.cell.com/cell-reports...

🧪🧵⬇️

Highlights
•Severity of Alzheimer's disease (AD) correlates with
NAD+ homeostasis dysregulation
•Preserving brain NAD+ homeostasis prevents AD in mice
• Restoring brain NAD+ homeostasis reverses advanced
AD in mice
• Multiomics across human and mouse AD brain identifies nodes for human AD reversal
Summary
Alzheimer's has long been considered irreversible, but new research challenges that assumption. Scientists discovered that severe drops in the brain's energy supply help drive the disease-and restoring that balance can reverse damage, even in advanced cases.
In mouse models, treatment repaired brain pathology, restored cognitive function, and normalized Alzheimer's biomarkers. The results offer fresh hope that recovery may be possible.

Abstract
Alzheimer's disease (AD) is traditionally considered irreversible. Here, however, we provide proof of principle for therapeutic reversibility of advanced AD. In advanced disease amyloid-driven 5xFAD mice, treatment with P7C3-A20, which restores nicotinamide adenine dinucleotide (NAD+) homeostasis, reverses tau phosphorylation, blood-brain barrier deterioration, oxidative stress, DNA damage, and neuroinflammation and enhances hippocampal neurogenesis and synaptic plasticity, resulting in full cognitive recovery and reduction of plasma levels of the clinical AD biomarker p-tau217.
P7C3-A20 also reverses advanced disease in tau-driven
PS19 mice and protects human brain microvascular endothelial cells from oxidative stress. In humans and mice, pathology severity correlates with disruption of brain NAD+ homeostasis, and the brains of nondemented people with Alzheimer's neuropathology exhibit gene expression patterns suggestive of preserved NAD+ homeostasis. Forty-six proteins aberrantly expressed in advanced 5xFAD mouse brain and normalized by P7C3-A20 show similar alterations in human AD brain, revealing targets with potential for optimizing translation to patient care.

Graphical Abstract (CREDIT: Cell Reports Medicine)

December 28, 2025 at 5:03 PM

Reposted by clamryn

Ahhhhh

@nerdjpg.com

it is so amazing that he is just taking a sledgehammer to our capitalist psyops and government restructuring all over the planet. he is so fucking stupid

Whey Standard @wheystandard.bsky.social · Feb 27

Elon Musk: people are falsely claiming DOGE can cancel federal contracts.

Also Elon Musk:

February 27, 2025 at 8:02 PM

Reposted by clamryn

Ink Witch

@ink-witch.bsky.social

Couldnt sleep, have a little test flame Vivian Bridget

February 27, 2025 at 7:24 AM

Reposted by clamryn

Appleseed’s Strongest Soldier

@wiresandflesh.bsky.social

The Yakuza/Like A Dragon games are fundamentally about the separation between crimes that are rad (beating up rivals, storming hideouts, street racing) and crimes that are lame (stealing money from the poor, selling out your friends, being a loan shark) and that's why it's a good series

February 27, 2025 at 5:09 AM

Reposted by clamryn

Silmerion

@throwsare.cheap

These are vtubers.

Fightful Wrestling @fightful.com · Feb 10

WWE Files Trademarks On 'Drako Knox,' 'Haze Jameson,' 'Trill London,' And More

WWE Files Trademarks On 'Drako Knox,' 'Haze Jameson,' 'Trill London,' And More | Fightful News

WWE files multiple trademarks on ring names.

www.fightful.com

February 10, 2025 at 4:58 PM

Reposted by clamryn

Martin Rosner

@hotpaper.bsky.social

panel 1
man thinking: Am I still a good person if helping others also benefits me?

panel 2
disembodied voice from far away: Hey, man

panel 3
picture of the entire universe: It's me, the universe

panel 4
universe: Be kind, I don't care why

January 7, 2025 at 9:17 PM

clamryn

@clamryn.bsky.social

Trans JC Denton: my gender is augmented.

