Congrats! That's awesome news.

Thank you!

Thank you!

Thank you!

Thank you!

Thank you Sunny!

Thank you to all of my amazing co-authors in the @cadwelllab.bsky.social and Koralov lab!

In addition, we also see these inflammatory responses after cage change in mock mice. This highlights that we should be aware of the side effects common mouse husbandry practices can introduce into experiments.

This initially represses immune responses and allows virus expansion. Once stress is resolved, CD8 T cells in the gut become activated and induce inflammatory responses in the epithelium leading to virus clearance. Therefore, manipulating the environment we can shorten the duration of an infection.

We noticed variability in the length of infection for one of our enteric model viruses, murine Astrovirus, and discovered that the virus was cleared because of the stress following cage changes. The new environment leads to production of stress hormones such a glucocorticoids.