January 6, 2025 at 1:13 AM

Reposted by clamryn

LoreleiGirlfriend

@loreleigirlfriend.bsky.social

mario getting his dick sucked:

wahoo! i'm-a getting my dick-a sucked! yahoo!

December 15, 2024 at 10:13 PM

clamryn

@clamryn.bsky.social

Posting once again about my dog's surgery #gofundme

gofund.me/cb2619d6

Please help

Donate to Support Pandi's Life-Saving Surgery, organized by Debi O.

Hi, my name is Debi and I'm raising funds for our family dog Pandi. She has progressive la… Debi O. needs your support for Support Pandi's Life-Saving Surgery

gofund.me

November 9, 2024 at 5:26 PM

clamryn

@clamryn.bsky.social

Posting again about my dog's surgery #gofundme

gofund.me/cb2619d6

November 8, 2024 at 11:27 PM

Reposted by clamryn

clamryn

@clamryn.bsky.social

Posting about the gofundme for our dog's surgery again.

gofund.me/6f57c784

Please share the link around and contribute if you can

Donate to Support Pandi's Life-Saving Surgery, organized by Debi O.

Hi, my name is Debi and I'm raising funds for our family dog Pandi. She has progressive la… Debi O. needs your support for Support Pandi's Life-Saving Surgery

gofund.me

November 7, 2024 at 1:36 PM

clamryn

@clamryn.bsky.social

Posting about the gofundme for our dog's surgery again.

gofund.me/6f57c784

Please share the link around and contribute if you can

Donate to Support Pandi's Life-Saving Surgery, organized by Debi O.

Hi, my name is Debi and I'm raising funds for our family dog Pandi. She has progressive la… Debi O. needs your support for Support Pandi's Life-Saving Surgery

gofund.me

November 7, 2024 at 1:36 PM

Reposted by clamryn

clamryn

@clamryn.bsky.social

I made a gofundme to help pay for my dog's surgery, gofund.me/cb2619d6
Please share it around if you can.

Donate to Support Pandi's Life-Saving Surgery, organized by Debi O.

Hi, my name is Debi and I'm raising funds for our family dog Pandi. She has progressive la… Debi O. needs your support for Support Pandi's Life-Saving Surgery

gofund.me

November 6, 2024 at 7:22 PM

clamryn

@clamryn.bsky.social

I made a gofundme to help pay for my dog's surgery, gofund.me/cb2619d6
Please share it around if you can.

Donate to Support Pandi's Life-Saving Surgery, organized by Debi O.

Hi, my name is Debi and I'm raising funds for our family dog Pandi. She has progressive la… Debi O. needs your support for Support Pandi's Life-Saving Surgery

gofund.me

November 6, 2024 at 7:22 PM

Reposted by clamryn

TTRPG Class Identifier

@bskyttrpg.bsky.social

Congratulations, you are now a catfolk.

November 5, 2024 at 9:19 PM

clamryn

@clamryn.bsky.social

@bskyttrpg.bsky.social chooseancestry catfolk

November 5, 2024 at 9:19 PM

clamryn

@clamryn.bsky.social

@bskyttrpg.bsky.social stats

November 5, 2024 at 9:17 PM

clamryn

@clamryn.bsky.social

@bskyttrpg.bsky.social listcommands

November 5, 2024 at 9:16 PM

clamryn

@clamryn.bsky.social

I am so starved for contact and joy that everything feels unreal, and yet my pain — my disease binds me with the rope of sickening sensation to my horrid flesh prison. It is as though my entire being has become one singular phantom pain.

September 24, 2024 at 5:26 PM

clamryn

@clamryn.bsky.social

I have a lot more reach on cohost than I do on other platforms. Since cohost is shutting down soon, this might be my last chance to make a significant dent in our debt.

If you have a cohost account, would you mind please rechosting this post for me?

cohost.org/Camryn/post/...